Marcadores subclínicos de aterosclerosis y factores de riesgo cardiovascular en artritis temprana

Autores/as

  • Carla Andrea Gobbi Universidad Nacional de Córdoba
  • Patricia Asbert Universidad Nacional de Córdoba
  • Paula Beatriz Alba Universidad Nacional de Córdoba
  • Jorge Resk Centro de Estudios Ecográficos Cuvertino
  • Gladys Dotto Hospital Córdoba
  • Marcela Demarchi Hospital Córdoba
  • Eduardo Cuvertino Centro de Estudios Ecográficos Cuvertino
  • Gustavo Alberto Pepe Universidad Nacional de Córdoba
  • Daniel Antonio Salica Universidad Nacional de Córdoba
  • Eduardo Horacio Albiero Universidad Nacional de Córdoba
  • Felipe Martínez Universidad Nacional de Córdoba

DOI:

https://doi.org/10.31053/1853.0605.v76.n3.21610

Palabras clave:

artritis, aterosclerosis, ultrasonido, ecografía, artritis reumatoide

Resumen

La mortalidad por Enfermedad cardiovascular (ECV) temprana está incrementada en enfermedades inflamatorias. Los marcadores ecográficos de aterosclerosis subclínica (AS) están estrechamente relacionados con ECV.

Objetivo: Evaluar marcadores de AS ecográficos y Factores de Riesgo Cardiovascular (FRCV) en Artritis temprana (AT) y correlacionarlo con la actividad de la enfermedad.

Material y Métodos: Estudio transversal de casos y controles en pacientes con AT, definida por 3 articulaciones inflamadas con menos de 1 año de evolución,  realizado desde 2011 a 2013, apareados con controles sanos, por sexo, edad y FRCV. Se registraron datos demográficos, FRCV, rigidez de pared (cIMT) en Arteria Carótida Común (ACC) y en Bulbo Carotídeo (BC) y presencia de placas ateroscleróticas por ecografía, perfil lipídico, Proteína C Reactiva, eritrosedimentación, anticuerpos anti péptido citrulinado, Factor reumatoide, anticuerpos antinucleares. La actividad de AT se midió por Disease Activity Score (DAS) 28.  Estadística: Se usaron test U de Mann-Whitney, Kruskal Wallis y chi-cuadrado, p <0,05 fue significativo.

Resultados: Se incluyeron 25 mujeres, 5 hombres con edad promedio 40 años (18-61) y  30 controles. El DAS 28 promedio fue 4,8 ±1.8. Pacientes y controles tuvieron similares valores  cIMT ACC (0, 57 ±0.10 mm vs  0,58 ± 0,15 mm, respectivamente)  y  cIMT CB (0,67 ±0,18mm vs 0,62 ±0,15 mm), no hubo placas carotídeas y el perfil lipídico fue similar en ambos grupos, PNS. El cIMT CCA y CB no tuvieron relación con DAS 28, serología, ni FRCV, P: NS.

Conclusiones: La aterosclerosis subclínica se produciría después del primer año de enfermedad en artritis temprana.  

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Biografía del autor/a

Carla Andrea Gobbi, Universidad Nacional de Córdoba

Profesora Doctora en Medicina y Cirugía. UNC

Profesora Titular de la Cátedra de Clínica Médica I Hospital Córdoba. Facultad de Ciencias Médicas. UNC

Médica Reumatóloga del Sanatorio Allende.

Patricia Asbert, Universidad Nacional de Córdoba

Médica Especialista en Clínica Médica

Médica Especialista en Reumatología

Médica de Guardia del Hospital Córdoba

 

Paula Beatriz Alba, Universidad Nacional de Córdoba

Profesora Doctora en Medicina y Cirugía

Profesora Asociada a la Cátedra de Semiología, UHMI N°3, Hospital Córdoba, FCM, UNC

Jefa de la Unidad de Reumatología del Hospital Córdoba

Jorge Resk, Centro de Estudios Ecográficos Cuvertino

Médico Especialista en Cardiología

Médico del Centro de Estudios Ecográficos Cuvertino

Gladys Dotto, Hospital Córdoba

Jefa del Laboratorio del Hospital Córdoba

Especialista en Bioquímica Clínica

Marcela Demarchi, Hospital Córdoba

Jefa de la Sección Inmunología del Servicio de Laboratorio del Hospital Córdoba. 

Bioquímica especialista en Inmunología

Eduardo Cuvertino, Centro de Estudios Ecográficos Cuvertino

Médico Especialista en Diagnóstico por Imágenes

Director Médico del Centro de Estudios Ecográficos Cuvertino

Gustavo Alberto Pepe, Universidad Nacional de Córdoba

Profesor Adjunto de la Cátedra de Clínca Médica I de la Facultad de Ciencias Médicas de la Universidad Nacional de Córdoba. 

Director del centro de Formación en Clínica Médica San Juan Bautista Catamarca. 

Daniel Antonio Salica, Universidad Nacional de Córdoba

Profesor Doctor en Medicina y Cirugía

Jefe de la Cátedra de Clínica Médica II, UHMI N°2, Hospital San Roque, FCM, UNC

Eduardo Horacio Albiero, Universidad Nacional de Córdoba

Especialista en Reumatología

Director del posgrado de la Carrera de Especialista en Reumatología, Secretaría de Graduados de Ciencias de la Salud, FCM, UNC

Felipe Martínez, Universidad Nacional de Córdoba

Prof Dr. en Medicina y Cirugía

Ex Jefe de la Cátedra de Clínica Médica I, UHMI N°3, Hospital Córdoba, FCM, UNC

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Publicado

2019-08-29

Cómo citar

1.
Gobbi CA, Asbert P, Alba PB, Resk J, Dotto G, Demarchi M, Cuvertino E, Pepe GA, Salica DA, Albiero EH, Martínez F. Marcadores subclínicos de aterosclerosis y factores de riesgo cardiovascular en artritis temprana. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 29 de agosto de 2019 [citado 14 de abril de 2024];76(3):174-9. Disponible en: https://revistas.unc.edu.ar/index.php/med/article/view/21610

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