Marcadores subclínicos de aterosclerose e fatores de risco cardiovascular na artrite precoce
DOI:
https://doi.org/10.31053/1853.0605.v76.n3.21610Palavras-chave:
artrite, aterosclerose, ultrassonografia, artrite reumatóideResumo
A mortalidade por doença cardiovascular precoce (DCV) está aumentada em doenças inflamatórias. Marcadores de ultra-som de aterosclerose subclínica (AS) estão intimamente relacionados com DCV.
Objetivo: Avaliar os marcadores de AS ultrassonográfica e Fatores de Risco Cardiovascular (FRCV) na artrite precoce (AT) e correlacioná-la com a atividade da doença.
Material e Métodos: Estudo transversal de casos e controles em pacientes com AT, definido por 3 articulações inflamadas com menos de 1 ano de evolução, realizadas de 2011 a 2013, pareadas com controles saudáveis, por sexo, idade e FRCV. Dados demográficos, FRCV, rigidez de parede (CIMT) foram registrados na artéria carótida comum (ACC) e no bulbo carotídeo (BC) e presença de placas ateroscleróticas por ultrassom, perfil lipídico, proteína C-reativa, eritrosedimentação, anticorpos anti-peptídeo citrulinado, fator anticorpos antinucleares reumatóides. A atividade da AT foi medida pelo Escore de Atividade da Doença (DAS) 28. Estatísticas: Teste U de Mann-Whitney, Kruskal Wallis e qui-quadrado foram usados, p <0,05 foi significante.
Resultados: 25 mulheres, 5 homens com idade média de 40 anos (18-61) e 30 controles foram incluídos. O DAS médio foi de 4,8 ± 1,8. Os pacientes e controles tiveram valores semelhantes de ACIM da cIMT (0,57 ± 0,10 mm vs 0,58 ± 0,15 mm, respectivamente) e CBIMc (0,67 ± 0,18 mm vs 0,62 ± 0,15 mm), não havia placas carotídeas e o perfil lipídico foi semelhante nos dois grupos, PNS. A CIMT CCA e CB não tiveram relação com DAS 28, sorologia ou FRCV, P: NS.
Conclusões: A aterosclerose subclínica ocorreria após o primeiro ano da doença na artrite precoce.
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