Obesidad, adipoquinas y lupus eritematoso sistémico

Autores/as

  • Tomas Urrego Universidad de Antioquia Facultad de Medicina, Medellín, Colombia
  • Gloria M Vazquez Universidad de Antioquia, Medellín, Colombia
  • José A Gómez-Puerta Universidad de Antioquia. Medellin, Colombia

DOI:

https://doi.org/10.31053/1853.0605.v73.n1.14296

Palabras clave:

Obesidad, Lupus Eritematoso Sistémico

Resumen

La obesidad es una estado pro-inflamatorio crónico en el cual participan una serie de procesos celulares incluyendo cambios fenotípicos de macrófagos, alteraciones en el  equilibrio de citoquinas, y un aumento en la expresión de moléculas reguladoras del sistema inmune derivadas de adipocitos y macrófagos residentes de tejido adiposo – también denominadas adipoquinas. Tales adipoquinas como la leptina, la adiponectina, y la resistina, son, entre otras, algunas de las más estudiadas hasta el momento. De igual manera, estas adipoquinas pueden tener un posible rol en la fisiopatología del lupus eritematoso sistémico, al promover diferentes procesos pro-inflamatorios; por lo tanto, representan también posibles dianas terapéuticas para el tratamiento de esta enfermedad.

 

 

Abstract

Obesity is a pro-inflammatory state characterized by phenotypic changes in macrophages, alterations on cytokines balance, and increasing expression of regulatory molecules of the immune system derived from adipocytes and adipose tissue macrophages – also known as adipokines. Currently, leptin, adiponectin and resistin are, among others, one of the most known adipokines. These adipokines might play a possible role in systemic lupus erythematosus pathogenesis, by promoting different pro-inflammatory conditions. Adipokines represent a possible treatment target in patients with lupus. 

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Gloria M Vazquez, Universidad de Antioquia, Medellín, Colombia

Grupo de Inmunología Celular e Inmunogenética

José A Gómez-Puerta, Universidad de Antioquia. Medellin, Colombia

Grupo de Inmunología Celular e Inmunogenética

Citas

Cannon B, Nedergaard J. Brown Adipose Tissue: Function and Physiological Significance. Physiol Rev. 2004;84(1):277-359.

DiSilvestro D, Petrosino J, Aldoori A, Melgar-Bermudez E, Wells A, Ziouzenkova O. Enzymatic intracrine regulation of white adipose tissue. HormMolBiolClinInvestig. 2014;19(1):39-55.

Stanford K, Middelbeek R, Goodyear L. Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations. Diabetes. 2015;64(7):2361-68.

Weisberg S, McCann D, Desai M, Rosenbaum M, Leibel R, Ferrante A. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796-808.

Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol. 2014;222(3):R113-27.

Hotamisligil G, Shargill N, Spiegelman B. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87-91.

Hyvönen M, Spalding K. Maintenance of white adipose tissue in man. IntJ Biochem Cell Biol. 2014;56:123-32.

Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-Reactive Protein Levels in Overweight and Obese Adults. JAMA. 1999;282(22):2131-35.

Neels J, Olefsky JM. Inflamed fat: what starts the fire?. J Clin Invest. 2006;116(1):33-35.

Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5(12):953-64.

Gordon S, Martinez FO. Alternative Activation of Macrophages: Mechanism and Functions. Immunity. 2010;32(5):593-604.

Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007; 117(1):175-84.

Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372(6505):425-32.

Green E, Maffei M, Braden V, Proenca R, DeSilva U, Zhang Y et al. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res. 1995;5(1):5-12.

Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404(6778):661-71.

Münzberg H, Morrison CD. Structure, production and signaling of leptin. Metabolism. 2015;64(1):13-23.

Guo K, McMinn JE, Ludwig T, Yu YH, Yang G, Chen L et al. Disruption of Peripheral Leptin Signaling in Mice Results in Hyperleptinemia without Associated Metabolic Abnormalities. Endocrinology. 2007;148(8):3987-97.

Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. ProcNatlAcadSci USA. 1996;93(16):8374-78.

Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000;68(4):437-46.

Aleffi S, Petrai I, Bertolani C, Parola M, Colombatto S, Novo E et al. Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology. 2005;42(6):1339-48.

Scherer P, Williams S, Fogliano M, Baldini G, Lodish H. A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes. J Biol Chem. 1995;270(45):26746-49.

Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T et al. Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin. J Biol Chem. 2003;278(11):9073-85.

Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423(6941):762-69.

Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y et al. Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages. Circulation. 2001;103(8):1057-63.

Koerner A, Kratzsch J, Kiess W. Adipocytokines: leptin—the classical, resistin—the controversical, adiponectin—the promising, and more to come. Best Prac Res ClinEndocrinolMetab. 2005;19(4):525-46.

Gilcampos M, Cañete RR, Gil A .Adiponectin, the missing link in insulin resistance and obesity. ClinNutr. 2004;23(5):963-74.

Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H et al. Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF- B Signaling Through a cAMP-Dependent Pathway. Circulation. 2000;102(11):1296-301.

Takahashi N, Tetsuka T, Uranishi H, Okamoto T. Inhibition of the NF-κB transcriptional activity by protein kinase A. Eur J Biochem. 2002;269(18):4559-65.

Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM et al. The hormone resistin links obesity to diabetes. Nature. 2001;409(6818):307-12.

Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L. Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones. Science. 2004;304(5674):1154-58.

Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, Plumpton C et al. Resistin is expressed in human macrophages and directly regulated by PPARγ activators. BiochemBiophys Res Commun. 2003;300(2):472-6.

Lee S, Lee HC, Kwon YW, Lee SE, Cho Y, Kim J et al. Adenylyl Cyclase-Associated Protein 1 Is a Receptor for Human Resistin and Mediates Inflammatory Actions of Human Monocytes. Cell Metab. 2014;19(3):484-97.

Lu SC, Shieh WY, Chen CY, Hsu SC, Chen HL. Lipopolysaccharide increases resistin gene expression in vivo and in vitro. FEBS Lett. 2002;530(1-3):158-62.

Cho Y, Lee SE, Lee HC, Hur J, Lee S, Youn SW et al. AdipokineResistin Is a Key Player to Modulate Monocytes, Endothelial Cells, and Smooth Muscle Cells, Leading to Progression of Atherosclerosis in Rabbit Carotid Artery. J Am CollCardiol. 2011;57(1):99-109.

Mirabelli G, Cannarile F, Bruni C, Vagelli R, De Luca R, Carli L. One year in review 2015: systemic lupus erythematosus. ClinExpRheumatol. 2015;33(3):414-25.

Kurokawa J, Nagano H, Ohara O, Kubota N, Kadowaki T, Arai S et al. Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue. ProcNatlAcadSci USA. 2011;108(29):12072-77.

Versini M, Jeandel PY, Rosenthal E, Shoenfeld Y. Obesity in autoimmune diseases: Not a passive bystander. Autoimmun Rev. 2014;13(9):981-1000.

Manzel A, Muller DN, Hafler DA, Kleinewietfeld M. Role of “western diet” in inflammatory autoimmune diseases. CurrAllergyAsthma Rep. 2014;14(1):404.

Brown K, DeCoffe D, Molcan E, Gibson DL. Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease. Nutrients. 2012;4(11): 1552–3

Yang C-Y, Leung PSC, Adamopoulos IE, Gershwin ME. The implication of vitamin D and autoimmunity: a comprehensive review. Clin Rev Allergy Immunol. 2013;45(2):217–26.

Mina R, Klein-Gitelman MS, Nelson S, Eberhard BA, Higgins G, Singer NG, et al. Effects of obesity on health-related quality of life in juvenile-onset systemic lupus erythematosus. Lupus 2015;24(2):191-7.

Rizk A, Gheita TA, Nassef S, Abdallah A. The impact of obesity in systemic lupus erythematosus on disease parameters, quality of life, functional capacity and the risk of atherosclerosis.Int J Rheum Dis. 2012;15(3):261-7.

Procaccini C, Pucino V, Mantzoros CS, Matarese G. Leptin in autoimmune diseases. Metabolism. 2015;64(1):92-104.

Xu W, Zhang M, Zhang Y, Liu S, Pan H, Ye D. Association between leptin and systemic lupus erythematosus.Rheumatol Int. 2014;34(4):559-63.

Barbosa V, Rêgo J, da Silva N. Possible role of adipokines in systemic lupus erythematosus and rheumatoid arthritis. Rev Bras Reumatol. 2012;52(2):271-87.

Vadacca M, Margiotta D, Rigon A, Cacciapaglia F, Coppolino G, Amoroso A et al. Adipokines and Systemic Lupus Erythematosus: Relationship with Metabolic Syndrome and Cardiovascular Disease Risk Factors. JRheumatol. 2009;36(2):295-97.

Wisłowska M, Rok M, Stępień K, Kuklo-Kowalska A. Serum leptin in systemic lupus erythematosus.Rheumatol Int. 2008;28(5):467-73.

Rovin BH, Song H, Hebert LA, Nadasdy T, Nadasdy G, Birmingham DJ et al. Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus. Kidney Int. 2005; 68(4):1825-33.

Hutcheson J. Adipokines influence the inflammatory balance in autoimmunity. Cytokine. 2015; 75(2):272-79.

Song H, Chan J, Rovin BH. Induction of chemokine expression by adiponectin in vitro is isoform dependent. Transl Res. 2009;154(1):18-26.

Krysiak R, Handzlik-Orlik G, Okopien B. The role of adipokines in connective tissue diseases. Eur JNutr. 2012;51(5):513-28.

Almehed K, d'Elia HF, Bokarewa M, Carlsten H. Role of resistin as a marker of inflammation in systemic lupus erythematosus. Arthritis Res Ther. 2008;10(1):R15.

Baker JF, Morales M, Qatanani M, Cucchiara A, Nackos E, Lazar MA et al. Resistin Levels in Lupus and Associations with Disease-specific Measures, Insulin Resistance, and Coronary Calcification. J Rheumatol. 2011;38(11):2369-75.

Hutcheson J, Ye Y, Han J, Arriens C, Saxena R, Li Q et al. Resistin as a potential marker of renal disease in lupus nephritis. ClinExpImmunol. 2015;179(3):435-43.

Descargas

Publicado

2016-02-27

Cómo citar

1.
Urrego T, Vazquez GM, Gómez-Puerta JA. Obesidad, adipoquinas y lupus eritematoso sistémico. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 27 de febrero de 2016 [citado 28 de marzo de 2024];73(1). Disponible en: https://revistas.unc.edu.ar/index.php/med/article/view/14296

Número

Sección

Originales Breves