OBESIDAD, ADIPOQUINAS Y LUPUS ERITEMATOSO SISTÉMICO

Tomas Urrego, Gloria M Vazquez, José A Gómez-Puerta

Resumen


La obesidad es una estado pro-inflamatorio crónico en el cual participan una serie de procesos celulares incluyendo cambios fenotípicos de macrófagos, alteraciones en el  equilibrio de citoquinas, y un aumento en la expresión de moléculas reguladoras del sistema inmune derivadas de adipocitos y macrófagos residentes de tejido adiposo – también denominadas adipoquinas. Tales adipoquinas como la leptina, la adiponectina, y la resistina, son, entre otras, algunas de las más estudiadas hasta el momento. De igual manera, estas adipoquinas pueden tener un posible rol en la fisiopatología del lupus eritematoso sistémico, al promover diferentes procesos pro-inflamatorios; por lo tanto, representan también posibles dianas terapéuticas para el tratamiento de esta enfermedad.

 

 

Abstract

Obesity is a pro-inflammatory state characterized by phenotypic changes in macrophages, alterations on cytokines balance, and increasing expression of regulatory molecules of the immune system derived from adipocytes and adipose tissue macrophages – also known as adipokines. Currently, leptin, adiponectin and resistin are, among others, one of the most known adipokines. These adipokines might play a possible role in systemic lupus erythematosus pathogenesis, by promoting different pro-inflammatory conditions. Adipokines represent a possible treatment target in patients with lupus. 


Palabras clave


Obesidad; Lupus Eritematoso Sistémico

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Referencias


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