Characterization of the HIV-1 subtypes present in Córdoba (Argentina) from nearly the beginning of the infection, using the POL and ENV Genes.

Raul Enrique Gonzalez Ittig, María A. Lucca, Luciana Caeiro, Nidia M. Modesti

Resumen


Objective: Identify the HIV-1 subtypes circulating in Córdoba, Argentina, in the period 1986-2001. Methods: Sequences of the pol and env genes from strains of Córdoba were compared with those of the HIV-1 M-group (several subtypes and circulating recombinant forms). Then, to determine if Cordoba’s subtypes had a single or multiple geographic origins, sequences were subdivided into pure-subtype data sets (avoiding the effects of recombination) and compared with sequences of diverse geographic origin. Results: Eighteen strains were subtype B, seven B/F1, one C and one F1. The B/F1 were: two CRF12_B/F1 and five unique recombinant forms (URF_B/F1). Córdoba’s subtype B would have multiple geographic origins, while subtypes F1 and C would have been introduced from Brazil or from Buenos Aires. Conclusions: The HIV-1 infection in Córdoba was complex since its very beginning and reveals its close contact, through tourism and commercial activities, with Buenos Aires and Brazil.


Palabras clave


HIV-1 infection; Córdoba, Argentina; HIV-1 subtypes; phylogenetic analyses; inter subtype recombinant strains

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Referencias


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Copyright (c) 2017 Raul Enrique Gonzalez Ittig

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Este obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.

Revista de la Facultad de Ciencias Médicas.
Pabellón Perú - Ciudad Universitaria
Facultad de Ciencias Médicas. Universidad Nacional de Córdoba
Argentina
ISSN impreso: 0014-6722 | ISSN en linea: 1853-0605

revistafcm@fcm.unc.edu.ar