Characterization of the HIV-1 subtypes present in Córdoba (Argentina) from nearly the beginning of the infection, using the POL and ENV Genes.

Raul Enrique Gonzalez Ittig


Objective: Identify the HIV-1 subtypes circulating in Córdoba, Argentina, in the period 1986-2001. Methods: Sequences of the pol and env genes from strains of Córdoba were compared with those of the HIV-1 M-group (several subtypes and circulating recombinant forms). Then, to determine if Cordoba’s subtypes had a single or multiple geographic origins, sequences were subdivided into pure-subtype data sets (avoiding the effects of recombination) and compared with sequences of diverse geographic origin. Results: Eighteen strains were subtype B, seven B/F1, one C and one F1. The B/F1 were: two CRF12_B/F1 and five unique recombinant forms (URF_B/F1). Córdoba’s subtype B would have multiple geographic origins, while subtypes F1 and C would have been introduced from Brazil or from Buenos Aires. Conclusions: The HIV-1 infection in Córdoba was complex since its very beginning and reveals its close contact, through tourism and commercial activities, with Buenos Aires and Brazil.

Palabras clave

HIV-1 infection; Córdoba, Argentina; HIV-1 subtypes; phylogenetic analyses; inter subtype recombinant strains

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Copyright (c) 2017 Raul Enrique Gonzalez Ittig

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Revista de la Facultad de Ciencias Médicas.
Pabellón Perú - Ciudad Universitaria
Facultad de Ciencias Médicas. Universidad Nacional de Córdoba
ISSN impreso: 1853-0605 | ISSN en linea: 0014-6722