Gastrointestinals stromal tumors: conceptual evolution
DOI:
https://doi.org/10.31053/1853.0605.v61.n1.26873Keywords:
tumor estromal gastrointestinal, leiomioblastorna, tumor autonómico gastrointestinal, células intersticiales de Cajal, fibras eskenoides, c-kit (CDII 7), CD34Abstract
Gastrointestinal strornal tumors (GISTs) constitute the largest category of primary noncpithelial neoplasms of the stomach ancl small bowel. They represent about 1-2% from all neoplasrns of the digestive tract. They occur most commonly in the stomach and small bowel, but small series of comparable tumors havc also been reported in all the other parts of the tubular gastrointestinal tract, inclucling esophagus. colon, rectum and amis. They can also involve omcntum, mesentery, uterus, retroperitoneum. mesocolon and soft tissucs. Originally recognized ¡u 1960 by Martin ct. al. as a clist.inctive type of stromal neoplasm of the bowel, they were subsequently reported by Stout. vlio introduced the term leiomyoblastorna. Because of difficulties ¡u accurately predicting the biologic behavior of these tuniors, the terrn "smooth muscle tumor of uncertain nialignant potential" (SMT- !JMP) has heen introduced for borderline tumors. In 1983. Mazur and Clark comed the terrn gastrointestinal stronial tumor and suggested that these neoplasias might arise from (he inyenteric nervous system. Sorne studies have reported evidence of neuronal cell clifferentiation ¡o a proportion of GISTs and the terrn 'gastrointestinal autonomic nerve tumor (GANT) has been introduced. Kindblorn et al are providing cogeni arguments to suggcst that GISTs show difíerentiation toward ¡nterstitiat Cajal celis (pacemaker celis of the gastrointestinal tracl). lnmnunohistochemically the GISTs often reveal lnmunoreactivity for vimentin. CD34 and CD! 17. Tlie airn of this paper is to perforrim and analysis of the historie evolution ami conceptual of the GISTs
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References
Rosal j: Stromal tumors. Ackerman 's Surgical Pathology. Moshy. St. Louis, 1996, p.€14.5-641.
Moral Moral G. Gil Piedra E Velasco Osés A y col.: Tumores estromales del tubo digestivo. Valor pronóstico del índice mitótico. Rey Esp Enferm Dig; 1998,90(5): 335-339
Miettinen M. Sarlomo-Rikala M. Lasota J: Gastrointestinal stromal tumours. [Review] 127 refsl. Annales Chirurgiae et Gynaecologiae; 1998,87(4): 278-281
Martin JE Bazin P Feroldi ,J, Cabanne F: Tumeurs rnyoides intra-murales des 1 estomac. Considcrations niicroscopiques a propos de 6 caS. AnnAnatPathol (París): 1960,13:25-33
Stout AP Bizarre smooth muscle tumours of the stomach. Cancer; 1962.15:400-409
Enzinger F.M., Lattcs. R. and Tortoloni. H. Histological Trping of Soft Tissue Tumours. International i-listological Classification of Tumours N 3. Geneva. 1969, World Health Organization
Morson BC. Dawson IMP: Gastrointestinal Pathology. Edited by Blackwell scie.ntific puhlications, Oxford, London, Edinburgh, Melbourne. 1974, p 368 -371. 2a. Ed. S.
Hendrickson R, Kempson RL: Smooth muscle tumours. In: Whitehead R. ed. Gastrointestinal and üesophageal Pathology. ¡st ed. Edinburgh:Churchill Livingstone. 1989. 619 -628
Chan JKC.: Mesenchymal Tumors of the Gastrointestinal Tract : A Paradise for Acronisms (STUMR GIST, GANT aral Now GIPACT), Implication of c-kit in Genesis, and yet Another of the Many Emerging Roles of the lnterstitial Celi of Cajal in the Pathogenesis of Gastrointestinal 1)iseases?. Advances ¡u Anatomic Pathology; 1999, 6(1): 19-40
Mazur MT, Clark HB: Gastric stromal tumors reappraisal of histogenesis. AmJSurg Pathol: 1983. 7: 507-519
Walker P. Dvorak AM: Gastrointestinal autonomic nerve (OAN) tumor. Ultrastructural evidence for a newly recognized entity. Arch Pathol Lab Med: 1986, 110: 309- 316
Herrera GA, Ccrezzo L, Janes JE. Sack J, et al: Gastrointestinal autonomic nerve tumors. "Plexosarcomas" Arch Pa thai LahMed: 1989.113:846-853
Kindhlom LO, Meis-Kindblom JM. Remotti HE, Aldenborg F: Gastrointestinal pacemaker: GJPACT: gastrointestinal stromal tumors show phenotypic characteristies of the interstitial celis of Cajal. Am J Pathol; 1998.152:1259-1269
Cajal S: Sur les ganglions et plexus nerveux de 1 intestin. Compt Renci Soc Biol. París; 1893, 45:217-223
ThunebergL: Intersiltial cells of Cajal: intestinal pacemaker cells?. Advances in Anatomy, Embriology and Celi Biology. Edited by F Beck. W Flild, J van Limborgh,R. Ortmann, JE Pauly, TH Sehiebler. Berlin. Heidelberg, New York. 1982.p 1-130. Springer Verlag.
ThomscnTL, Robinson TL. Lee JCF, et al: Interstitial celis of Cajal generate a rhvthrnic pacemaker current. Nature Med: 1998,4:848-851
MietUnem M. Furiong M. SarlomoRikala M y col: Gastrointestinal stromal tumors intramural leiomyomas and lciomyosarconias in the rectum and anus. A c1inicopathohlc, inmunohistochcmical. and molecular genetie study of 144 cases. Am 3 Surg Pathol; 2001, 25(9): 1121- 1133
Lavin P Hadju SI, Feote FW: Gastric and extragastrie leiomyoblastomas. Clinicopathologic study of 44 cases. Cancer: 1972.29:305 -3 11
Miettincn M. Lasota J: Gastrointestinal stromal tumors-definitlon. clinical, histological, immunohistochemical. and molecular genetic features and differential diagnosis. Virchows Arch; 2001, 438:1-12
Ortega Medina L. Saiz-Pardo Sanz, M: Tumores del estroma gastrointestinal: Cambio conceptual de los tumores estromales gastrointestinales (GISTs) y criterios de malignidad. Oncolog (Barc); 2004, 27(4): 1-7
Flctcher CD, Berman JJ. Corlcss C, Gorstein E Sobin LFI y col: Diagnosis of gastrointestinal stromal tumors: A consensus approach. HumPathol: 2002, 33:459-465
Sircar K. Hewlet BR, Huizinga JD, Chorneyko y col: lnterslitial cclls of Cala-]- as precursors of gastrointestinal stromal tumors. Am J Surg Pathol; 1999, 23 (4): 377 - 389
Erlandson RA, Klimstra DS, Wooddruff JM: Subclassification of gastrointestinal stromal tumors based mi evaluation by electron microscopy and inmunohistochemistry Ultrastr Pathol: 1996, 20: 373-393
Hirota S. Isozaki K. Moriyama Y et al: Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science: 1998, 279: 577-580
Farrugia G, Kim CH, Grant CS, Zinsmeister AR: Leiomyosarcoma of the stomach. Determinants of long-term survival. Mayo Clin Proc: 1992,67: 533-536
Persson S, Kindblom LG, Angervali L. Tiscli LE: Metastasizinggastric epithelioid leioinyosarcomas (leionwoblastomas) in young individuals with long-term survival. Cancer; 1992.70:721-732
Fuller CE, Williams GT: Gastrointestinal manifestations of type 1 neurofibromatosis (von Recklinghausen 's disease). Histopathology: 1991, 19: 1-11
Carney JA, Sep SG, Go VI- Gordon 11: 'l'he triad of gastric leiomyosarcorna, functioning extra-adrenal paragariglioma and pulmonary chondrorna. NEng1JMed; 1977,296: 1517-1518
Miettinem M. Virolainen M, SarlomoRikala M: Gastrointestinal stromal tuniorsvalue of CD34 antigen in their identification and separation from true leiomyomas and schwannomas. Am J SurgPathol: 1995.19: 207-216
Clary BM. DeMatteo RP Lewis JJ y col: Gastrointestinal stromal tumors and leiornyosarcoma of the abdomen and retroperitoneum: a clinical comparison. Am Surg Oncol: 2001, 8(4): 290-299
Pauwels 11 Debiec-Rychter M. Stul M y col.: Chariging phenotype of gastrointestinal stromal tumours under Imatinib rnesylatc treatrnent: a potential cliagnostic pitfall. I-listopathologv; 2005,47:41-47
Miettinem M. El-Rifai W. H L Sobin L. Lasota J: Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Ilum Pathol; 2002,33:478-483
Emory TS, Sohin L, Lukes L. Lee DII, O'Leary TJ: Prognosis of gastrointestinal smooth-rnuscle (stromal) tumors. Depenclence on anatomic site. Am J Surg Pathol; 1999, 23(1): 82-87
Evans HL: Smooth muscle neoplasm of the gastrointestinal tract: a study of 56 cases followcd for a minimum of ten years. Cancer: 1985, 56: 2242-2250
Amin MB, Ma CK, Linden MD y col: Pronostic value of proiiferating ceil nuclear antigen index in gastric stromal tumors: correlation with mitotic count and clinical outcome. Am J Clin Pathol: 1993, 100: 428- 432
Tworek JA, Appelman HD, Singleton TP Greenson JK: Stromal tumors of the jcjunum and ileum. Mod Pathol; 1997, 10: 200-209
El-Rifa¡ W. Sarlomo-Rikala M, Andcrsson LC y col. DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance. Cáncer Res; 2000, 60: 3899- 3903
Kim NG, Kim JJ, Ahn JY. Seong CM y col: Putative chromosomal deletions on 9R 9Q and 22Q occur preferentially in malignant gastrointestinal stromal tumors. mt j Cancer: 2000, 85: 633-638
Gunther T, Schrieider-Stock R, Hackel C y col: Telomerase activity and expression of hTRT and hTR in gastrointestinal stromal tumors in comparison with extragastrointestinal sarcomas. Clin Cancer Res; 2000, 6: 1811- 1818
Pauls K. Merkelbach-Bruse S. Thai D y col: PDGFR á - and c-kit-mutated gastrointestinal stromal turnours (GISTs) are characterized by distinctive histological and inmunohistochemical features. Histopahoiogy: 2005,46: 166-175.
Yantiss R, Sl)iro 1, Compton C y col: Gastrointestinal stromal tumor versus intraabdominal fibromatosis of the bowel wall. Am J Surg Pathol: 2000,24(7): 947-957
Huizinga JD. Thuneberg L. Kluppel y col.: W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature: 1995,373: 347-349
Miettinen M, Sarlomo-Rikala M. Lasota J: Gastrointestinal Stromal Tumors: recent advanees in understanding of their biology. HumPathol; 1999,30: 1213-1220
Saul SH, Rast MI. Brooks JJ: The inmunohistochemistry of gastrointestinal stromal tumors. Evidence supportingorigin from smooth muscle. Am J Surg Pathol: 1987,11:464-473
Weiss RA, Mackay B: Maiignant smooth muscle tumors of the gastrointestinal tract: an ultrastructural study of 20 cases. Ultrastruct Pathol: 1981. 2: 231-240
Miettinen M. Sohin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologie, inmunohistochemical, and molecular genelic study of 1765 cases with long-term followup. Am J Surg Pathol; 2005, 29: 52-68.
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