Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2

Autores/as

  • Emanuel Bottino Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba
  • Andrés Alberto Ponce Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba https://orcid.org/0000-0002-3322-9456

DOI:

https://doi.org/10.31053/1853.0605.v79.n1.30642

Palabras clave:

coronavirus, covid-19, inmunidad innata

Resumen

Introducción: La infección emergente producida por el nuevo coronavirus SARS-CoV-2, se ha constituido en un verdadero desafío para la comunidad científica. Actualmente, es escaso el conocimiento acerca de la patogenia de COVID-19 y en el último tiempo, se ha propuesto la participación de la respuesta inmunitaria propia del huésped, en la progresión de la enfermedad. La inmunidad innata pulmonar se constituye como la primera barrera ante diferentes noxas, que puedan provocar lesión tisular, con la consiguiente alteración de la función respiratoria. Sin embargo, una pérdida en la regulación de estos mecanismos inflamatorios puede provocar una disrupción en la homeostasis del tejido afectado. Objetivo: Evaluar el papel de la respuesta inmune innata pulmonar en la patogenia de COVID-19. Materiales y métodos: Se realizó una revisión sistemática de estudios publicados en buscadores científicos: PubMed, Google Scholar, Science Direct. Se utilizaron las siguientes palabras claves: “COVID-19”; “Acute Respiratory Distress Syndrome”; “SARS-CoV-2”; “Innate pulmonary immunity”; “innate immune response”. Resultados: Se encontró una alteración global de la respuesta inmune innata pulmonar en la infección por SARS-CoV-2, que tendría relevancia en la patogenia de COVID-19. Conclusión: La afectación global de la respuesta inmune innata y por consiguiente de la homeostasis tisular pulmonar, en la infección por SARS-CoV-2, requiere el diseño de nuevas estrategias terapéuticas destinadas a la modulación de los mecanismos pro inflamatorios alterados en COVID-19.

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Biografía del autor/a

Emanuel Bottino, Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba

Médico; Profesional adscripto en la Cátedra de Fisiología Humana de la Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Profesional colaborador del equipo de investigación del Dr. Andrés A. Ponce en el estudio de los macrófagos alveolares y el microambiente pulmonar

Andrés Alberto Ponce, Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba

Médico cirujano; Doctor en Medicina y cirugía, con más de 20 años de experiencia en investigación básica, actualmente su equipo de trabajo se dedica al estudio de la inflamación pulmonar y los macrófagos alveolares; Profesor asociado de la Cátedra de Fisiología Humana de la Facultad de Ciencias Médicas, Universidad Nacional de Córdoba; Profesor Titular por concurso en la Cátedra de Fisiología Humana de la facultad de Ciencias Médicas, Universidad Nacional de la Rioja.

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2022-03-07

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1.
Bottino E, Ponce AA. Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 7 de marzo de 2022 [citado 29 de marzo de 2024];79(1):33-42. Disponible en: https://revistas.unc.edu.ar/index.php/med/article/view/30642

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