Hipertensión arterial en pacientes con diabetes mellitus tipo 2 revisión

Autores/as

  • Mario Bendersky Universidad Nacional de Córdoba. Instituto Modelo de Cardiología Córdoba.
  • Ramiro Sánchez Universidad Favaloro.

DOI:

https://doi.org/10.31053/1853.0605.v70.n2.20243

Palabras clave:

hipertensión arterial, diabetes mellitus, riesgo cardiovascular, terapéutica no farmacológica y farmacológica

Resumen

La Hipertensión Arterial (HTA) y la Diabetes mellitus tipo 2 (DM2) se asocian frecuentemente, más del 65% de los diabéticos sufren algun tipo de HTA.
En Argentina la prevalencia de HTA es de alrededor del 30% de la población adulta y la prevalencia de DM2 alrededor del 5%.

Se describen la definición, distintas formas clínicas, el estudio del hipertenso, y la estratificación del riesgo cardiovascular, claramente se observa que, para distintos estadíos de HTA, la coexistencia de DM2 ó Sindrome Metabólico, eleva en forma notable el riesgo de eventos. Entre los factores de riesgo tradicionales, las condiciones socio-económicas deben recibir atención especial en Latinoamérica. Del mismo modo se debe hacer énfasis en el bajo nivel de educación, a causa del alto porcentaje de población nativa con bajas oportunidades de obtener una educación adecuada.

El tratamiento de la HTA en el diabético es una de las medidas mas efectivas para reducir el riesgo.Se analizan las metas tensionales en diabéticos, las medidas no farmacológicas que han demostrado eficacia preventiva, y las caracteristicas de los distintos grupos farmacológicos, así como de las asociaciones de drogas antihipertensivas, que muy frecuentemente se deben usar en estos pacientes. Ademas, se efectúan recomendaciones de selección de fármacos para pacientes con situaciones especiales.

Descargas

Los datos de descarga aún no están disponibles.

Referencias

1. Latin American consensus on hypertension in patients with diabetes type 2 and metabolic syndrome. López-Jaramillo P, Sánchez RA, Diaz M, Cobos L, Bryce A, Parra Carrillo JZ, Lizcano F, Lanas F, Sinay I, Sierra ID, Peñaherrera E, Bendersky M, Schmid H, Botero R, Urina M, Lara J, Foss MC, Márquez G, Harrap S, Ramírez AJ, Zanchetti A; on behalf of the Latin America Expert Group. J Hypertens. 2013 Feb;31(2):223-238.

2. World Health Organization, International Society of Hypertension Writing Group. World Health Organization-International Society of Hypertension statement on management of hypertension. J Hypertens 2003;21:1983-1992.

3. Prevention of Cardiovascular Disease. Guidelines for assessment and management of Cardiovascular Risk. World Health Organization, 2007.

4. Lewington S, Clarke F, Dizilbach N, Peto R, Collins R. Prospective Studies Collection. Age specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903-1.

5. Mancia G, de Backer G, Dominiczak A, et al: 2007 Guidelines for the Management of Arterial Hypertension The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007, 25: 1105–1187.

6. Mancia G, Laurent S, Agabiti-Rosei A et al. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertens 2009, 27: 2121 – 2158

7. OPS, Salud de las Américas 2007-2008-2009.

8. OMS: Prevención de las enfermedades crónicas, una inversión vital. 2004.

9. OPS: Las Américas: una población creciente urbana que está envejeciendo. 2004.

10. Sánchez RA, Ayala M, Baglivo H, Velázquez C, Burlando G, Kolmann O, Giménez J,Bendersky M et al, on be- half of the Latin American expert Group. Latin American guidelines on Hypertension. J Hypertens. 2009. 27: 905-922.

11. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr et al. The Seventh Report of the Joint National Committee on prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The JNC 7 report. JAMA 2003; 289:2560-2572.

12. Stamler J, Stamler R, Neaton JD: Blood pressure, systolic and diastolic, and cardiovascular risks. US population data. Arch Intern Med. 1993; 153: 598-615.; Hypertension: Pathophysiology, diagnosis, and management, vols 1 and 2 Ed: Laragh JH and Brenner DM. Published by: Raven Press, New York, 1995 pp: 127-144.).

13. Cuspidi C, Macca G, Sampieri L, Michev I, Salerno M, Fusi V, Severgnini B, Meani S, Magrini F, Zanchetti A. High prevalence of cardiac and extracardiac target organ damage in refractory hypertension. J Hypertens 2001; 19: 2063–2070.

14. Verdecchia P, Porcellati C, Schillaci G, et al. Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension. Hypertension 1994; 24(6): 793-801.

15. Pickering T, James GD, Boddie C, et. al How common is white coat hypertension? JAMA 1988; 259: 225-228.

16. Julius S, Mejia A, Jones K, Krause L, Sork N, Van de Ven C et al. White coat versus sustained borderlin Robles NR, Cancho B: Hipertensión de bata blanca. Nefrología 2002; 22 (Supl. 3): Mancia G, Facchetti R, Bomballi M, Grassi G, Sega R. Long-term risk of mortality associated with selective and combined elevation in office, home and ambulatory blood pressure. Hypertension 2006; 47: 846-853.

17. Ohkubo T, Kiluya M, Metoki H, Asayama K, Obara T, Hashimoto T, Totsuna K, Hoshi H, Saloli H, Imai Y. Prognosis of masked hypertension and white-coat hypertension detected by 24 h. ambulatory blood pressure monitoring. J Am Coll Cardiol 2005; 46: 508-515

18. Fagard RH, Den Broski G, De Cort P. Diagnostic significance of blood pressure measurement in the office, at home and during ambulatory monitoring in older patients in general population. J Hum Hypertens 2005; 19: 801-807.

19. Sorge R, Tromino G, Lanzarotti A, Carugo S, Casana G, Sciavoni R, Valaguesa F, Bombeli M, Giannatasio C, Zanchetti A, Mancia G. Alterations in cardiac structure in patients with isolated office, ambulatory or home hypertension. Data from the general PAMELA population. Circulation 2001; 1104: 1385-92.

20. Parati, G; Stergiou, G S; Asmar, R; Bilo, G; et al. European Society of Hypertension guidelines for blood pressure monitoring at home: a summary report of the Second International Consensus Conference on Home Blood Pressure Monitoring. J Hypertens 2008, 26: 1505-1526.

21. Palatini, P. Ambulatory blood pressure monitoring in clinical practice: is being superior good enough?. J Hypertens 2008, 26: 1300-1302.

22. White WB. Ambulatory blood pressure monitoring in clinical practice. N Engl J Med 2003; 348: 2377-2378.

23. O'Brien E, Asmar R, Beilin L, Imai Y, Mallion JM, Mancia G, et al.; European Society of Hypertension Working Group on Blood Pressure Monitoring. European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement. J Hypertens. 2003 May; 21[5]: 821-483; 348: 2377-2378.72-76, 2002

24. Lastra G, McFarlane SI, Sowers JR. Treatment of hypertensive patients with anbnormal blood glucose. In Izzo JL, Sica DA and Black HR. Hypertension Primer. Chap. C158, pp. 529-32.2010 25. The HOPE Study Investigators. Effects of an angiotensina-converting-enzyme inhibitor, ramipril, on cardiovascular events in high risk patients. N Engl J Med 2000;342:145-53.

26. UK Prospective Diabetes Study Group (UKPDS). Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes. BMJ 1998;317:703-13.

27. Stassen JA, Fagard R, Thijs L y cols. A randomised double blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet 1997;350:757-64.

28. HOT Study: Hansson L, Zanchetti A, Carruthers SG y cols. Effects of intensive blood pressure lowering and low dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998;351:1755-62.

29. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991;265:3255-64

30. A.H. Barnett Preventing renal complications in diabetic patients: the Diabetics Exposed to Telmisartan And enalaprIL (DETAIL) study Acta Diabetol (2005) 42:S42–S49.

31. Bakris G, Burgess E, Weir M, Davidai G, Koval S; AMADEO Study Investigators Telmisartan is more effective than losartan in reducing proteinuria in patients with diabetic nephropathy. Kidney Int. 2008 Aug;74(3):364-9.

32. The Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD). Effects of Intensive Glucose Lowering in Type 2 Diabetes. N Engl J Med 2008;358:2545-59.

33. Brenner BM, Cooper ME, De Zeeuw D y cols. The RENAAL Study Investigators. Effects of losartan on renal and cardiovascular outcomes in patients with type-2 diabetes and nephropathy. N Engl J Med 2001;345:861-9.

34. Lewis EJ, Hunsicker LG, Clarke WR y cols. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type-2 diabetes. N Engl J Med 2001;345:851-60.

35. Parving HH, Lehnert H, Bröchner-Mortensen J y cols. The effect of irbesartan on the development of diabetic nephropathy in patients with type-2 diabetes. The IRMA Group. N Engl J Med 2001;345:870-8.

36. NAVIGATOR Study Group, McMurray JJ, Holman RR, Haffner SM y cols. Effect of valsartan on the incidence of diabetes and cardiovascular events. N Engl J Med. 2010;362:1477-1490

37. Dahlöf B, Devereux RB, Kjeldsen SE y cols. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002;359:995-1003.

38. The ONTARGET Investigators. Telmisartan, ramipril, or both in patients with high risk for vascular events. N Engl J Med 2008;358:1547-59.

39. Savage PJ, Pressel, Curb JD y cols. Influence of long term, low dose, diuretic-based, antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension: The SHEP Cooperative Research Group. Arch Intern Med 1998;158:741-51.

40. ALLHAT officers and coordinators. Major outcomes in high risk Hypertensive Patients randomized to angiotensina convering enzyme inhibitor or calcium channel blocker vs diuretic. JAMA 2002; 288:2981-87.

41. Dalhöf B, Sever P, Poulter NR, y cols. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo Scandinavian Cardiac Outcomes Trial-Blood pressure lowering arm (ASCOT-BPLA): a multicentre randomised trial. Lancet 2005; 366:815-906.

42. Fujita, T. Mineralocorticoid Receptors, Salt-Sensitive Hypertension, and Metabolic Syndrome. Hypertension 2010;55;813-818

Descargas

Publicado

2013-06-08

Número

Sección

Revisiones de literatura

Cómo citar

1.
Bendersky M, Sánchez R. Hipertensión arterial en pacientes con diabetes mellitus tipo 2 revisión. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 2013 Jun. 8 [cited 2024 Dec. 28];70(2):83-90. Available from: https://revistas.unc.edu.ar/index.php/med/article/view/20243

Artículos similares

1-10 de 847

También puede Iniciar una búsqueda de similitud avanzada para este artículo.