An infrequent cause of cholestasis: morphine-induced cholestasis
DOI:
https://doi.org/10.31053/1853.0605.v79.n3.33738Keywords:
surgery, morphine, cholestasis, extrahepatic cholestasisAbstract
Introduction: Extrahepatic cholestasis by opiates is a very rare entity of which only case reports are recorded in the literature. Methods: We present the case of a patient who developed abdominal pain and cholestasis after consumption of high doses of morphine for pain management of her underlying disease, treated by laparoscopic surgery. Results: The patient evolved favorably in the postoperative period without bilirrhage and was discharged on the fifth day with bilirubin values within normal parameters. Conclusion: Sphincter of Oddi dysfunction syndrome secondary to long-term use of opioids is a very rare entity. However, it should be suspected in cases of extrahepatic cholestasis in which no stones or tumors are observed and in patients with long-term use of high-dose opiates either due to addiction or chronic pain treatment.
Downloads
References
1. Sharma V, Rana SS, Chaudhary V, Dhaka N, Manrai M, Sivalingam J, Sharma R, Dutta U, Bhasin DK. Opium-related sphincter of Oddi dysfunction causing double duct sign. Endosc Ultrasound. 2016 Jul-Aug;5(4):269-71. doi: 10.4103/2303-9027.187892.
2. Berger Z, Arcos M, Matamala F, Rojas C. Cólico biliar inducido por morfina [Morphine induced biliary pain. Case report]. Rev Med Chil. 2017 Mar;145(3):406-409. Spanish. doi: 10.4067/S0034-98872017000300018.
3. Afghani E, Lo SK, Covington PS, Cash BD, Pandol SJ. Sphincter of Oddi Function and Risk Factors for Dysfunction. Front Nutr. 2017 Jan 30;4:1. doi: 10.3389/fnut.2017.00001.
4. Mousavi S, Toussy J, Zahmatkesh M. Opium addiction as a new risk factor of sphincter of Oddi dysfunction. Med Sci Monit. 2007 Nov;13(11):CR528-531.
5. Sharma SS. Sphincter of Oddi dysfunction in patients addicted to opium: an unrecognized entity. Gastrointest Endosc. 2002 Mar;55(3):427-30. doi: 10.1067/mge.2002.121600.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Universidad Nacional de Córdoba
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The generation of derivative works is allowed as long as it is not done for commercial purposes. The original work may not be used for commercial purposes.
How to Cite
