De los factores de riesgo de enfermedad arterial a la placa ateromatosa detección de la placa de alto riesgo
Keywords:
Oxidative power, Atheroma plaques, Risk, Determining content or composition, Cuagulation cascade, New diagnostic methodsAbstract
The atherosclerosis is a pathologic phenomena which is caraeterized by the stiffnes and enlargernent of the arterial valls due to the deposit of lipici carbohidratcs, blood products and caleiuni tato Wc subendothelial space. The risk factors of arterial discases inakes their inpact in all arteries of [he human body. It is clear to day that the cornposition of the plaque, is the major dcterrninant for its risk of rupture and for its logie consequence: thrombosis. Following plaque rupture, lipidie core and its high content of factors, gives a powerfui substratc for the activation of the coagulation cascade. It has been significant advances in the comprehension of the mechanism involved in the developmcnt of this disease and there is a large nuniber of evidences that the composition of the plaque is a major c!eterminant factor in the begining and n the severity of [he acute coronary syndrome. In consequence, the capacity [o identify [he aboye mentioned composition, monitoring its progression, are valuahie information for the development of acute coronary syndrorne. The converitiorial angiocoronariography taus to predict acute episodes, in such a way thai it has lost the value as a goid standard for [he detection of this syndrome and this failing promotes researchers to develop new methods, invasive and non-invasive to recognize the higly risk atherosclerotic plaque and the sick arcas for ideal and rapid interventions.
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