La restricción dietaria de calcio produce alteraciones metabólicas

Autores/as

  • Ana M. Marchionatti Universidad Nacional de Córdoba. Facultad de Ciencias Médicas.
  • Viviana A. Centeno Universidad Nacional de Córdoba. Facultad de Ciencias Médicas.
  • Gabriela E. Díaz de Barboza Universidad Nacional de Córdoba. Facultad de Ciencias Médicas.
  • Valeria A. Rodríguez Universidad Nacional de Córdoba. Facultad de Ciencias Médicas.
  • Nori G. Tolosa de Talamoni Universidad Nacional de Córdoba. Facultad de Ciencias Médicas.

DOI:

https://doi.org/10.31053/1853.0605.v66.n2.23532

Palabras clave:

dietas deficientes en calcio, metabolismo hormonal, cáncer, hueso

Resumen

El calcio (Ca2+) es fundamental para la formación de los huesos y dientes y es esencial para alcanzar el pico de masa ósea. Además, el Ca2+ es un importante regulador de diferentes procesos fisiológicos. Los requerimientos diarios de Ca2+ dependen de la edad, sexo y diferentes estados fisiológicos, siendo mayores en los adolescentes, en el embarazo y en la lactancia. Con dietas deficientes en Ca2+, la secreción de distintas hormonas calciotrópicas se modifica y el transporte duodenal y la reabsorción renal del catión se incrementan, por lo que el metabolismo óseo también está fuertemente alterado. Hay también evidencias de que existe asociación entre la baja ingesta de Ca2+ y la hipertensión arterial e incremento en el riesgo de contraer cáncer.

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Ana M. Marchionatti, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas.

Laboratorio de Metabolismo Fosfocálcico “Dr. F. Cañas”, Cátedra de Bioquímica y Biología Molecular, Ciencias Médicas,
UNC. 2º Piso, Pabellón Argentina, Ciudad Universitaria.

Viviana A. Centeno, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas.

Laboratorio de Metabolismo Fosfocálcico “Dr. F. Cañas”, Cátedra de Bioquímica y Biología Molecular, Ciencias Médicas,
UNC. 2º Piso, Pabellón Argentina, Ciudad Universitaria.

Gabriela E. Díaz de Barboza, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas.

Laboratorio de Metabolismo Fosfocálcico “Dr. F. Cañas”, Cátedra de Bioquímica y Biología Molecular, Ciencias Médicas,
UNC. 2º Piso, Pabellón Argentina, Ciudad Universitaria.

Valeria A. Rodríguez, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas.

Laboratorio de Metabolismo Fosfocálcico “Dr. F. Cañas”, Cátedra de Bioquímica y Biología Molecular, Ciencias Médicas,
UNC. 2º Piso, Pabellón Argentina, Ciudad Universitaria.

Nori G. Tolosa de Talamoni, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas.

Laboratorio de Metabolismo Fosfocálcico “Dr. F. Cañas”, Cátedra de Bioquímica y Biología Molecular, Ciencias Médicas,
UNC. 2º Piso, Pabellón Argentina, Ciudad Universitaria.

Citas

Ma, J, Johns, RA, Stafford, RS: Americans are not meeting current calcium recommendations. Am J Clin Nutr; 2007, 85: 1361-1366.

Petre-Lazar, B, Livera, G, Moreno, SG, Trautmann, E, Duquenne, C, Hanoux, V, Habert, R, Coffigny, H: The role of p63 in germ cell apoptosis in the developing testis. J Cell Physiol; 2007, 210: 87-98.

Kranz, S, Lin, PJ, Wagstaff, DA: Children’s dairy intake in the United States: too little, too fat?. J Pedriatr; 2007, 151: 642-646.

Bhatia, V: Dietary calcium intake – a critical reappraisal. Indian J Med Res; 2008, 127: 269-273.

Pérez, A, Ulla, M, García, B, Lavezzo, M, Elías, E, Binci, M, Rivoira, M, Centeno, V, Alisio, A, Tolosa de Talamoni, N: Genotypes and clinical aspects associated with bone mineral density in Argentine postmenopausal women. J Bone Miner Metab; 2008, 26: 358-365.

Centeno, VA, Díaz de Barboza, GE, Marchionatti, AM, Alisio, AE, Dallorso, ME, Nasif, R, Tolosa de Talamoni, NG: Dietary calcium deficiency increases Ca2+ uptake and Ca2+ extrusion mechanisms in chick enterocytes. Comp Biochem Physiol A; 2004, 139: 133-141.

Centeno, V, Díaz Barboza, G, Marchionatti, A, Rodriguez, V, and Tolosa de Talamoni N: Molecular mechanisms triggered by low-calcium diets. Nutr Res Rev; 2009, 22: 163-74.

Tolosa de Talamoni, N, Centeno V: Low calcium diets in humans and in experimental animals: classics models to understand calcium homeostasis and vitamin D endocrine systems. Endocrinologia; 1999, 46: 241-244.

Swaminathan, R, Sommerville, BA, Care, AD: The effect of dietary calcium on the activity of 25-hydroxycholecalciferol- 1-hydroxylase and Ca absorption in vitamin D-replete chicks. Br J Nutr; 1997, 38: 47-54.

Schedl, HP, Conway, T, Horst, RL, Miller, DL, Brown, CK: Effects of dietary calcium and phosphorus on vitamin D metabolism and calcium absorption in hamster. Proc Soc Exp Biol Med; 1996, 211: 281-286.

Stumpf, WE: Vitamin D and the digestive system. Eur J Drug Metab Pharmacokinet.; 2008, 33: 85-100.

Fleet, JC, Gliniak, C, Zhang, Z, Xue, Y, Smith, KB, McCreedy, R, Adedokun, SA: Serum metabolite profiles and target tissue gene expression define the effect of cholecalciferol intake on calcium metabolism in rats and mice. J Nutr; 2008, 138: 1114-1120.

Christakos, S, Dhawan, P, Liu, Y, Peng, X, Porta, A: New insights into the mechanisms of vitamin D action. J Cell Biochem; 2003, 88: 695-705.

Pasch, A, Frey, FJ, Eisenberger, U, Mohaupt, MG, Bonny, O: PTH and 1.25 vitamin D response to a lowcalcium diet is associated with bone mineral density in renal stone formers. Nephrol Dial Transplant; 2008, 23: 2563-2570.

Díaz, R, El-Hajj, G, Brown, E: Parathyroid hormone and poly hormones: production and export. In Handbook of physiology: endocrine regulation of water and electrolyte balance. 2000: pp. 607-662 [Y Fray, editor]. New York, Oxford University Press.

Miao, D, Li, J, Xue, Y, Su, H, Karaplis, AC, Goltzman, D: Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice. Endocrinology; 2004, 145: 3554-3562.

Zhang, Y, Lai, WP, Wu, CF, Favus, MJ, Leung, PC, Wong, MS: Ovariectomy worsens secondary hyperparathyroidism in mature rats during low-Ca diet. Am J Physiol Endocrinol Metab; 2007, 292: E723-E731.

Canaff, L, Zhou, X, Hendy, GN: The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3. J Biol Chem; 2008, 283: 13586 - 13600.

Ferrari, S, Bonjour, JP, Rizzoli, R: The vitamin D receptor gene and calcium metabolism. Trends Endocrinol Metab; 1998, 9: 259-265.

Tolosa de Talamoni, N, Mykkanen, H, Wasserman, R: Enhancement of sulfhydryl groups availability in the intestinal brush border membrane by deficiencies of dietary calcium and phosphorus in chicks. J Nutr; 1990, 20: 1198-1204.

Mykkanen, HM, Wasserman, RH: Uptake of 75Seselenite by brush border membrane vesicles from chick duodenum stimulated by vitamin D. J Nutr; 1989, 119: 242-247.

Benn, BS, Ajibade, D, Porta, A, Dhawan, P, Hediger, M, Peng, JB, Jiang, Y, Oh, GT, Jeung, EB, Lieben, L, Bouillon, R, Carmeliet, G, Christakos, S: Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology; 2008, 149: 3196-3205.

Murayama, A, Takeyama, K, Kitanaka, S, Kodera, Y, Kawaguchi, Y, Hosoya, T, Kato, S: Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals. Endocrinology; 1999, 140: 2224-2231.

Omdahl, JL, Morris, HA, May, BK: Hydroxylase enzymes of the vitamin D pathway: expression, function, and regulation. Annu Rev Nutr; 2002, 22: 139-166.

Pasch, A, Frey, FJ, Eisenberger, U, Mohaupt, MG, Bonny, O: PTH and 1.25 vitamin D response to a lowcalcium diet is associated with bone mineral density in renal stone formers. Nephrol Dial Transplant; 2008, 23: 2563-2570.

Kalkwarf, HJ, Khoury, JC, Lanphear, BP: Milk intake during childhood and adolescence, adult bone density, and osteoporotic fractures in US women. Am J Clin 27. Kasukawa, Y, Baylink, DJ, Wergedal, JE, Amaar, Y, Srivastava, AK, Guo, R, Mohan, S: Lack of insulin-like growth factor I exaggerates the effect of calcium deficiency on bone accretion in mice. Endocrinology; 2003, 144: 4682-4689.

Bezerra, FF, Mendonça, LM, Lobato, EC, O'Brien, KO, Donangelo, CM: Bone mass is recovered from lactation to postweaning in adolescent mothers with low calcium intakes. Am J Clin Nutr; 2004, 80: 1322-1326.

Avenell, A, Gillespie, WJ, Gillespie, LD, O'Connell, D: Vitamin D and vitamin D analogues for preventing fractures associated with involutional and postmenopausal osteoporosis. Cochrane Database Syst Rev; 2009, 2.

Bucher, HC, Guyatt, GH, Cook, RJ, Hatala, R, Cook, DJ, Lang, JD, Hunt, D: Effect of calcium suplementation on pregnancy-induced hypertension and preeclampsia: a meta- analysis of randomized controlled trails. JAMA; 1996, 275: 1113-1117.

Wang, L, Manson, JE, Buring, JE Lee, IM, Sesso, HD: Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension; 2008, 51: 1073-1079.

Murtaugh, MA, Sweeney, C, Ma, KN, Potter, JD, Caan, BJ, Wolff, RK, Slattery, ML: Vitamin D receptor gene polymorphisms, dietary promotion of insulin resistance, and colon and rectal cancer. Nutr Cancer; 2006, 55: 35 – 43.

Levi, F, Pasche, C, Lucchini, F et al. Selected micronutrients and colorectal cancer. a case-control study from the canton of Vaud, Switzerland. Eur J Cancer; 2000, 36: 2115-2129.

Farrow, DC, Davis, S: Diet and the risk of pancreatic cancer in men. Am J Epidemiol; 1990, 132: 423- 431.

Torniainen, S, Hedelin, M, Autio, V, Rasinperä, H, Bälter, KA, Klint, A, Bellocco, R, Wiklund, F, Stattin, P, Ikonen, T, Tammela, TL, Schleutker, J, Grönberg, H, Järvelä, I.: Lactase persistence, dietary intake of milk, and the risk for prostate cancer in Sweden and Finland. Cancer Epidemiol Biomarkers Prev; 2007, 16: 956-961.

Bonjour, JP, Chevalley, T, Fardellone, P: Calcium intake and vitamin D metabolism and action, in healthy conditions and in prostate cancer. Br J Nutr; 2007, 97: 611-616.

Skinner, HG, Michaud, DS, Giovannucci, E, Willett, WC, Colditz, GA, Fuchs, CS: Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomarkers Prev; 2006, 15: 1688-1695.

Kuokkanen, M, Butzow, R, Rasinperä, H, Medrek, K, Nilbert, M, Malander, S, Lubinski, J, Järvelä, I: Lactase persistence and ovarian carcinoma risk in Finland, Poland and Sweden. Int J Cancer; 2005, 117: 90-94.

Descargas

Publicado

2009-07-25

Cómo citar

1.
Marchionatti AM, Centeno VA, Díaz de Barboza GE, Rodríguez VA, Tolosa de Talamoni NG. La restricción dietaria de calcio produce alteraciones metabólicas. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 25 de julio de 2009 [citado 28 de abril de 2024];66(2):66-72. Disponible en: https://revistas.unc.edu.ar/index.php/med/article/view/23532

Número

Sección

Revisiones de literatura