Relação entre marcadores inflamatórios e gravidade da da síndrome de apneia do sono e hipopnéia
DOI:
https://doi.org/10.31053/1853.0605.v78.n2.30397Palavras-chave:
Síndromes da Apneia do Sono, Biomarcadores, InflamaçãoResumo
INTRODUÇÃO: A hipóxia crônica intermitente produzida durante as apneias obstrutivas do sono (AOS) leva ao estresse oxidativo e, consequentemente, a um estado de inflamação sistêmica. Não existem biomarcadores que avaliem o grau de inflamação e estejam relacionados com a gravidade da doença. A largura de distribuição eritrocitária (LDE) e a proteína C reativa ultrassensível (PCRus) são sensíveis à inflamação sistêmica gerada pelo estresse oxidativo. Pretendemos correlacionar os valores de PCR e LDE com o grau de gravidade da SAOS.
MÉTODOS: Foi realizado um estudo observacional, prospectivo e analítico. Pacientes com AOS participaram. Para estimar a correlação entre LDE e PCR com a gravidade da AOS de acordo com o IAH, foi utilizado o coeficiente de correlação de Spearman.
RESULTADOS: Participaram 95 pacientes, dos quais 79 eram homens. Apenas 10 (10,5%) pacientes apresentavam IMC normal. As correlações entre IAH com PCR e LDE foram fracas (r = 0,17; p = 0,1066 er = 0,06; p = 0,5867, respectivamente). As correlações entre T90 com PCR e LDE também foram fracas (r = 0,16; p = 0,1331 er = 0,24; p = 0,0202, respectivamente). Foi encontrada associação entre LDE maior que 14 e AOS grave (p = 0,0369) e entre LDE maior que 14 e T90 maior que 10% (p = 0,0168).
CONCLUSÕES: Embora as correlações entre IAH e T90 com PCR e RDW sejam fracas, verificou-se que pacientes graves apresentaram maiores valores de RDW e maior T <90. Esta associação não pode ser comprovada com PCR.
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