Relationship between the values of specific prostate antigen and the score de Gleason in the adenocarcinoma acinar cell of prostate

Abstract

Currently, prostate adenocarcinoma is considered a health problem of great relevance since it constitutes the second cause of morbidity and mortality among men over 50 in the Western Hemisphere. One of the methods for its early detection is to determine the serum values ​​of the prostate antigen. The tumor histological grade in these neoplasms constitutes a prognostic factor for therapeutic decision making.  

The objective of this investigation was to determine the relationship between the Gleason Score and the values ​​of prostate specific antigen in biopsies of invasive acinar adenocarcinoma of the prostate.

This is an observational, cross-sectional, retrospective and population-based study, where 78 cases of prostate biopsies obtained from the archives of the Service and 1st Pathology Department of the National Hospital of Clinics, of the city of Córdoba, were selected puncture between July 2017 and May 2019 with a diagnosis of invasive acinar adenocarcinoma of the prostate, which presented a complete clinical history performed in said hospital, together with a thorough physical examination.

Of the 78 cases analyzed, 29 presented a diagnosis of invasive acinar adenocarcinoma of the prostate with a high Gleason Score of 8 or more. They were related to a specific prostate antigen value above 10 ng / dl (72%). Furthermore, it was observed that in those cases in which the antigen values ​​were high and had an adenocarcinoma with a Gleason score below 6 (67%), they were related to varying degrees of exacerbated chronic prostatitis.

The realization of this work allows to establish that a high value of prostate specific antigen could be related to a high Gleason Score and therefore this determination would have predictive value of the prognosis in this variant of prostate carcinoma.