Maternal factors associated to congenital transmission of Chagas disease in children born and siblings in Chaco province, Argentina
DOI:
https://doi.org/10.31053/1853.0605.v75.n4.21260Keywords:
chagas disease, trypanosoma cruzi infections, infectious disease transmission, vertical- disease neglectedAbstract
Introduction. After vector-borne transmission, the congenital form is the most important to maintain the endemic. The probability of congenital transmission may depend on factors that vary between different countries and geographic areas. This study was carried out with the objective of estimating the proportion of congenital transmission of Chagas disease and maternal factors associated to the T. cruzi infection in newborns and their siblings during 2011 in four hospitals of the Province of Chaco. Methods. A cross sectional study was performed. A home visit was made to children aged above 10 months born during 2011 whom their mother present T cruzi infection. Blood samples were taken from both the newborns and their siblings and were processed for diagnosis of T. cruzi infection with HAI and ELISA. We found 247 mothers infected with T cruzi, and blood samples were obtained from 246 newborns and 556 of their siblings. Results. Of the 246 children born in 2011, a total of 6.1% (95% CI = 3.6-9.6) resulted with positive serology, as well as 7.7% of their siblings (95% CI = 5.7-10.1) and the clinic visits of those born in 2011 and their siblings in the health center was associated with a lower probability of congenital transmission (OR = 0.21 and 0.36, respectively). Conclusion. The transmission rate is consistent with the values reported in Argentina and only multiparity was a mother factor associated with the higher probability of congenital transmission.
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References
1. Bern C. Chagas’ disease. New England Journal of Medicine. 2015;373(5):456-466.
2. Coalición Global de la Enfermedad de Chagas. Rompiendo el silencio; Una oportunidad para los pacientes de Chagas. Abril 2016. https://www.isglobal.org/documents/10179/5353835/Rompiendo+el+silencio+-+Chagas-+170117/402acb9d-9373-49c7-8800-c9bdb5c4e871.
3. Nación MdSdl. El Chagas en el país y América Latina. 2012; http://www.msal.gob.ar/chagas/index.php/informacion-para-ciudadanos/el-chagas-en-el-pais-y-america-latina. Accessed December 2017.
4. Freilij H, Biancardi M, Lapeña A, Ballering G, Altcheh J. Enfermedad de Chagas congénita. Chagas en el Siglo XXI. De la enfermedad a la problemática social. 2010:117-125.
5. Programa Nacional de Chagas MdSdlN. Síntesis de la guía de diagnóstico y tratamiento de pacientes con Enfermedad de Chagas. 2012.
6. Martins-Melo FR, Lima Mda S, Ramos AN, Jr., Alencar CH, Heukelbach J. Prevalence of Chagas disease in pregnant women and congenital transmission of Trypanosoma cruzi in Brazil: a systematic review and meta-analysis. Tropical medicine & international health : TM & IH. Aug 2014;19(8):943-957.
7. Rassi Jr A, Rassi A, Marin-Neto JA. Chagas disease. The Lancet. 2010;375(9723):1388-1402.
8. Genero SC, Raúl; Gorestegui, Federico; Bonanno, Daniela; Rodriguez Llach, Andrea; Somoza, Matías; Prieto, Fernando; Sánchez Negrete, Luz; Martínez, Andrea; Robles, María; Risso, Mario. Transmisión congénita de la enfermedad de Chagas en el departamento de San Fernando, Provincia del Chaco Rev. argent. salud publica. 2012;3:19:23.
9. Spillmann C, Burrone S, Coto H. Análisis de la situación epidemiológica de la enfermedad de Chagas en Argentina: avances en el control, 2012. Rev. argent. salud publica. 2013;4(15):40-44.
10. Ortí Lucas RM, Parada Barba MC. Prevalencia de tripanomiasis americana en mujeres gestantes de un área de salud: Valencia, 2005-2007. Revista Española de Salud Pública. 2009;83(4):543-555.
11. Lucero RH, Brusés BL, Merino DE, Fernández GJ, Crenna EC, Alonso JM. Enfermedad de Chagas congénito en Hospitales de la ciudad de Corrientes-Argentina. Enferm. emerg. 2007:121-124.
12. Sánchez Negrette O, Zaidenberg M, Monteros MC, Acevedo A, Linares V, Freilij H. Prevalencia de infección por Trypanosoma cruzi en escolares de Salta y Chaco, Argentina. Acta bioquímica clínica latinoamericana. 2017;51(4):687-694.
13. Kaplinski M, Jois M, Galdos-Cardenas G, et al. Sustained domestic vector exposure is associated with increased Chagas cardiomyopathy risk but decreased parasitemia and congenital transmission risk among young women in Bolivia. Clinical Infectious Diseases. 2015;61(6):918-926.
14. Cardoso EJ, Valdéz GC, Campos AC, et al. Maternal fetal transmission of Trypanosoma cruzi: a problem of public health little studied in Mexico. Experimental parasitology. 2012;131(4):425-432.
15. Luquetti AO, Tavares SBdN, Siriano LdR, et al. Congenital transmission of Trypanosoma cruzi in central Brazil. A study of 1,211 individuals born to infected mothers. Memórias do Instituto Oswaldo Cruz. 2015;110(3):369-376.
16. Cucunuba ZM, Florez AC, Cardenas A, et al. Prevalence and risk factors for Chagas disease in pregnant women in Casanare, Colombia. Am J Trop Med Hyg. Nov 2012;87(5):837-842.
17. Sasagawa E, Aiga H, Corado EY, et al. Risk factors for Chagas disease among pregnant women in El Salvador. Tropical medicine & international health : TM & IH. Mar 2015;20(3):268-276.
18. Brutus L, Castillo H, Bernal C, et al. Detectable Trypanosoma cruzi parasitemia during pregnancy and delivery as a risk factor for congenital Chagas disease. Am J Trop Med Hyg. Nov 2010;83(5):1044-1047.
19. Carlier Y, Sosa-Estani S, Luquetti AO, Buekens P. Congenital Chagas disease: an update. Memórias do Instituto Oswaldo Cruz. 2015;110(3):363-368.
20. Sosa-Estani S, Cura E, Velazquez E, Yampotis C, Segura EL. Etiological treatment of young women infected with Trypanosoma cruzi, and prevention of congenital transmission. Revista da Sociedade Brasileira de Medicina Tropical. 2009;42(5):484-487.
21. Salas NA, Cot M, Schneider D, et al. Risk factors and consequences of congenital Chagas disease in Yacuiba, south Bolivia. Tropical medicine & international health : TM & IH. Dec 2007;12(12):1498-1505.
22. Klein K, Burrone MS, Alonso JP, et al. Estrategia para mejorar el acceso al tratamiento etiológico para la enfermedad de Chagas en el primer nivel de atención en Argentina. Revista Panamericana de Salud Pública. 2017;41:e20.
23. De Rissio AM, Riarte AR, García MM, Esteva MI, Quaglino M, Ruiz AM. Congenital Trypanosoma cruzi infection. Efficacy of its monitoring in an urban reference health center in a non-endemic area of Argentina. The American journal of tropical medicine and hygiene. 2010;82(5):838-845.
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