La importancia del laboratorio en el diagnóstico del síndrome de Sjögren primario

Pilar Brito-Zerón; Albert Bove; Marta Perez-de-Lis; Candido Diaz-Lagares; Myriam Gandía; Miriam Akasbi; María José Soto-Cardenas

doi:10.31053/1853.0605.v66.n1.23537

Autores/as

Pilar Brito-Zerón Laboratorio de Enfermedades Autoinmunes Josep Font, Servicio de Enfermedades Autoinmunes, IDIBAPS, Hospital Clínic, Barcelona.
Albert Bove Laboratorio de Enfermedades Autoinmunes Josep Font, Servicio de Enfermedades Autoinmunes, IDIBAPS, Hospital Clínic, Barcelona.
Marta Perez-de-Lis Laboratorio de Enfermedades Autoinmunes Josep Font, Servicio de Enfermedades Autoinmunes, IDIBAPS, Hospital Clínic, Barcelona.
Candido Diaz-Lagares Laboratorio de Enfermedades Autoinmunes Josep Font, Servicio de Enfermedades Autoinmunes, IDIBAPS, Hospital Clínic, Barcelona.
Myriam Gandía Laboratorio de Enfermedades Autoinmunes Josep Font, Servicio de Enfermedades Autoinmunes, IDIBAPS, Hospital Clínic, Barcelona.
Miriam Akasbi Laboratorio de Enfermedades Autoinmunes Josep Font, Servicio de Enfermedades Autoinmunes, IDIBAPS, Hospital Clínic, Barcelona.
María José Soto-Cardenas Laboratorio de Enfermedades Autoinmunes Josep Font, Servicio de Enfermedades Autoinmunes, IDIBAPS, Hospital Clínic, Barcelona.

DOI:

https://doi.org/10.31053/1853.0605.v66.n1.23537

Palabras clave:

Síndrome de Sjögren, enfermedad crónica, enfermedades del aparato lagrimal, xeroftalmia, xerostomía

Resumen

El síndrome de Sjögren (SS) es una enfermedad autoinmune sistémica que se caracteriza fundamentalmente por la presencia de xeroftalmía y xerostomía debido a la infiltración de las glándulas lagrimales y salivares por células linfoplasmocitarias. Al igual que en otras enfermedades autoinmunes sistémicas, las alteraciones hematológicas no son raras dentro del SS, e incluso pueden ser la primera manifestación en algunos pacientes. Por otra parte, la determinación sérica de diversas proteínas circulantes puede ser importante en el seguimiento clínico de estos pacientes, y datos analíticos como la hipergammaglobulinemia policlonal o la existencia de una velocidad de sedimentación globular (VSG) elevada, pueden orientar al diagnóstico de SS. Finalmente, la importancia del análisis del perfil inmunológico juega un papel esencial en el diagnóstico del paciente con SS primario.

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