Doença de coronavírus (COVID-19) e sirtuínas
DOI:
https://doi.org/10.31053/1853.0605.v77.n2.28196Palavras-chave:
Infecções por Coronavirus, neoplasias, Inibidores de Histona, Desacetilases, NAD, SirtuinasResumo
As proteínas desacetilases dependentes de NAD + são chamadas Sirtuins (SIRT).
Objetivos: destarevisão é estudar as sirtuínas envolvidas no câncer, bem como estudos de inibição da SIRT1 em pacientes com doença de coronavírus COVID-19.
Fonte e seleção dos dados: Para isso, foi realizada uma pesquisa no Medline, Scopus e WOS, onde foram incluídos estudos descritivos de cada uma das funções das sirtuínas, ajustados às pesquisas científicas recentes. À inibição da SIRT1 diminui a citotoxicidade das células T CD8 em pacientes com Lúpus Eritematoso Sistêmico sendo suscetível a infecções por SARS Cov-2. O SIRT2 é regulado pela secreção de IL-4 pelos eosinófilos e o aumento do SIRT2 aumenta a hiperplasia, enquanto o SIRT3 promove a angiogênese, induzindo a remodelação cardíaca. SIRT4 é um supressor de tumor, em contraste com o SIRT5, que promove a proliferação celular causando cáncer colorretal; O SIRT6 atenua o vírus do herpes associadoao Sarcoma de Kaposi (KSHV) em pacientes imunocomprometidos. A supressão de SIRT7 inibe o crescimento de células cancerígenas endometriais.
Conclusões: Conclui-se que SIRT1, SIRT2 e SIRT4 estão envolvidos no desenvolvimento do câncer, a supressão de SIRT5 e SIRT7 promove a apoptose das células cancerígenas e o SIRT6 atenua a replicação do KSHV, alémdisso, a via da patologia molecular do COVID-19 é associado à inibição da atividade da SIRT1 que pode estar relacionada a procesos inflamatórios.
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