Celiac disease and primary hyperparathyroidism
an infrequent association
DOI:
https://doi.org/10.31053/1853.0605.v80.n4.42137Keywords:
celiac disease, hyperparathyroidism primary, osteoporosisAbstract
Objective. Primary hyperparathyroidism (PHPT) and celiac disease (CD) are two distinct medical conditions that can affect bone health. While PHPT leads to excessive calcium levels and bone abnormalities, CD impairs calcium and vitamin D absorption due to small intestine damage. Case report. We present a case of a 49-year-old woman diagnosed with osteoporosis who was found to have both PHPT and CD. The patient underwent a successful minimally invasive parathyroidectomy, which resulted in decreased parathyroid hormone levels. Conclusion. This case highlights the rare coexistence of PHPT and CD and emphasizes the importance of considering secondary causes of osteoporosis in patients with low bone mass. Further studies are needed to explore the underlying mechanisms and potential links between PHPT and CD.
Downloads
References
Bilezikian JP. Primary Hyperparathyroidism. J Clin Endocrinol Metab. 2018 Nov 1;103(11):3993-4004. doi: 10.1210/jc.2018-01225.
Lebwohl B, Sanders DS, Green PHR. Coeliac disease. Lancet. 2018 Jan 6;391(10115):70-81. doi: 10.1016/S0140-6736(17)31796-8.
Leffler DA, Green PH, Fasano A. Extraintestinal manifestations of coeliac disease. Nat Rev Gastroenterol Hepatol. 2015 Oct;12(10):561-71. doi: 10.1038/nrgastro.2015.131.
Zanchetta MB, Longobardi V, Bai JC. Bone and Celiac Disease. Curr Osteoporos Rep. 2016 Apr;14(2):43-8. doi: 10.1007/s11914-016-0304-5.
Maida MJ, Praveen E, Crimmins SR, Swift GL. Coeliac disease and primary hyperparathyroidism: an association? Postgrad Med J. 2006 Dec;82(974):833-5. doi: 10.1136/pgmj.2006.045500.
Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB. American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis- 2020 Update Executive Summary. Endocr Pract. 2020 May;26(5):564-570. doi: 10.4158/GL-2020-0524.
Harper KD, Weber TJ. Secondary osteoporosis. Diagnostic considerations. Endocrinol Metab Clin North Am. 1998 Jun;27(2):325-48. doi: 10.1016/s0889-8529(05)70008-6.
Favus MJ. Postmenopausal osteoporosis and the detection of so-called secondary causes of low bone density. J Clin Endocrinol Metab. 2005 Jun;90(6):3800-1. doi: 10.1210/jc.2005-0784.
Vestergaard P, Mosekilde L. Fractures in patients with primary hyperparathyroidism: nationwide follow-up study of 1201 patients. World J Surg. 2003 Mar;27(3):343-9. doi: 10.1007/s00268-002-6589-9.
Hansen S, Hauge EM, Rasmussen L, Jensen JE, Brixen K. Parathyroidectomy improves bone geometry and microarchitecture in female patients with primary hyperparathyroidism: a one-year prospective controlled study using high-resolution peripheral quantitative computed tomography. J Bone Miner Res. 2012 May;27(5):1150-8. doi: 10.1002/jbmr.1540.
Valdimarsson T, Toss G, Löfman O, Ström M. Three years' follow-up of bone density in adult coeliac disease: significance of secondary hyperparathyroidism. Scand J Gastroenterol. 2000 Mar;35(3):274-80. doi: 10.1080/003655200750024146.
Zylberberg HM, Lebwohl B, RoyChoudhury A, Walker MD, Green PHR. Predictors of improvement in bone mineral density after celiac disease diagnosis. Endocrine. 2018 Feb;59(2):311-318. doi: 10.1007/s12020-017-1488-x.
Alzahrani AS, Al Sheef M. Severe primary hyperparathyroidism masked by asymptomatic celiac disease. Endocr Pract. 2008 Apr;14(3):347-50. doi: 10.4158/EP.14.3.347.
Fanciulli G, Delitala AP, Usai CA, Delitala G. Primary hyperparathyroidism revealed by gluten-free diet in a woman with celiac disease. Intern Emerg Med. 2012 May;7 Suppl 1:S37-8. doi: 10.1007/s11739-011-0604-9.
Ludvigsson JF, Kämpe O, Lebwohl B, Green PH, Silverberg SJ, Ekbom A. Primary hyperparathyroidism and celiac disease: a population-based cohort study. J Clin Endocrinol Metab. 2012 Mar;97(3):897-904. doi: 10.1210/jc.2011-2639.
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Universidad Nacional de Córdoba
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The Faculty of Medical Sciences Journal (RFCM) subscribes to the Open Access policy and does not charge authors fees for publishing, nor does it charge readers fees for accessing published articles (APC).
