Relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome.

Authors

  • Fernando Astur Camporro Clinica Universitaria Reina Fabiola https://orcid.org/0000-0002-3060-1128
  • Gregorio Varujan Kevorkof Servicio de Neumonología, Clínica Universitaria Reina Fabiola
  • Ana Gallmann Servicio de clinica medica, Clinica Universitaria Reina Fabiola
  • Florencia Gazzoni Servicio de Clínica Medica, Clínica Universitaria Reina Fabiola
  • Exequiel Bulacio Servicio de Clínica Medica, Clínica Universitaria Reina Fabiola
  • Ignacio Gutierrez Magaldi Servicio de Clínica Medica, Clínica Universitaria Reina Fabiola
  • Eduardo Borsini Servicio de Neumonologia, Hospital Britanico de Buenos Aires https://orcid.org/0000-0003-2930-6022

DOI:

https://doi.org/10.31053/1853.0605.v78.n2.30397

Keywords:

Sleep Apnea Syndromes, Biomarkers, Inflammation

Abstract

INTRODUCTION: Intermittent chronic hypoxia produced during obstructive sleep apneas (OSA) leads to oxidative stress, and consequently to a state of systemic inflammation. There are no biomarkers that assess the degree of inflammation and are related to the severity of this disease. The red cell distribution amplitude and the ultrasensitive reactive C protein are sensitive to the systemic inflammation generated by oxidative stress. We intend to correlate the reactive C protein and red cell distribution amplitude values ​​with the degree of severity of OSA.

 METHODS: An observational, prospective, analytical study was performed. OSA patients participated. Spearman's correlation coefficient was used to estimate the correlation between red cell distribution amplitude and reactive C protein with OSA severity according to apnea hypopnea index (AHI).

 RESULTS: 95 patients participated, of which 79 were men. Only 10 (10.5%) patients presented normal BMI. The correlations between AHI with reactive C protein and red cell distribution amplitude were weak (r = 0.17; p = 0.1066 and r = 0.06; p = 0.5867, respectively). The correlations between T90 with reactive C protein and red cell distribution amplitude were also weak (r = 0.16; p = 0.1331 and r = 0.24; p = 0.0202, respectively). An association was found between red cell distribution amplitude greater than 14 and severe OSA (p = 0.0369) and with T90 greater than 10% (p = 0.0168).

CONCLUSIONS: Although the correlations between AHI and T90 with reactive C protein and red cell distribution amplitude were weak, it was found that severe patients, presented higher values ​​of red cell distribution amplitude and higher T <90. This association could not be tested with reactive C protein.

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Author Biographies

Fernando Astur Camporro, Clinica Universitaria Reina Fabiola

Médico especialista en medicina interna y neumonología. Staff de los servicios de clínica médica y neumonología de la Clínica Universitaria Reina Fabiola, Universidad Catolica de Cordoba. 

Gregorio Varujan Kevorkof, Servicio de Neumonología, Clínica Universitaria Reina Fabiola

Médico especialista en medicina interna y neumonología. Profesor titular de la catedra de clínica médica II, FCM.UNC. Jefe del servicio de neumonologia Clínica Universitaria Reina Fabiola.

Ana Gallmann, Servicio de clinica medica, Clinica Universitaria Reina Fabiola

Médica especialista en medicina interna. Clínica Universitaria Reina Fabiola.

Florencia Gazzoni, Servicio de Clínica Medica, Clínica Universitaria Reina Fabiola

Médica especialista en medicina interna. Clínica Universitaria Reina Fabiola.

Exequiel Bulacio , Servicio de Clínica Medica, Clínica Universitaria Reina Fabiola

Médico especialista en medicina interna. Clínica Universitaria Reina Fabiola. Profesor universitario Universidad Catolica de Cordoba. 

Ignacio Gutierrez Magaldi, Servicio de Clínica Medica, Clínica Universitaria Reina Fabiola

Médico especialista en medicina interna. Clínica Universitaria Reina Fabiola. Profesor universitario Universidad Catolica de Cordoba. 

Eduardo Borsini, Servicio de Neumonologia, Hospital Britanico de Buenos Aires

Medico especialista en Medicina Critica y Neumonologia. Diplomatura Universitaria en Medicina del Sueño. Staff de Neumonologia, area de Sueño y Ventilacion, Hospital Britanico de Buenos Aires. 

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Published

2021-06-28

How to Cite

1.
Camporro FA, Kevorkof GV, Gallmann A, Gazzoni F, Bulacio E, Gutierrez Magaldi I, Borsini E. Relation between inflammatory markers and severity of the apnea and hypopnea sleep syndrome. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 2021 Jun. 28 [cited 2024 Jul. 17];78(2):137-41. Available from: https://revistas.unc.edu.ar/index.php/med/article/view/30397

Issue

Vol. 78 No. 2 (2021)

Section

Original Papers

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