Microcephaly infant mortality in Brazil before zika outbreak
DOI:
https://doi.org/10.31053/1853.0605.v76.n4.25172Keywords:
Infant mortality, microcephaly, BrazilAbstract
Introduction
We present temporal and spatial variation of deaths from microcephaly in children under 1 year of age is analyzed at regional, state, and municipal level in the pre-Zika period in Brazil.
Materials and Methods
Data on births and deaths of infants with microcephaly was obtained from DATASUS from 1996 to 2013. Infant mortality rate from microcephaly (IMR-M) was estimated at Region, Federative Unit (UF), and Municipality level. Secular trend (ST) and risk of death variation were estimated using a Poisson regression model. Satscan software was used to obtain a statistic spatial scan for the Poisson model.
Results
IMR-M shows a non-significant negative ST in the Southeast, South and Central West Regions of Brazil. A greater IMR-M risk of death variation is found in the North and Northeast Regions. Most UFs in the Southeast, South and Central West Regions showed a negative ST, in contrast to what occurs in the UFs of the North and Northeast Regions showed a positive ST. Six high risk significant clusters were found: 3 in the North-Northeast and 3 in the South-SouthWest-Center-West.
Conclusions
The North and Northeast Regions showed positive ST for IRM-M and higher death risk, which was not observed in the other regions. Cluster distribution for higher IMR-M and risk resembles the distribution of the microcephaly and Zika cases in the outbreak period.
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References
Campos GS, Bandeira AC, Sardi SI. Zika Virus Outbreak, Bahia, Brazil. Emerg Infect Dis 2015; 21(10):1885–1886.
Portal da Saúde. Confirmação do Zika Vírus no Brasil. Ministerio da Saúde 2015. Available from: http://portalsaude.saude.gov.br/index.php/o-ministerio/principal/secretarias/svs/noticias-svs/17702-confirmacao-do-zika-virus-no-brasil.
WHO 2016. WHO statement on the first meeting of the International Health Regulations (2005) (IHR 2005) Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations. Feb 1, 2016. Available from: http://www.who.int/mediacentre/news/statements/2016/ .
Schuler-Faccini L, Ribeiro EM, Feitosa IM. Possible Association Between Zika Virus Infection and Microcephaly — Brazil, 2015. MMWR Morb Mortal Wkly Rep 2016; 65:59–62.
Portal da Saúde. Ministério da Saúde confirma relação entre vírus zika e casos de microcefalia. Ministerio da Saúde 2015. Available from: http://portalsaude.saude.gov.br/index.php/cidadao/principal/agencia-saude/21014-ministerio-da-saude-confirma-relacao-entre-virus-zika-e-microcefalia.
Schuler-Faccini L, Ribeiro EM, Feitosa IM, Horovitz DD, Cavalcanti DP, Pessoa A, Doriqui MJ, Neri JI, Neto JM, Wanderley HY, Cernach M, El-Husny AS, Pone MV, Serao CL, Sanseverino MT. Brazilian Medical Genetics Society–Zika Embryopathy Task Force Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015. Morb Mortal Wkly Rep 2016; 65(3):59-62.
Portal da Saúde 2016. Centro De Operações De Emergências Em Saúde Pública Sobre Microcefalias. Informe Epidemiológico Nº 33 – Semana Epidemiológica (Se) 26/2016 (26/06 A 02/07/2016) Monitoramento Dos Casos De Microcefalia No Brasil. Available from: http://portalsaude.saude.gov.br/images/pdf/2016/julho/08/Informe-Epidemiol--gico-n---33--SE-26-2016--05jul2016-22h30.pdf
Franca, G.V., Schuler-Faccini, L., Oliveira, W.K., Henriques, C.M., Carmo, E.H., Pedi, V.D., Nunes, M.L., Castro, M.C., Serruya, S., Silveira, M.F., Barros, F.C., Victora, C.G. Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet 2016;27;388 (10047):891-7
WHO 2016. Zika situation report. Zika and potential complications. Available from: http://www.who.int/emergencies/zika-virus/situation-report/who-zika-situation-report-12-02-2016.pdf?ua=1.
Rasmussen, S, Jamieson D, Honein M, Petersen L. Zika Virus and Birth Defects Reviewing the Evidence for Causality. N Engl J Med 2016; 374:1981-1987
Martines, R, Bhatnagar J, Keating M, et al. Notes from the field: evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses—Brazil, 2015. MMWR. Morbidity and mortality weekly report 2016; 65.
Calvet G, Aguiar RS, Melo AS, Sampaio SA, de Filippis I, Fabri A, Araujo ES, de Sequeira PC, de Mendonça MC, de Oliveira L, Tschoeke DA, Schrago CG, Thompson FL, Brasil P, Dos Santos FB, Nogueira RM, Tanuri A, de Filippis AM. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis 2016; S1473-3099(16)00095-5.
Soares de Araújo JS, Regis CT, Gomes RGS, et al. Microcephaly in northeast Brazil: a review of 16 208 births between 2012 and 2015. Bull World Health Organ E-pub 2016:
Barreto ML, Barral-Netto M, Stabeli R, Almeida-Filho N, Vasconcelos PF, Teixeira M, Buss P, Gadelha PE. Zika virus and microcephaly in Brazil: a scientific agenda. Lancet 2016; S0140-6736(16)00545-6.
Byass P, Wilder-Smith A utilising additional sources of information on microcephaly. Lancet 2016; S0140-6736(16)00519-5.
IBGE 2012. The Brazilian Institute of Geography and Statistics. Available from: http:// www.ibge.gov.br/home/mapa_site/mapa_site.php.
Kulldorff M, Huang L, Konty K. A scan statistic for continuous data based on the normal probability model. Int J Health Geogr 2009; 8:58.
COES Microcefalia 2016 (Centro de Operações de Emergências em Saúde Pública Sobre Microcefalias). Informe Epidemiológico Nº 41 – Semana Epidemiológica (SE) 34/2016 (21/08 a 27/08/2016). Monitoramento dos casos de microcefalia no Brasil. Ministerio de Saude do Brasil . Available from: www.saude.gov.br
ECLAMC 2016. DOCUMENTO ECLAMC FINAL. Resumo e conclusões dos Documentos 1-5. Bue, 30 de dezembro, 2015. Available from: http://www.eclamc.org/microcefaliaarchivos.php.
COES Microcefalia 2016 (Centro de Operações de Emergências em Saúde Pública Sobre Microcefalias). Informe Epidemiológico Nº 41 – Semana Epidemiológica (SE) 34/2016 (21/08 a 27/08/2016). Monitoramento dos casos de microcefalia no Brasil. Ministerio de Saude do Brasil . Available from: www.saude.gov.br
Boletim Epidemiológico. Secretaria de Vigilância em Saúde. Ministério da Saúde 2016; 47 (14).
COES Microcefalia 2017 (Centro de Operações de Emergências em Saúde Pública Sobre Microcefalias). Informe Epidemiológico Nº 47 – Semana Epidemiológica (SE) 52/2016 (25/12 a 31/12/2016). Monitoramento dos casos de microcefalia no Brasil. Ministerio de Saude do Brasil . Available from: www.saude.gov.br
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