Validity of the hypothesis in the Omics Era

Authors

  • Amado Alfredo Quintar Universidad Nacional de Córdoba. Facultad de Ciencias Médicas, Centro de Microscopía Electrónica. Córdoba, Argentina.

DOI:

https://doi.org/10.31053/1853.0605.v79.n4.39641

Keywords:

hypothesis-driven research, data-driven research, omics, theory

Abstract

.

Downloads

Download data is not yet available.

Author Biography

  • Amado Alfredo Quintar, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas, Centro de Microscopía Electrónica. Córdoba, Argentina.

    Universidad Nacional de Córdoba. Facultad de Ciencias Médicas, Centro de Microscopía Electrónica. Córdoba, Argentina.

    Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Investigaciones en Ciencias de la Salud (INICSA). Córdoba, Argentina.

    Director del Módulo Optativo: Introducción a la Investigación Científica en el Área Biomédica. Centro de Microscopía Electrónica. FCM.

References

1. Enderling H, Wolkenhauer O. Are all models wrong? Comput Syst Oncol. 2020 Dec;1(1):e1008. doi: 10.1002/cso2.1008.

2. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Deslattes Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X. The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51. doi: 10.1126/science.1058040. Erratum in: Science 2001 Jun 5;292(5523):1838.

3. Gout AM, Arunachalam S, Finkelstein DB, Zhang J. Data-driven approaches to advance research and clinical care for pediatric cancer. Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188571. doi: 10.1016/j.bbcan.2021.188571.

4. Emmert-Streib F. Severe testing with high-dimensional omics data for enhancing biomedical scientific discovery. NPJ Syst Biol Appl. 2022 Oct 21;8(1):40. doi: 10.1038/s41540-022-00251-8.

5. Anderson, C. The End of Theory: The Data Deluge Makes the Scientific Method Obsolete. Wired. 2008. Disponible en: https://www.wired.com/2008/06/pb-theory/

6. Defining the scientific method. Editorial. Nat Methods. 2009 Apr;6(4):237. doi: 10.1038/nmeth0409-237.

7. Pigliucci M. The end of theory in science? EMBO Rep. 2009 Jun;10(6):534. doi: 10.1038/embor.2009.111.

8. Kraus, W. L. (2015). "Editorial: Would You Like A Hypothesis With Those Data? Omics and the Age of Discovery Science." Mol Endocrinol 29(11): 1531-1534.

9. Mazzocchi F. Could Big Data be the end of theory in science? A few remarks on the epistemology of data-driven science. EMBO Rep. 2015 Oct;16(10):1250-5. doi: 10.15252/embr.201541001.

10. O'Malley MA, Elliott KC, Haufe C, Burian RM. Philosophies of funding. Cell. 2009 Aug 21;138(4):611-5. doi: 10.1016/j.cell.2009.08.008

11. Garrido Wainer JM, Hirmas-Montecinos N, Trujillo Osorio N. The policy of testing hypotheses in Chilean science. The role of a hypothesis-driven research funding programme in the installation of a hypothesis-driven experimental system in visual neuroscience. Stud Hist Philos Sci. 2022 Dec;96:68-76. doi: 10.1016/j.shpsa.2022.09.006.

Published

2022-12-21

Issue

Section

Editorial

How to Cite

1.
Validity of the hypothesis in the Omics Era. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 2022 Dec. 21 [cited 2024 Oct. 31];79(4):307-9. Available from: https://revistas.unc.edu.ar/index.php/med/article/view/39641

Similar Articles

401-410 of 1952

You may also start an advanced similarity search for this article.