Unión dermoepidermica: una barrera selectiva, compleja y vital
DOI:
https://doi.org/10.31053/1853.0605.v61.n1.32730Keywords:
.Abstract
Dernioepidermic junction ( DEJ ) is a highly coniplex region, containing a great variety of cellular elements. which clespite of having different embriogenesis, in teract with each other, generating different substances that keep the function and horneostasis of the greatest organ of the human body. DEJ is regarded as a highlv specialized basal lamina. which acts as a highly selective pathway for the migration of celis and macroniolecules, inducing cellular differentiation and micro envirornental metabolism modifications. DEJ may be divided into three zones regarding the basal lamina 1 -the nearest to epiderniic zone, having tonofilaments and hernidcsmosomes, which keep anchored basal cells. This region is limited by the lamina densa 2 -the intermecliate zonc, represented exelusively by lamina densa and finaily the lamina 3,-the third region - extencis from lamina densa to the upper dermis ant] extracelullar matrix. Despite there is much to learn about DEJ, the knowledgc about each molecule and function of every compartment vill enable us to know more about the pathogenesis of several dermatologic diseases, with a great prevalence in Wc clinical practice.
Downloads
References
Alberts 13., Bray 1)., Lewis 3., Raff M., Keithl R.. Watson J. Biologia Molecular de la Célula Editorial Omega Barcelona. 1983 Capitulos N'6.10.12.
Briggaman R.. Oalldor E, Wheler C. F'ormation and origin fo basal lamina and anchoring fibrils in adult human skin. J Cell Biol5l 1971, 384-390.
Bourlond A., Vanclooreri R.. Dcflorenne R la meinbrane basale sous- ép irle r ni i que: sa estructure and ulLracstructurc. Arch Bclg Dermatol Syphiligr 1966. 24: 119-123.
Brodv L. The inodified plasma inembrancs of the transition and horny cells in normal hunian epidermis as revealed by eleetron microscopy. Acta Dermalove. 49 1969.128-13
Brody L Aii eleetron microscopic study of the fibrillar clensity in the normal stratuui corncum. 3 liltraestruc Res. 1970 30: 209-212. Sornstc'iu P, Kuskin D., Balian G., Davidson J. Crouch E. Organization fo extracellular proteins on the connective tissuc ccli surface: rel evance [o ceil-matrix intcractions in vitro and ni vivo. Hyncs R. Structural relations betwcen fibroncectin and cytoplasnuc cytoskelctal. Aun. NY Acad Sri. 1998 312:93-105.
Eady RAJ., Babes, Blisters and basament rnembrane. F'rom sticky moiecules . Cli Exp Derrnatol .1988,12. 161-165.
Giluia N. Junctions betwen cells. In ccli communication. R,P Cox ecl. N. York wiley 1974. 1-29
Hynes R Structural ralationships 1)elween fibroenctin and cytoplasmic cyioskeletal nelworks, lo cytoskeletal Eleinents and plasma mcmbrane organizatiori O. Poste, Nicolson Eds. Vol 7, 1981, 100-137.
Hooper M., Subak J. Metabolic cooperalion betwcen cells. Int Rey Cytol 1981,69:45 KobayasiT., Dernioepidermal Junction of normal skin. J. Dcrrriatol 1978.5:157-161.
Murphy O.: Histolo of [he skin: Lever's Histopatholo' of the skin. Editor: David Elcier. First Eclition 1997-5-51
Rouslahti E., Engvail E.. Hayman E: Fihronectin and its relation to celtular structurc and hehavior. In Cdl Biolo' of Extracellular Matrix. N. York Plenum 1982 ED 1-lay, Ecl 295- 334
Sus¡ E., Belt W. Kelly 3: Fine structure of fibrillar complex associatecl with [lic basaniente menibrane in human oral mucosa. J. Cdl Biol. 1997. 34:686-690
Yancey KB: Adhcsion niolecules: 11 Interaci ion of keratinocv[cs witli epidemial basamerit membrane. ['ros. Derinatol 1995,104:1008-1012.
Downloads
Published
Issue
Section
License
Copyright (c) 2021 Universidad Nacional de Córdoba
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The generation of derivative works is allowed as long as it is not done for commercial purposes. The original work may not be used for commercial purposes.
How to Cite
