Enfermedad del coronavirus (covid-19) y las sirtuinas

Autores/as

  • Ronald Eleazar Huarachi Olivera Laboratorio de Biotecnologia Celular y Molecular Avanzada, Universidad Nacional de San Agustìn https://orcid.org/0000-0002-3504-3399
  • Antonio Lazarte Rivera Laboratorio de Biotecnología Celular y Molecular Avanzada (LAB-BIOTCEMA), Universidad Nacional de San Agustìn, Arequipa Perù https://orcid.org/0000-0002-9333-0505

DOI:

https://doi.org/10.31053/1853.0605.v77.n2.28196

Palabras clave:

Infecciones por coronavirus, neoplasias, Inhibidores de Histona, Desacetilasas, NAD, Sirtuinas

Resumen

Las  proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19.

Fuente y selección de datos: Para ello se realizó una búsqueda en Medline, Scopus y WOS, donde se incluyeron estudios descriptivos de cada una de las funciones de las sirtuinas ajustado a las recientes investigaciones científicas. La inhibición de SIRT1 disminuye la citotoxicidad de las células T CD8 en pacientes con lupus eritematoso sistémico, siendo susceptibles a infecciones por SARS CoV-2. La SIRT2 se regula por la secreción de IL-4 por los eosinófilos y el aumento de SIRT2 incrementa la hiperplasia, en contraste la SIRT3 promueve la angiogénesis, induciendo la remodelación cardiaca. La SIRT4 es un supresor de tumores, en contraste con la SIRT5 que promueve la proliferación celular provocando el cáncer colorrectal; la SIRT6 atenúa al herpes virus asociado al Sarcoma de Kaposi (KSHV) en pacientes inmuno comprometidos. La supresión de SIRT7 inhibe el crecimiento de las células cancerígenas endometriales.

Conclusiones: Se concluye que las SIRT1, SIRT2 y SIRT4 están involucradas en el desarrollo del cáncer, la supresión de SIRT5 y SIRT7 promueve la apoptosis de células cancerígenas y la SIRT6 atenúa la replicación de KSHV, además la vía de patología molecular de la COVID-19 está asociada a la inhibición de la actividad de SIRT1 que puede estar relacionada a procesos inflamatorios.

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Biografía del autor/a

Ronald Eleazar Huarachi Olivera, Laboratorio de Biotecnologia Celular y Molecular Avanzada, Universidad Nacional de San Agustìn

Autor principal del articulo de revision, Magister en Biotecnologia y estudiante del Doctorado en Ciencias Biologicas mencion Biologìa Celular y Molecular de la Facultad de Ciencias Biològicas de la Universidad de Antofagasta de Chile

Antonio Lazarte Rivera, Laboratorio de Biotecnología Celular y Molecular Avanzada (LAB-BIOTCEMA), Universidad Nacional de San Agustìn, Arequipa Perù

Profesor de la Facultad de Ciencias Biologicas de la Universidad Nacional de San Agustin de Arequipa, Responsable de LAB-BIOTCEMA

Citas

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Publicado

2020-06-16

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1.
Huarachi Olivera RE, Lazarte Rivera A. Enfermedad del coronavirus (covid-19) y las sirtuinas. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 16 de junio de 2020 [citado 28 de marzo de 2024];77(2):117-25. Disponible en: https://revistas.unc.edu.ar/index.php/med/article/view/28196

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