Monodosis de FLEROXACINA para el tratamiento de la diarrea aguda estival en el adulto
DOI:
https://doi.org/10.31053/1853.0605.v55.n1.40385Keywords:
acute diarrhea, adult patients, clinical trial, treatment, quinolones, fleroxacinAbstract
Ihe purpose of this worL was lo evaluate Ihe ef113cacv and safi2tv ofa single dose of400 mgofllcroxacin foithe enlpiric antibiotic treat- inent oí' acote diarrhea in adu It patients. A prospective. double-blincl, placebo-control led, randomizcd trial vas designed. Al! the adult patients vho consu llecl iii our hospital br acute d iarrhea from December 1994 lo Apri 1 1995 were included. 72 patients were random- ized ni receive a single dose of 11eroxacin400 me and 73 were placebo. 1b rt -eight patients in each group were evaluable for efbcac) Bet\een both groups there were nol siatistical l sigtflcant dil'ferences in age, sex, number oí' ]ose stoo!s pci' clav at inclusion. davs since lile onset of svnlptoms op tu inclusion, other svnlpronis than ciiarrhea lit inclusion, percent- ages of bacterial pathogens and parasites sn- atecl aoci svniplonlatic treatnient indicatecl. At ihe thircl da) since inclusion. clinical cure oc- corred in 72.2% of lile patients receiving tieroxacin. comparecl Nviili 36.4% ofthose ie- ceivinc,p!aceho: p-0.002. Tilo niean±SD time tu cure was 2.2- 1 .2 davs iii the llel'oxacm gi'otip and13 .2—.() cla\s iii the placebo group: p=O.O 1 lwent\ -e¡(—,lit and 16.7% of patients reporteci aciverse et'6cts in lhc ileroxacin aoci placebo
eroups respectiveiv: p=0.3. ¡lis concbuded that a singlecloscof lleroxacin 400 mg san effective and sale alternative for the entpiric antibiotic treatineni ob acote diarrhea o adults.
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