Patología de la placenta de rata inducida por la deficiencia de ácidos grasos
DOI:
https://doi.org/10.31053/1853.0605.v59.n2.38489Keywords:
Rats placenta, Metrial gland, Labyrinthum, Fatty acids, a-Iinoleic acidAbstract
Lipids are important ceil components, both from the structural and the functional point of view. Besides they intervein in transporting
functions, cell recognition and immunity. Essential Fatty Acids (EFA) are important for the functional and structural maintenance of
animal organisms. In our laboratory, it was demonstrated that one group of pregnant rats fed on an EFA deficient diet, and other group of rats fed onthe same diet but with 5% of corn oil (rich in linoleic acid) showed alterations on the development of the metrial gland. In the present work, 57 female rats of a Wistar strain were fed since weaning with one of the followingdiets : EFAD :deficient in essential fatty acids, COD: EFAD + 5% corn oil (linoleic acid sufficient but (x- linoleic acid deficient); SAD: EFAD + 5% soy oil (both EFA sufficient
) and CD: commercial diet. After 3 months theanimals were sacrificed on the 13 th. day ofgestation.Uteru's horns were dissected and the irnplantation sities were fixed on formo] and embebbed in parafine. The observations were carried out with RÍE coloured cross-sections
and the corialantoidea placenta, the sities of implanctations and the sitios of reabsortions were studied. The metrial gland of DAGE and
DAM rats presented structural modifications compared to DC rats. The most relevant findings were: indifferentiation of thegranulated metrial gland celis and an increase in the amount of connective tissue.
188 GLOCKER T. M.
In DAS rats, on the contrary, the aspect
of the metrial gland was similar to the observed
in the DC group. In the DAGE and the DAM
groups Labyrinthum was enlarged with
vascular septum group . Mean while DAS was
similar to group DC (thin and vascular).
Differences in the sities of implanctations and
reabsortions were not detected. The present
results suggest that a- linolenico acid is
essential for the rat placenta to reach normal
development.
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