Hepatitis associated aplastic anemia during SARS-CoV-2 pandemic
DOI:
https://doi.org/10.31053/1853.0605.v79.n2.35138Keywords:
anemia, aplastic, hepatitis, coronavirus infectionsAbstract
The hepatitis-associated aplastic anemia is one of the acquired bone marrow failure syndromes. It is a stereotyped form of presentation of aplastic anemia and accounts for 2 - 5 % of the cases in the West. Its treatment, which does not differ from that of aplastic anemia, consists of immunosuppression when bone marrow transplant is not possible. Nonetheless, during the SARS-CoV-2 pandemic, recommendations restricting the use of antithymocyte globulin to those cases with the highest risk of death have been issued, since the prognosis of CoViD-19 tends to be worse if administered. We present an otherwise-healthy 18-year-old male who was diagnosed with a hepatitis-associated aplastic anemia and received a personalized treatment following these recommendations.
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References
Brown, KE, TisdaleJ, Barrett AJ, DunbarCE,Young NS.Hepatitis-associated aplastic anemia. N Engl J Med. 1997; 336:1059–64. Doi:10.1056/NEJM199704103361504
European Society for Blood and Marrow Transplantation. COVID-19 - Bone Marrow Failure and PNH Recommendations On behalf of the Severe Aplastic Anemia Working Party, European Group for Blood and Marrow Transplantation (EBMT); Disponible en: https://www.ebmt.org/sites/default/files/2020-03/SAAWP_COVID_Recommendations.pdf.
Cook JR. Bone Marrow Failure Syndromes. In: His ED, Goldblum JR. Hematopathology: A Volume in the Series: Foundations in Diagnostic Pathology. Philadelphia: Elsevier; 2018.p. 167-83.
Sociedad Argentina de Hematología. Brodsky A, Elena G, Milovic V, Ramos A, Rossi BM, Watman N. Síndromes de fallomedular; Disponible en:http://www.sah.org.ar/docs/2019/Sindromes_de_Fallo_Medular.pdf
Young NS. Aplastic Anemia. N Engl J Med 2018; 379:1643-56.
Fattizzo B, Ireland R, Dunlop A, et al. Clinical and prognostic significance of small paroxysmal nocturnal hemoglobinuria clones in myelodysplastic syndrome and aplastic anemia. Leukemia. 2021. Epub2021 Mar 4. Doi:10.1038/s41375-021-01190-9
Rho H, Wells RA. A game of clones: The complex interplay of aplastic anaemia, myelodysplastic syndrome, and paroxysmal nocturnal haemoglobinuria. EMJ 2018; 3:108-15.
Grupo Español de Trasplante Hematopoyético y Terapia Celular. Guía para el diagnóstico y tratamiento de las Insuficiencias Medulares; DIsponible en: https://www.sehh.es/servicios-para-los-socios/445-documentos/guias/123286-guia-para-el-diagnostico-y-tratamiento-de-las-insuficiencias-medulares.
Lorenz E, Quaiser K. Panmyelophatienach hepatitis epidemica. Wien Med Wochenschr 1955; 105:19-22.
Locasciulli A, Bacigalupo A, Bruno B, et al. Hepatitis-associated aplastic anaemia: epidemiology and treatment results obtained in Europe. A report of The EBMT aplastic anaemia working party. Br J Haematol 2010; 149:890-5.
Zylberman M, Turdó K, Odzak A, Arcondo F, Altabert N, Munné S. Anemia aplásica asociada a hepatitis E. Informe de un caso [Hepatitis E virus-associatedaplastic anemia. Reportof a case]. Medicina (B Aires) 2015; 75:175-7.
DeZern AE, Churpek JE. Approach to the diagnosis of aplastic anemia. BloodAdv 2021; 22:2660-71.
Vallejo Llamas JC. Management of aplastic anemia during the phase of defervescence of the COVID-19 pandemic. Abordaje de la aplasia medular en la fase de defervescencia de la pandemia por COVID-19. Med Clin (Barc) 2021; 157:89-90.
Gatselis NK, Zachou K, Koukoulis GK, Dalekos GN. Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics. World J Gastroenterol. 2015;21:60-83. doi:10.3748/wjg.v21.i1.60
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