Osmophobia and vestibular migraine

a narrative review about their frequency and clinical outcomes

Authors

  • Alejandro Garcia Médico, Postdoctoral Fellow, Departamento de Otorrinolaringología, Eaton Peabody Laboratories. Massachusetts Eye and Ear Infirmary. https://orcid.org/0000-0002-8204-8053
  • Sebastian Rivera Retamal Fonoaudiólogo, Magister en Audiología. Docente Universitario. Escuela de Fonoaudiología, Universidad Santo Tomás. https://orcid.org/0000-0003-1823-0229
  • Bernardita Alvear Fonoaudióloga, Magister en Docencia Universitaria. Académica Universidad de Chile. https://orcid.org/0000-0002-5340-4266
  • Melissa Castillo-Bustamante Otorrinolaringóloga, Postdoctoral Fellow, Departamento de Otorrinolaringología, Eaton Peabody Laboratories Massachusetts Eye and Ear Infirmary.

DOI:

https://doi.org/10.31053/1853.0605.v79.n1.33699

Keywords:

vertigo, migraine disorders, olfaction disorders

Abstract

Aim: Vestibular migraine is one of the most common vestibular disorders, which includes headache, photophobia, phonopobia and visual auras. Others as osmophobia are common but usually subregistered, and potentially would be involved in the vestibular migraine episodes. The aim of this study was to perform a search about the frequency and clinical interaction between vestibular migraine and osmophobia.

Data search: A literature review search was conducted on PubMed, EBSCO, Scielo, Google Scholar and  Bvsalud of published studies between  2011  and 2021  using the MeSH terms  ‘vertigo and olfaction disorders’, ‘dizziness and olfaction disorders’, ‘migraine disorders and olfaction disorders’.

Study selection: 12 articles were found, where patients with diagnosis of vestibular migraine according to Barany Society, reported clinical symptoms and the prevalence of each symptom related was documented. Only two studies, presented relevant information about osmophobia and vestibular migraine.

Data extraction and results: From 277 individuals diagnosed with vestibular migraine in two observational studies, only 5%-12%, reported osmophobia. To date only one case report describe in extension the relationship between vestibular migraine and osmophobia.

Conclusions: This symptom would be underdiagnosed and subregistered in individuals with vestibular migraine. Further studies are needed to determine this association.

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Author Biographies

Alejandro Garcia, Médico, Postdoctoral Fellow, Departamento de Otorrinolaringología, Eaton Peabody Laboratories. Massachusetts Eye and Ear Infirmary.

Médico, Postdoctoral Fellow, Departamento de Otorrinolaringología, Eaton Peabody Laboratories Massachusetts Eye and Ear Infirmary. Boston, Estados Unidos

Sebastian Rivera Retamal, Fonoaudiólogo, Magister en Audiología. Docente Universitario. Escuela de Fonoaudiología, Universidad Santo Tomás.

Fonoaudiólogo, Magister en Audiología. Docente Universitario. Escuela de Fonoaudiología, Universidad Santo Tomás. Viña del Mar, Chile

Bernardita Alvear, Fonoaudióloga, Magister en Docencia Universitaria. Académica Universidad de Chile.

Fonoaudióloga, Magister en Docencia Universitaria. Académica Universidad de Chile. Santiago, Chile

Melissa Castillo-Bustamante, Otorrinolaringóloga, Postdoctoral Fellow, Departamento de Otorrinolaringología, Eaton Peabody Laboratories Massachusetts Eye and Ear Infirmary.

Otorrinolaringóloga, Postdoctoral Fellow, Departamento de Otorrinolaringología, Eaton Peabody Laboratories Massachusetts Eye and Ear Infirmary. Boston, Estados Unidos.

References

Cho SJ, Kim BK, Kim BS, Kim JM, Kim SK, Moon HS, Song TJ, Cha MJ, Park KY, Sohn JH. Vestibular migraine in multicenter neurology clinics according to the appendix criteria in the third beta edition of the International Classification of Headache Disorders. Cephalalgia. 2016 Apr;36(5):454-62. doi: 10.1177/0333102415597890.

Lempert T, Neuhauser H. Epidemiology of vertigo, migraine and vestibular migraine. J Neurol. 2009 Mar;256(3):333-8. doi: 10.1007/s00415-009-0149-2.

Neuhauser HK, Lempert T. Vertigo: epidemiologic aspects. Semin Neurol. 2009 Nov;29(5):473-81. doi: 10.1055/s-0029-1241043.

Paz-Tamayo A, Perez-Carpena P, Lopez-Escamez JA. Systematic Review of Prevalence Studies and Familial Aggregation in Vestibular Migraine. Front Genet. 2020 Aug 31;11:954. doi: 10.3389/fgene.2020.00954.

Formeister EJ, Rizk HG, Kohn MA, Sharon JD. The Epidemiology of Vestibular Migraine: A Population-based Survey Study. Otol Neurotol. 2018 Sep;39(8):1037-1044. doi: 10.1097/MAO.0000000000001900.

Lempert T, Olesen J, Furman J, Waterston J, Seemungal B, Carey J, Bisdorff A, Versino M, Evers S, Newman-Toker D. Vestibular migraine: diagnostic criteria. J Vestib Res. 2012;22(4):167-72. doi: 10.3233/VES-2012-0453.

Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia. 2004;24 Suppl 1:9-160. doi: 10.1111/j.1468-2982.2003.00824.x.

Radtke A, von Brevern M, Neuhauser H, Hottenrott T, Lempert T. Vestibular migraine: long-term follow-up of clinical symptoms and vestibulo-cochlear findings. Neurology. 2012 Oct 9;79(15):1607-14. doi: 10.1212/WNL.0b013e31826e264f.

Beh SC, Masrour S, Smith SV, Friedman DI. The Spectrum of Vestibular Migraine: Clinical Features, Triggers, and Examination Findings. Headache. 2019 May;59(5):727-740. doi: 10.1111/head.13484.

Teggi R, Colombo B, Albera R, Asprella Libonati G, Balzanelli C, Batuecas Caletrio A, Casani A, Espinoza-Sanchez JM, Gamba P, Lopez-Escamez JA, Lucisano S, Mandalà M, Neri G, Nuti D, Pecci R, Russo A, Martin-Sanz E, Sanz R, Tedeschi G, Torelli P, Vannucchi P, Comi G, Bussi M. Clinical Features, Familial History, and Migraine Precursors in Patients With Definite Vestibular Migraine: The VM-Phenotypes Projects. Headache. 2018 Apr;58(4):534-544. doi: 10.1111/head.13240.

Huang TC, Wang SJ, Kheradmand A. Vestibular migraine: An update on current understanding and future directions. Cephalalgia. 2020 Jan;40(1):107-121. doi: 10.1177/0333102419869317.

Andress-Rothrock D, King W, Rothrock J. An analysis of migraine triggers in a clinic-based population. Headache. 2010 Sep;50(8):1366-70. doi: 10.1111/j.1526-4610.2010.01753.x.

Yan M, Guo X, Liu W, Lu J, Wang J, Hu L, Xia K, Ni J, Lu H, Zhao H. Temporal Patterns of Vertigo and Migraine in Vestibular Migraine. Front Neurosci. 2020 Apr 15;14:341. doi: 10.3389/fnins.2020.00341.

Wattiez AS, O'Shea SA, Ten Eyck P, Sowers LP, Recober A, Russo AF, Fattal D. Patients With Vestibular Migraine are More Likely to Have Occipital Headaches than those With Migraine Without Vestibular Symptoms. Headache. 2020 Sep;60(8):1581-1591. doi: 10.1111/head.13898.

Van Ombergen A, Van Rompaey V, Van de Heyning P, Wuyts F. Vestibular migraine in an otolaryngology clinic: prevalence, associated symptoms, and prophylactic medication effectiveness. Otol Neurotol. 2015 Jan;36(1):133-8. doi: 10.1097/MAO.0000000000000596.

Radtke A, Neuhauser H, von Brevern M, Hottenrott T, Lempert T. Vestibular migraine--validity of clinical diagnostic criteria. Cephalalgia. 2011 Jun;31(8):906-13. doi: 10.1177/0333102411405228.

Power L, Shute W, McOwan B, Murray K, Szmulewicz D. Clinical characteristics and treatment choice in vestibular migraine. J Clin Neurosci. 2018 Jun;52:50-53. doi: 10.1016/j.jocn.2018.02.020.

Morganti LO, Salmito MC, Duarte JA, Bezerra KC, Simões JC, Ganança FF. Vestibular migraine: clinical and epidemiological aspects. Braz J Otorhinolaryngol. 2016 Jul-Aug;82(4):397-402. doi: 10.1016/j.bjorl.2015.06.003.

Neff BA, Staab JP, Eggers SD, Carlson ML, Schmitt WR, Van Abel KM, Worthington DK, Beatty CW, Driscoll CL, Shepard NT. Auditory and vestibular symptoms and chronic subjective dizziness in patients with Ménière's disease, vestibular migraine, and Ménière's disease with concomitant vestibular migraine. Otol Neurotol. 2012 Sep;33(7):1235-44. doi: 10.1097/MAO.0b013e31825d644a.

Abouzari M, Goshtasbi K, Moshtaghi O, Tan D, Lin HW, Djalilian HR. Association Between Vestibular Migraine and Migraine Headache: Yet to Explore. Otol Neurotol. 2020 Mar;41(3):392-396. doi: 10.1097/MAO.0000000000002528.

Shankar Kikkeri N, Nagalli S. Migraine with Aura. 2021 Nov 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–.

Vingen JV, Pareja JA, Støren O, White LR, Stovner LJ. Phonophobia in migraine. Cephalalgia. 1998 Jun;18(5):243-9. doi: 10.1046/j.1468-2982.1998.1805243.x.

Vingen JV, Pareja JA, Stovner LJ. Quantitative evaluation of photophobia and phonophobia in cluster headache. Cephalalgia. 1998 Jun;18(5):250-6. doi: 10.1046/j.1468-2982.1998.1805250.x.

Silva-Néto RP, Soares AA. Osmophobia and odour-triggered headaches: review of the literature and main research centres. Eur Neurol Rev. 2017 May;12(1):24-7. doi: 10.17925/ENR.2017.12.01.24.

Agessi LM, Villa TR. Vestibular Migraine with Visual Aura and Olfactory Hallucination in Children: Two Case Reports. Neuropediatrics. 2018 Dec;49(6):414-416. doi: 10.1055/s-0038-1673642.

Murdin L, Davies RA, Bronstein AM. Vertigo as a migraine trigger. Neurology. 2009 Aug 25;73(8):638-42. doi: 10.1212/WNL.0b013e3181b38a04.

Rocha-Filho PA, Marques KS, Torres RC, Leal KN. Osmophobia and Headaches in Primary Care: Prevalence, Associated Factors, and Importance in Diagnosing Migraine. Headache. 2015 Jun;55(6):840-5. doi: 10.1111/head.12577.

Demarquay G, Royet JP, Mick G, Ryvlin P. Olfactory hypersensitivity in migraineurs: a H(2)(15)O-PET study. Cephalalgia. 2008 Oct;28(10):1069-80. doi: 10.1111/j.1468-2982.2008.01672.x.

Stankewitz A, May A. Increased limbic and brainstem activity during migraine attacks following olfactory stimulation. Neurology. 2011 Aug 2;77(5):476-82. doi: 10.1212/WNL.0b013e318227e4a8.

Anderson AK, Christoff K, Stappen I, Panitz D, Ghahremani DG, Glover G, Gabrieli JD, Sobel N. Dissociated neural representations of intensity and valence in human olfaction. Nat Neurosci. 2003 Feb;6(2):196-202. doi: 10.1038/nn1001.

Weiller C, May A, Limmroth V, Jüptner M, Kaube H, Schayck RV, Coenen HH, Diener HC. Brain stem activation in spontaneous human migraine attacks. Nat Med. 1995 Jul;1(7):658-60. doi: 10.1038/nm0795-658.

Henkin RI, Potolicchio SJ, Levy LM. Olfactory Hallucinations without Clinical Motor Activity: A Comparison of Unirhinal with Birhinal Phantosmia. Brain Sci. 2013 Nov 15;3(4):1483-553. doi: 10.3390/brainsci3041483.

Obermann M, Wurthmann S, Steinberg BS, Theysohn N, Diener HC, Naegel S. Central vestibular system modulation in vestibular migraine. Cephalalgia. 2014 Nov;34(13):1053-61. doi: 10.1177/0333102414527650.

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Published

2022-03-07

How to Cite

1.
Garcia A, Rivera Retamal S, Alvear B, Castillo-Bustamante M. Osmophobia and vestibular migraine: a narrative review about their frequency and clinical outcomes. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 2022 Mar. 7 [cited 2024 Jul. 17];79(1):43-7. Available from: https://revistas.unc.edu.ar/index.php/med/article/view/33699

Issue

Vol. 79 No. 1 (2022)

Section

Literature Reviews

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