Treatment of hypertension in type 2 diabetes: Importance of therapeutic selection
DOI:
https://doi.org/10.31053/1853.0605.v62.n3.32473Keywords:
hypertension, type 2 diabetes, therapeutic selectionAbstract
BACKGROUND: Type 2 diabetes and essential hypertension are the iiiost comrnon causes of end-stage renal disease in Argentina. Over 887 organ transplaritations performed ni the year 2004. 577 were kidney transplants. la urban and rural populations hypertensioii was more preva]ent in type 2 diabetics, in particular systolic hypertension. Outcome studies are useci tú tneasure clinically meariingtul prin-iary end points, such as mortality and cardiovascular inorbidity. Our current knowledge of the effects of antihypertensive agents on cardiovascular risk la hypertensive patients with type 2 diabetes has heen achieveci froni subgroups inclucled in large. scale sluclies. SCOPE: The present study, basen on a search of MEDLINE literature in the period 1990-2005, revised major ranclomisecl studies with the purpose of finding out vhich are the most advisable therapeutic strdtegies agoinst this morbid association. The majol 1 y of parients redluire 2 tú 4 antihypertensive medications lo achive BP levels thai coi relate with diminished progiession of target oigan damages. Despite the advantages of renin angiotensin system inhibitors the initial chotee of merlicatiuns should be based oii Wc eviclences of target oigan damages. la those patieiits without any evidence of eomplieations, the pi imary goal seems tú he achieving their BP tú -- 130/80 mm Ng beyond the cliffercnces ainong antihypertensive drugs classe;. wltile ¡u those with target orgari damage evidences maintain BP <120/75 mm Hg
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