Molecular aspects of antineoplasic action of vitamin D
Keywords:
cancer, calcitriol, molecular mechanisms, antineoplasic effectsAbstract
The effects of the environment, particularly dietary factors, may influence in the development and prevention of cancer. Vitamin D (colecalciferol) has been associated for years with calcium homeostasis regulation, but many epidemiological, biochemical and genetic studies reveal non classic effects of vitamin D, such as vitamin D involvement in the progression of different types of cancer. The aim of the present article was to give a review about the molecular mechanisms of the antineoplasic action of vitamin D. These effects are still not completely established, but it is well known that vitamin D induces cellular arrest, triggers apoptotic pathways, inhibits angiogenesis and alters cellular adhesion. To maintain suitable vitamin D levels seems to be necessary for many physiological processes, and not only for bone homeostasis. Clinical studies might determine vitamin D levels that can also protect against the cancer development
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References
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Garland, CF, Gorham, ED, Mohr, SB, Grant, WB, Giovannucci, EL, Lipkin, M, Newmark, H, Holick, MF, Garland, FC.: Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol; 2007, 103: 708-711.
Murillo, G, Matusiak, D, Benya, RV, Mehta, RG: Chemopreventive efficacy of 25-hydroxyvitamin D3 in colon cancer. J Steroid Biochem Mol Biol;
Lin, R, White, JH: The pleitropic actions of vitamin D. Bio Essays; 2003, 26: 21-28. 3.
Bickle, D: Nonclassic actions of vitamin D. J Clin Endocrinol Metab; 2009, 94: 26-34. 4.
De Luca, HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr; 2004, 74: 494-500.
Ali, MM, Vaidya, V: Vitamin D and cancer. J Cancer Res Ther; 2007, 3: 225-230.
Feskanich, D, Ma, J, Fuchs, CS, Kirkner, GJ, Hankinson, SE, Hollis, BW, Giovannucci, EL: Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev; 2004, 13: 1502-1508.
Abbas, S, Chang-Claude, J, Linseisen, J: Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study. Int J Cancer; 2009,124: 250-255.
Blackmore, KM, Lesosky, M, Barnett, H, Raboud, JM, Vieth, R, Knight, JA: Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer. Am J Epidemiol; 2008,168: 915-924.
Garland, CF, Mohr, SB, Gorham, ED, Grant, WB, Garland, FC: Role of ultraviolet B irradiance and vitamin D in prevention of ovarian cancer. Am J Prev Med; 2006, 31: 512-514.
Bouillon, R, Eelen, G, Verlinden, L, Mathieu, C, Carmeliet, G, Verstuyf, A: Vitamin D and cancer. J Steroid Biochem Mol Biol; 2006, 102: 156-162.
Bikle, D: What is new in vitamin D: 2006-2007. Curr Opin Rheumatol; 2007, 19: 383-388.
Demay, MB: Mechanisms of vitamin D receptor action. Ann NY Acad Sci; 2006, 1068: 204-213.
Ingraham, BA, Bragdon, B, Nohe, A: Molecular basis of the potential of vitamin D to prevent cancer. Curr Med Res Opin; 2008, 24: 139-149. -20- 14.
Welsh, J: Targets of vitamin D receptor signaling in the mammary gland. J Bone Min Res; 2007, 22: 86-89.
Johnson, CS, Muindi, JR, Hershberger, PA, Trump, DL: The antitumor efficacy of calcitriol: preclinical studies. Anticancer Res; 2006, 26: 2543-2549.
Maruyama, R, Aoki, F, Toyota, M, Sasaki, Y, Akashi, H, Mita, H, Suzuki, H, Akino, K, Ohe-Toyota, M, Maruyama, Y, Tatsumi, H, Imai, K, Shinomura, Y, Tokino T: Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation. Cancer Res; 2006, 66: 4574-4583.
Welsh, J:Vitamin D and breast cancer: insights from animal models. American Journal of Clinical Nutrition; 2004, 80: 1721S-1724S.
Marchionatti, AM, Picotto, G, Narváez, CJ, Welsh, J, Tolosa de Talamoni, N: Antiproliferative action of menadione and 1,25(OH)2D3 on breast cancer cells. J Steroid Mol Biol; 2009, 113: 227-232.
Palmer, HG, Gonzalez-Sancho, JM, Espada, J, Berciano, MT, Puig, I, Baulida, J, Quintanilla, M, Cano, A, de Herreros, AG, Lafarga, M, Muñoz, A.: Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol; 2001, 154: 369-387.
Campbell, MJ, Gombart, AF, Kwok, SH, Park, S, Koeffler, HP: The antiproliferative effects of 1,alpha- 25(OH)2D3 on breast and cancer cells are associated with induction of BCRA1 gene expression. Oncogene; 2000, 19: 5091-5097. .
Shah, S, Islam, MN, Dakshanumurthy, S, Rizvi, I, Rao, M, Herrell, R, Zinser, G, Valrance, M, Aranda, A, Moras, D, Norman, A, Welsh, J, Byers, S,W: The molecular basis of vitamin D receptor and beta-catenin cross regulation. Mol Cell; 2006, 281: 39114-39120.
Dhawan, P, Wieder, R, Christakos, S: CCAAT enhancer-binding protein alpha is a molecular target for 1,25-dihydroxyvitamin D3 in MCF-7 breast cancer cells. J Biol Chem; 2009, 284: 3086-3095. 23.
Yin, J, Pollock, C, Tracy, K, Chock, M, Martin, P, Oberst, M, Kelly, K: Activation of the RalGEF/Rak pathway promotes prostate cancer metastasis to bone. Mol Cell Biol; 2007, 27: 7538-7550.
Freake, HC, Abeyasekera, G, Iwasaki, J, Marcocci, C, MacIntyre, I, McClelland, RA, Skilton, RA, Easton, DF, Coombes, RC. Measurement of 1,25-dihydroxyvitamin D3 receptors in breast cancer and their relationship to biochemical and clinical indices. Cancer Res; 1984, 44: 1677-1681.
Schwartz, G: Prostate cancer, serum parathyroid hormone, and the progression of skeletal metastases. Cancer Epidemiol Biomarkers Prev; 2008, 17: 478-483.
Schöndorf, T, Eisberg, C, Wassmer, G, Warm, M, Becker, M, Rein, DT, Göhring, UJ: Association of the vitamin D receptor genotype with bone metastases in breast cancer patients. Oncology; 2003, 64: 154-159.
Garland, CF, Gorham, ED, Mohr, SB, Grant, WB, Giovannucci, EL, Lipkin, M, Newmark, H, Holick, MF, Garland, FC.: Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol; 2007, 103: 708-711.
Murillo, G, Matusiak, D, Benya, RV, Mehta, RG: Chemopreventive efficacy of 25-hydroxyvitamin D3 in colon cancer. J Steroid Biochem Mol Biol;
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Published
2020-02-14
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1.
Bohl LP, Liaudat AC, Picotto G, Tolosa de Talamoni NG. Molecular aspects of antineoplasic action of vitamin D. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 2020 Feb. 14 [cited 2024 Aug. 16];65(1):16-21. Available from: https://revistas.unc.edu.ar/index.php/med/article/view/27686
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