Hyperhomocysteine like risk factor in patient with systemic lupus erythematous with antiphospholipid sindrom

Abstract

Objectives: to detect the prevalence of hyperhcy lo SLE patients with and without antiphospholipid syndrom; to compare the Hcy levels between those patients and healthy  controis and to determine the correlation between hyperhcy and antiphospholipid  antibodies.

Patients and methods: we studied 44 SLE patients: 17 had antiphospholipid syndrom and  27 didn't have it, and we compared them to 24 hcalthy controls. All of them where checked  clinically and with laboratory tests like anticardiolypin antibodies, lupus anticoagulant and  Hcy. Hcy> 9 was considered abnormal. Patient who had hyperhcy were treated with folie acid+vitB6+vitBl2 a nionth along.  Statistical analysis: cualytative variables: chi square or  Fischer's; cuantitative variables: Student's T test or Mann- Whitney's test.

Results and conclutions: there were 35 tromhotic manifestations in 44 patients. Hyperhcy  was present in 27 SLE patients (61,4%), 12 of them had antiphospholipid syndrom. Hcy  concentrations patients vs.controls was statisticaly different (p=0,002). There was also  stastisticaly different the bey concentration from SLE patients with SAF vs controis  (p=0,003) and without SAF vs controis (p= 0.0 15). From 33 SLE patients, 20 (33%) were aCL(+). 15(75%) of them had hiperhcy