Anphibian model study for evolutionary respiratory control.
Abstract
Recent perinal advances have made possible that premature newborns survive increasingtly in earlier developmental stages. This babies requires sophisticated and costly critical intensive care to address the problems associated with inrnadurity of the respiratory system. In addition respiratory instability and apnea reflecting inmaturity of the respiratory control system are majar causes of morbidity and prolonged hospitalization in this highly vulnerable group of paticnts. These concerns have contributed to the development of research in respiratoy evolutionary neurobiology. While the majority of researchers working in this fieid use rodents as an animal model, recent research using in ultra brainstem preparations from bullfrog (Rana catesbetana) have reveled the technical advantages of this model to study the basic principles underlying respiratory control and its ontogeny between vertebrates. The present article review the recent advances in the area of research with special interest on episodic breathing and the role of serotoninergic and GABAergic modulation of respiratory control during development..
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Jansen AH, CherriickV. Foetal breathing and development of control of breathing. JAppl Physiol 991:70:1431-46.
Mortola JP. Respiratory physiology of newborns marnrnals: a comparative perspective. Baltimore: The Jhon Hopkins University Press, 2001:344 p.
Adrian ED, Buytendik FJJ. Potencial changes in the isolated brain stem of the goldfish. JPhysiot(Lond) 1931:71:121-35.
Suzue T. Respiratory rhythm generation in the in vitro bain stem-spinal cord preparation
Of neonatal rat. JPhysiol(Lond) 1984:354:173-83.
Cuestas E, Cáceres A, Palacio S. Modelos animales de lesión y reparación del cerebro en desarrollo. Medicina (Buenos Aires) 2007: 67:177-182.
Smith JC, Ellenberger HH, Ballanyi K, et al. Pre-Bótzinger complex: A brainstem region that may generate respiratory rhythn in marnmals. Science 1991:254:173-183.
Feldman JL. Neural control of breathing. In: Squire LR, Bloom LE, McConnell SK,eds. Fundamental Neurocience. Amsterdam, New York: Academic Press;2003:967-90.
Burggren WW, Doyle M. Ontogeny of regulation of gill and lung ventilation in the bullfrog, Rana catesbeiana. Resp Physiol 1986:66:279-91.
Burggren WW, Pinder AW. Ontogeny of cardiovascular and respiratory physiology in lower vertebrates. Annu Resp Physiol 1991:53:107-35.
Wirimill RE, Hedrick MS. Developmental changes in the modulation of respiratory rhythm generation by extracellular K in the isolated bullfrog brainstem. JNeurobio12003; 55: 278- 7.
Di Pasquale E, Monteau R, Hilaire G. Involvement of the rostral ventro-lateral medulla in respiratory rhythm genesis during the perinatal period: an in vitro study in newborn and foetal rats. Brain Res 1994:78: 243-52.
Hilaire G, Duran B. Maturation of the mammals respiratory system. Physiol Rey 1999: 79: 325-60.
Viemari JC, Burnet H, Bevengut M. Hilaire G. Perinatal maturation of the mause respiratory rhythm generator: in vivo and invitro studies. Eur J Neurosct 2003: 17: 1233- 44.
Straus C, Wilson RJ, Remmers JE, Developmental desinhibition: turning off inhibition turns on breathing in vertebrates. J Neurobioí 2000;45: 75-83.
Broch L, Morales RD, Sandoval Ay, Hedrick MS. Regulation of the respiratory central pattem generator by chloride-dependent inhibition during development in the bullfrog (Rana catesbeiana). J Exp Biol 2002, 205:1161-9.
Be1zile O, Gulemetova R, Kinhead R Role of 5-HT, receptors in serotoninergic modulation of respiratory motor output during todpole development. Resp Physiol Neurobiol 2002; 133:277-82-1
Kinkehead R, Belzile O, Gulematova R. Serotoninergic modulation of respiratory motor output during todpole development. J Appl Physiol 2002;93: 936-46.
Belzile O, Gulematova R, Kinkehead R. Stage-dependent effect of raphe neuron stimulation on flctíve lug ventilation in Rana catesbeiana: role of SHT, receptors. F'ASEB J 2003; 17:A422.
Milsom WK. Control and coordination of gas exchange in air breathers ; chapter 10. Berlin-New York: Spriger Verlag, 1990: 34-400.
Milsom WK. Intermittent breathing in vertebrates. Annu Rey Physiol 1991; 53:88-105.
Kinkehead R, Milsom WK. Chemoreceptors and control of episodic breathing in the bullfrog (Rana catesbeiana). Respir Physiol 1994:95:87-105.
Kainicka 1, Diaz V, Darion D, Praud JP. Coordination between glotic adductor muscle and diphragm EMG activity in foetal lambs in utero. JApp( Physiol 1998: 84: 1560-5.
Kinkehead R, Milsom WK. Role of pulmonary streach receptors feedback in control of episodic breathing in the bullfrog. AmJPiiysiol 1997:272:R497-508.
Kinkehead R, Harns MB, Milsom WK. The role of the nucleus isthmi in respiratory pattern formation in bullfrog. JExp Biot 1997; 200:1781-93.
Straus C, Wilson RJ, Tezenas du Montcel S, Remmers JE. Baclofen eliminates cluster lung breathing of the todpole brainstem in vitro. Neurosci Lett 2000; 292: 13-6.
Yost CS. A new look at the respiratory stimulant doxapram. CNS Drug Rey 2006: 12: 236-49.
Gaulier C, Trana H, Douger S, Gallego J. Pediatric disorders with autonomic dysfunction: what the role for PHOX2B? Pediati-Res 2005; 58: 1-6.
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