Uncomplicated urinary tract infection in women: etiology and antimicrobial resistance
DOI:
https://doi.org/10.31053/1853.0605.v74.n3.10208Keywords:
cystitis, pyelonephritis, antibiotic resistance.Abstract
Our objectives were to determine the etiology and analyze the antibiotic resistance profiles of microorganisms causing uncomplicated urinary tract infections in our setting. An analytical cross-sectional study was conducted. In vitro antimicrobial resistance of urine cultures was analyzed. 580 urine cultures of women over age fifteen were included. 82.6 % of urine cultures corresponded to cystitis and the remaining 17.4 % corresponded to pyelonephritis. 353 urine cultures of women <50 years old (60.9%) and 227 of women ? 50 years old (39.1%) were obtained. The most common pathogens were Escherichia coli (85.5 %) and Klebsiella pneumoniae (4.7 %).For Escherichia coli, there was a resistance of 28.6% to trimethoprim-sulfamethoxazole,7.9% to ciprofloxacin and 0.4% to nitrofurantoin. Significant difference (p = 0.005) was seen in the resistance to ciprofloxacin in women ? 50 years old. Our data show there is a low in vitro resistance to nitrofurantoin.Downloads
References
Hooton TM. Uncomplicated urinary tract infection. N Engl J Med. 2012;366:1028-37.
Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med 2002; 113: 5S-13S.
Etienne M, Lefebvre E, Frebourg N, Hamel H, Pestel-Caron M, Caron F, Bacyst Study Group. Antibiotic treatment of acute uncomplicated cystitis based on rapid urine test and local epidemiology: lessons from a primary care series. BMC Infect Dis 2014;14:137.
Kamenski G, Wagner G, Zehetmayer S, Fink W, Spiegel W, Hoffmann K. Antibacterial resistances in uncomplicated urinary tract infections in women: ECO•SENS II data from primary health care in Austria. BMC Infect Dis. 2012 Sep18;12:222.
Schmiemann G, Gágyor I, Hummers-Pradier E, Bleidorn J. Resistance profiles of urinary tract infections in general practice-an observational study. BMC Urol. 2012 Nov 21;12:33.
Palou J, Pigrau C, Molina I, Ledesma JM, Angulo J; Etiology and sensitivity of uropathogens identified in uncomplicated lower urinary tract infections in women (ARESC Study): implications on empiric therapy. Med Clin (Barc). 2011 Jan 15;136(1):1-7.
Kahlmeter G. Prevalence and antimicrobial susceptibility of uncomplicated cystitis in Europe. The ECO.SENS Study. Int J Antimicrob Agents 2003; 22(Suppl. 2):49-52.
Rossi A, Tokumoto M, Galas M, Soloaga R, Corso A, et al..Vigilancia de la resistencia a los antibacterianos en Argentina. Programa WHONET, 1995–1996. Rev Panam Salud Publica 1999;6:234-41.
Levy Hara G, y cols. Informe Técnico. Consenso Argentino Intersociedades para el Manejo de la Infección del Tracto Urinario – Parte I. Rev Panam Infectol 2007;9(3):57-69. Link: http://www.revista-api.com/3%20edicao%202007/pdf/mat%2010.pdf.
Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonefritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 2011; 52:e103-e120.
Warren JW, Abrutyn E, Hebel JR, Johnson JR, Schaeffer AJ, Satamm WE. Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA). Clin Infect Dis 1999; 29:745-58.
The Medical Letter on Drugs and Therapeutics|February 26, 2014,
Drugs for Urinary Tract Infections. JAMA 2014;311(8):855-856.
Knottnerus BJ, Grigoryan L, Geerlings SE, Moll van Charante EP, Verheij TJ, Kessels AG, et al. Comparative effectiveness of antibiotics for uncomplicated urinary tract infections: Network meta-analysis of randomized trials. Fam Pract. 2012;29(6):659-70.
Gupta K, Hooton TM, Roberts PL, Stamm WE. Short-course nitrofurantoin for the treatment of acute uncomplicates cystitis in women. Arch Intern Med 2007; 167:2207-12.
Christiaens TC, De Meyere M, Verschraegen G, Peersman W, Heytens S, De Maeseneer JM. Randomised controlled trial of nitrofurantoin versus placebo in the treatment of uncomplicated urinary tract infection in adult women. Br J Gen Pract 2002; 52: 729-34
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