Administración crónica de drogas antiinflamatorios no esteroideos: Efectos en las funciones reproductivas en ratones

Autores/as

  • Ana C Martini Consejo de Investigaciones Científicas y Tecnológicas (CONICET)
  • Laura M Vincenti Instituto de Fisiología, Facultad de Cs Médicas. Universidad Nacional de Córdoba.
  • María E Santillán Instituto de Fisiología Facultad de Cs. Médicas. Universidad Nacional de Córdoba
  • Graciela Stutz Instituto de Fisiología. Facultad de Cs. Médicas. Universidad Nacional de Córdoba
  • Raquel Kaplan Instituto de Fisiología. Facultad de Cs. Médicas. Universidad Nacional de Córdoba
  • Rubén D Ruiz Consejo Nacional de Investigaciones Científicas y Tecnologicas (CONICET)
  • Marta Fiol de Cuneo Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET)

Palabras clave:

antiinflamatorios no esteroideos, prostaglandinas, reproducción, actividad funcional espermática, ovocito, ibuprofeno, piroxicam

Resumen

A pesar del frecuente empleo de los antiinflamatorios no esteroideos (AINEs), aún no se conocen los efectos secundarios de la inhibición crónica de las prostaglandinas. El objetivo del presente estudio fue evaluar los efectos del tratamiento crónico con dosis bajas/moderadas de AINEs sobre la función reproductiva de ratones. Ratones machos y hembras fueron inyectados (i.p. durante 60 ó 35 días respectivamente) con: dosis A, B o C de ibuprofeno (0.56, 1.12 ó 1.68mg/100g/día respectivamente) or dosis A, B o C de piroxicam (0.028, 0.056 ó 0.084mg/100g/día respectivamente). Los parámetros evaluados fueron: a) en hembras, ovulación espontánea e inducida, maduración ovocitaria y migración de espermatozoides a través del tracto genital, b) en machos y en espermatozoides epididimarios, concentración, motilidad, vitalidad, resistencia al shock hipoosmótico, estadío acrosomal y madurez de membrana y c) en ambos sexos, fertilización in vivo e in vitro, niveles plasmáticos de hormonas reproductivas e inhibición de ciclooxigenasa en tejido reproductivo. En las hembras, ibuprofeno (dosis A) disminuyó significativamente la ovulación espontánea e inducida y piroxicam (dosis A) disminuyó la concentración de espermatozoides en el tracto genital de la hembra luego de la cópula. Los espermatozoides obtenidos de machos tratados con ibuprofeno (dosis B) mostraron una disminución en su capacidad fertilizante in vitro. Nuestros datos revelan que la administración crónica de ibuprofeno o piroxicam pueden ejercer efectos deletéreos sobre la fisiología reproductiva, que dependen de la dosis y/o la droga empleada.

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Citas

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Publicado

2020-02-18

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1.
Martini AC, Vincenti LM, Santillán ME, Stutz G, Kaplan R, Ruiz RD, Fiol de Cuneo M. Administración crónica de drogas antiinflamatorios no esteroideos: Efectos en las funciones reproductivas en ratones. Rev Fac Cien Med Univ Nac Cordoba [Internet]. 18 de febrero de 2020 [citado 29 de marzo de 2024];65(2):41-5. Disponible en: https://revistas.unc.edu.ar/index.php/med/article/view/27715

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