Palavras-chave
psiquiatria
imunologia
neurologia
endocrinologia
lipídios bioativos
resolução
homeostase
Como Citar
Resumo
Há evidências substanciais que sugerem que várias condições psiquiátricas (incluindo estresse e depressão), vários distúrbios imunológicos, certas condições neurológicas e anormalidades endócrinas são processos inflamatórios sistêmicos de “baixo grau” nos quais os mediadores pró-inflamatórios são substancialmente aumentados enquanto a disponibilidade de anti-moléculas inflamatórias é deficiente. Este desequilíbrio entre as moléculas envolvidas na inflamação e a regulação da resposta imune faz com que o equilíbrio homeostático se desloque mais para eventos e circunstâncias pró-inflamatórias, condições que podem causar o aparecimento, progressão e durabilidade das doenças supracitadas. Diante dessas condições, estratégias destinadas a aumentar as concentrações de moléculas anti-inflamatórias e diminuir ou suprimir a produção e ação inadequada de mediadores pró-inflamatórios podem representar uma nova abordagem para muitas doenças. Citocinas, lipídios bioativos, os sistemas enzimáticos correspondentes e seus precursores específicos, juntamente com suas moléculas associadas, parecem estar no centro desse desequilíbrio entre eventos pró-inflamatórios e anti-inflamatórios. Com base nas evidências atuais, uma nova abordagem é sugerida na prevenção e tratamento de várias doenças e patologias crônicas com base na administração adequada de lipídios bioativos, ácidos araquidônico, eicosapentaenoico e docosahexaenóico e citocinas anti-inflamatórias, como IL-4 e IL- 10 e antioxidantes como glutationa, vitaminas C, B1, B6, B12 e outros cofatores necessários para restabelecer o equilíbrio entre os eventos pró-inflamatórios e anti-inflamatórios e restaurar a homeostase sistêmica.
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