Palabras clave
psiquiatría
inmunología
neurología
endocrinología
lípidos bioactivos
resolución
homeostasis
Cómo citar
Resumen
Existe evidencia sustancial que varias condiciones psiquiátricas (incluyendo el estrés y la depresión), diversos trastornos inmunológicos, ciertas afecciones neurológicas, y algunas anomalías endócrinas, serían procesos inflamatorios sistémicos de “bajo grado” en los cuales los mediadores proinflamatorios estarían aumentados y la disponibilidad de moléculas antiinflamatorias disminuida. Este desequilibrio entre moléculas involucradas en la regulación de la respuesta inmune resultaría en un desplazamiento de la homeoestasis hacia eventos y circunstancias proinflamatorias, influyendo en el inicio, progresión y duración de las enfermedades mencionadas. Dado que las citoquinas y sus moléculas asociadas estarían en el centro de ese desequilibrio, sugerimos aquí que la administración de cantidades apropiadas de lípidos bioactivos tales como ácidos araquidónico eicosapentaenoico y docosahexaenoico, citoquinas antiinflamatorias IL-4 e IL-10, el antioxidante glutatión, las vitaminas C, B1, B6, B12, y otros cofactores, podría constituir una estrategia novedosa para el tratamiento de estas enfermedades.
Citas
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