Palabras clave
psiquiatría
inmunología
neurología
endocrinología
lípidos bioactivos
resolución
homeostasis
Cómo citar
Resumen
Existe evidencia sustancial que varias condiciones psiquiátricas (incluyendo el estrés y la depresión), diversos trastornos inmunológicos, ciertas afecciones neurológicas, y algunas anomalías endócrinas, serían procesos inflamatorios sistémicos de “bajo grado” en los cuales los mediadores proinflamatorios estarían aumentados y la disponibilidad de moléculas antiinflamatorias disminuida. Este desequilibrio entre moléculas involucradas en la regulación de la respuesta inmune resultaría en un desplazamiento de la homeoestasis hacia eventos y circunstancias proinflamatorias, influyendo en el inicio, progresión y duración de las enfermedades mencionadas. Dado que las citoquinas y sus moléculas asociadas estarían en el centro de ese desequilibrio, sugerimos aquí que la administración de cantidades apropiadas de lípidos bioactivos tales como ácidos araquidónico eicosapentaenoico y docosahexaenoico, citoquinas antiinflamatorias IL-4 e IL-10, el antioxidante glutatión, las vitaminas C, B1, B6, B12, y otros cofactores, podría constituir una estrategia novedosa para el tratamiento de estas enfermedades.
Referencias
Antonopoulos, A. S., Papanikolaou, E., Vogiatzi, G., Oikonomou, E., & Tousoulis, D. (2018). Anti-inflammatory agents in peripheral arterial disease. Current opinion in pharmacology, 39, 1–8. https://doi.org/10.1016/j.coph.2017.11.001
Arrese, M., Cabrera, D., Kalergis, A. M., & Feldstein, A. E. (2016). Innate Immunity and Inflammation in NAFLD/NASH. Digestive diseases and sciences, 61(5), 1294–1303. https://doi.org/10.1007/s10620-016-4049-x
Berenbaum F. (2013). Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis and cartilage, 21(1), 16–21. https://doi.org/10.1016/j.joca.2012.11.012
Berk, M., Williams, L. J., Jacka, F. N., O'Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., & Maes, M. (2013). So depression is an inflammatory disease, but where does the inflammation come from?. BMC medicine, 11, 200. https://doi.org/10.1186/1741-7015-11-200
Calsolaro, V., & Edison, P. (2016). Neuroinflammation in Alzheimer's disease: Current evidence and future directions. Alzheimer's & dementia : the journal of the Alzheimer's Association, 12(6), 719–732. https://doi.org/10.1016/j.jalz.2016.02.010
Chatterjee, A., Sharma, A., Chen, M., Toy, R., Mottola, G., & Conte, M. S. (2014). The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. PloS one, 9(11), e113480. https://doi.org/10.1371/journal.pone.0113480
Das U. N. (2001). Is obesity an inflammatory condition?. Nutrition (Burbank, Los Angeles County, Calif.), 17(11-12), 953–966. https://doi.org/10.1016/s0899-9007(01)00672-4
Das U. N. (2006). Hypertension as a low-grade systemic inflammatory condition that has its origins in the perinatal period. The Journal of the Association of Physicians of India, 54, 133–142.
Das U. N. (2007). Is depression a low-grade systemic inflammatory condition?. The American journal of clinical nutrition, 85(6), 1665–1666. https://doi.org/10.1093/ajcn/85.6.1665
Das U. N. (2008). Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. Lipids in health and disease, 7, 37. https://doi.org/10.1186/1476-511X-7-37
Das U. N. (2020). Bioactive Lipids in Age-Related Disorders. Advances in experimental medicine and biology, 1260, 33–83. https://doi.org/10.1007/978-3-030-42667-5_3
Das U. N. (2021). Essential Fatty Acids and Their Metabolites in the Pathobiology of Inflammation and Its Resolution. Biomolecules, 11(12), 1873. https://doi.org/10.3390/biom11121873
Das U. N. (2022). Arachidonic Acid as Mechanotransducer of Renin Cell Baroreceptor. Nutrients, 14(4), 749. https://doi.org/10.3390/nu14040749
Dinh, Q. N., Drummond, G. R., Sobey, C. G., & Chrissobolis, S. (2014). Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. BioMed research international, 2014, 406960. https://doi.org/10.1155/2014/406960
Fang, X., Wang, H., Ye, T., Fu, X., Tan, X., Zeng, Y., Fan, J., & Xu, Y. (2021). Low serum Maresin-1 levels are associated with non-alcoholic fatty liver disease: a cross-sectional study. Lipids in health and disease, 20(1), 96. https://doi.org/10.1186/s12944-021-01518-5
Guo, H., Callaway, J. B., & Ting, J. P. (2015). Inflammasomes: mechanism of action, role in disease, and therapeutics. Nature medicine, 21(7), 677–687. https://doi.org/10.1038/nm.3893
Hameed, I., Masoodi, S. R., Mir, S. A., Nabi, M., Ghazanfar, K., & Ganai, B. A. (2015). Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition. World journal of diabetes, 6(4), 598–612. https://doi.org/10.4239/wjd.v6.i4.598
Kohli, P., & Levy, B. D. (2009). Resolvins and protectins: mediating solutions to inflammation. British journal of pharmacology, 158(4), 960–971. https://doi.org/10.1111/j.1476-5381.2009.00290.x
Li, H., Sun, K., Zhao, R., Hu, J., Hao, Z., Wang, F., Lu, Y., Liu, F., & Zhang, Y. (2018). Inflammatory biomarkers of coronary heart disease. Frontiers in bioscience (Scholar edition), 10(1), 185–196. https://doi.org/10.2741/s508
Liu, X., Wang, J., Wang, H., Yin, G., Liu, Y., Lei, X., & Xiang, M. (2015). REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop. Cancer letters, 362(1), 45–60. https://doi.org/10.1016/j.canlet.2015.03.014
Müller N. (2018). Inflammation in Schizophrenia: Pathogenetic Aspects and Therapeutic Considerations. Schizophrenia bulletin, 44(5), 973–982. https://doi.org/10.1093/schbul/sby024
Parola, M., & Pinzani, M. (2019). Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues. Molecular aspects of medicine, 65, 37–55. https://doi.org/10.1016/j.mam.2018.09.002
Poorani, R., Bhatt, A. N., Dwarakanath, B. S., & Das, U. N. (2016). COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance. European journal of pharmacology, 785, 116–132. https://doi.org/10.1016/j.ejphar.2015.08.0 49
Ramon, S., Dalli, J., Sanger, J. M., Winkler, J. W., Aursnes, M., Tungen, J. E., Hansen, T. V., & Serhan, C. N. (2016). The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation. The American journal of pathology, 186(4), 962–973. https://doi.org/10.1016/j.ajpath.2015.12.012
Rincón-Arévalo, H., Quintero, J. C., Fortich, F., Rojas, M., Vásquez, G., Castaño, D., & Yassin, L. M. (2020). Low frequency of IL-10+ B cells in patients with atherosclerosis is related with inflammatory condition. Heliyon, 6(3), e03441. https://doi.org/10.1016/j.heliyon.2020.e03441
Serhan C. N. (2005). Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins, leukotrienes, and essential fatty acids, 73(3-4), 141–162. https://doi.org/10.1016/j.plefa.2005.05.002
Serhan C. N. (2010). Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?. The American journal of pathology, 177(4), 1576–1591. https://doi.org/10.2353/ajpath.2010.100322
Serhan C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92–101. https://doi.org/10.1038/nature13479
Valenzuela, R., Das, U. N., Videla, L. A., & Llorente, C. G. (2018). Nutrients and Diet: A Relationship between Oxidative Stress, Aging, Obesity, and Related Noncommunicable Diseases. Oxidative medicine and cellular longevity, 2018, 7460453. https://doi.org/10.1155/2018/7460453
Zhu, Y., Xian, X., Wang, Z., Bi, Y., Chen, Q., Han, X., Tang, D., & Chen, R. (2018). Research Progress on the Relationship between Atherosclerosis and Inflammation. Biomolecules, 8(3), 80. https://doi.org/10.3390/biom8030080
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
Derechos de autor 2022 Pinelatinoamericana