Papel de los Lípidos Bioactivos en Psiquiatría, Inmunología, Neurología y Endocrinología (PINE)
HTML (Inglés)
HTML Trad
PDF (Inglés)
PDF Trad

Palabras clave

inflamación
psiquiatría
inmunología
neurología
endocrinología
lípidos bioactivos
resolución
homeostasis

Cómo citar

Papel de los Lípidos Bioactivos en Psiquiatría, Inmunología, Neurología y Endocrinología (PINE). (2022). Pinelatinoamericana, 2(1), 56-81. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/37046

Resumen

Existe evidencia sustancial que varias condiciones psiquiátricas (incluyendo el estrés y la depresión), diversos trastornos inmunológicos, ciertas afecciones neurológicas, y algunas anomalías endócrinas, serían procesos inflamatorios sistémicos de “bajo grado” en los cuales los mediadores proinflamatorios estarían aumentados y la disponibilidad de moléculas antiinflamatorias disminuida. Este desequilibrio entre moléculas involucradas en la regulación de la respuesta inmune resultaría en un desplazamiento de la homeoestasis hacia eventos y circunstancias proinflamatorias, influyendo en el inicio, progresión y duración de las enfermedades mencionadas. Dado que las citoquinas y sus moléculas asociadas estarían en el centro de ese desequilibrio, sugerimos aquí que la administración de cantidades apropiadas de lípidos bioactivos tales como ácidos araquidónico eicosapentaenoico y docosahexaenoico, citoquinas antiinflamatorias IL-4 e IL-10, el antioxidante glutatión, las vitaminas C, B1, B6, B12, y otros cofactores, podría constituir una estrategia novedosa para el tratamiento de estas enfermedades.

HTML (Inglés)
HTML Trad
PDF (Inglés)
PDF Trad

Referencias

Antonopoulos, A. S., Papanikolaou, E., Vogiatzi, G., Oikonomou, E., & Tousoulis, D. (2018). Anti-inflammatory agents in peripheral arterial disease. Current opinion in pharmacology, 39, 1–8. https://doi.org/10.1016/j.coph.2017.11.001

Arrese, M., Cabrera, D., Kalergis, A. M., & Feldstein, A. E. (2016). Innate Immunity and Inflammation in NAFLD/NASH. Digestive diseases and sciences, 61(5), 1294–1303. https://doi.org/10.1007/s10620-016-4049-x

Berenbaum F. (2013). Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis and cartilage, 21(1), 16–21. https://doi.org/10.1016/j.joca.2012.11.012

Berk, M., Williams, L. J., Jacka, F. N., O'Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., & Maes, M. (2013). So depression is an inflammatory disease, but where does the inflammation come from?. BMC medicine, 11, 200. https://doi.org/10.1186/1741-7015-11-200

Calsolaro, V., & Edison, P. (2016). Neuroinflammation in Alzheimer's disease: Current evidence and future directions. Alzheimer's & dementia : the journal of the Alzheimer's Association, 12(6), 719–732. https://doi.org/10.1016/j.jalz.2016.02.010

Chatterjee, A., Sharma, A., Chen, M., Toy, R., Mottola, G., & Conte, M. S. (2014). The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. PloS one, 9(11), e113480. https://doi.org/10.1371/journal.pone.0113480

Das U. N. (2001). Is obesity an inflammatory condition?. Nutrition (Burbank, Los Angeles County, Calif.), 17(11-12), 953–966. https://doi.org/10.1016/s0899-9007(01)00672-4

Das U. N. (2006). Hypertension as a low-grade systemic inflammatory condition that has its origins in the perinatal period. The Journal of the Association of Physicians of India, 54, 133–142.

Das U. N. (2007). Is depression a low-grade systemic inflammatory condition?. The American journal of clinical nutrition, 85(6), 1665–1666. https://doi.org/10.1093/ajcn/85.6.1665

Das U. N. (2008). Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. Lipids in health and disease, 7, 37. https://doi.org/10.1186/1476-511X-7-37

Das U. N. (2020). Bioactive Lipids in Age-Related Disorders. Advances in experimental medicine and biology, 1260, 33–83. https://doi.org/10.1007/978-3-030-42667-5_3

Das U. N. (2021). Essential Fatty Acids and Their Metabolites in the Pathobiology of Inflammation and Its Resolution. Biomolecules, 11(12), 1873. https://doi.org/10.3390/biom11121873

Das U. N. (2022). Arachidonic Acid as Mechanotransducer of Renin Cell Baroreceptor. Nutrients, 14(4), 749. https://doi.org/10.3390/nu14040749

Dinh, Q. N., Drummond, G. R., Sobey, C. G., & Chrissobolis, S. (2014). Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. BioMed research international, 2014, 406960. https://doi.org/10.1155/2014/406960

Fang, X., Wang, H., Ye, T., Fu, X., Tan, X., Zeng, Y., Fan, J., & Xu, Y. (2021). Low serum Maresin-1 levels are associated with non-alcoholic fatty liver disease: a cross-sectional study. Lipids in health and disease, 20(1), 96. https://doi.org/10.1186/s12944-021-01518-5

Guo, H., Callaway, J. B., & Ting, J. P. (2015). Inflammasomes: mechanism of action, role in disease, and therapeutics. Nature medicine, 21(7), 677–687. https://doi.org/10.1038/nm.3893

Hameed, I., Masoodi, S. R., Mir, S. A., Nabi, M., Ghazanfar, K., & Ganai, B. A. (2015). Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition. World journal of diabetes, 6(4), 598–612. https://doi.org/10.4239/wjd.v6.i4.598

Kohli, P., & Levy, B. D. (2009). Resolvins and protectins: mediating solutions to inflammation. British journal of pharmacology, 158(4), 960–971. https://doi.org/10.1111/j.1476-5381.2009.00290.x

Li, H., Sun, K., Zhao, R., Hu, J., Hao, Z., Wang, F., Lu, Y., Liu, F., & Zhang, Y. (2018). Inflammatory biomarkers of coronary heart disease. Frontiers in bioscience (Scholar edition), 10(1), 185–196. https://doi.org/10.2741/s508

Liu, X., Wang, J., Wang, H., Yin, G., Liu, Y., Lei, X., & Xiang, M. (2015). REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop. Cancer letters, 362(1), 45–60. https://doi.org/10.1016/j.canlet.2015.03.014

Müller N. (2018). Inflammation in Schizophrenia: Pathogenetic Aspects and Therapeutic Considerations. Schizophrenia bulletin, 44(5), 973–982. https://doi.org/10.1093/schbul/sby024

Parola, M., & Pinzani, M. (2019). Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues. Molecular aspects of medicine, 65, 37–55. https://doi.org/10.1016/j.mam.2018.09.002

Poorani, R., Bhatt, A. N., Dwarakanath, B. S., & Das, U. N. (2016). COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance. European journal of pharmacology, 785, 116–132. https://doi.org/10.1016/j.ejphar.2015.08.0 49

Ramon, S., Dalli, J., Sanger, J. M., Winkler, J. W., Aursnes, M., Tungen, J. E., Hansen, T. V., & Serhan, C. N. (2016). The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation. The American journal of pathology, 186(4), 962–973. https://doi.org/10.1016/j.ajpath.2015.12.012

Rincón-Arévalo, H., Quintero, J. C., Fortich, F., Rojas, M., Vásquez, G., Castaño, D., & Yassin, L. M. (2020). Low frequency of IL-10+ B cells in patients with atherosclerosis is related with inflammatory condition. Heliyon, 6(3), e03441. https://doi.org/10.1016/j.heliyon.2020.e03441

Serhan C. N. (2005). Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins, leukotrienes, and essential fatty acids, 73(3-4), 141–162. https://doi.org/10.1016/j.plefa.2005.05.002

Serhan C. N. (2010). Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?. The American journal of pathology, 177(4), 1576–1591. https://doi.org/10.2353/ajpath.2010.100322

Serhan C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92–101. https://doi.org/10.1038/nature13479

Valenzuela, R., Das, U. N., Videla, L. A., & Llorente, C. G. (2018). Nutrients and Diet: A Relationship between Oxidative Stress, Aging, Obesity, and Related Noncommunicable Diseases. Oxidative medicine and cellular longevity, 2018, 7460453. https://doi.org/10.1155/2018/7460453

Zhu, Y., Xian, X., Wang, Z., Bi, Y., Chen, Q., Han, X., Tang, D., & Chen, R. (2018). Research Progress on the Relationship between Atherosclerosis and Inflammation. Biomolecules, 8(3), 80. https://doi.org/10.3390/biom8030080

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

Derechos de autor 2022 Pinelatinoamericana

Downloads

Download data is not yet available.