Efecto del haloperidol sobre el contraste sucesivo positivo consumatorio en ratas adultas con aislamiento adolescente

Contenido principal del artículo

Lucas Cuenya
Matías Serafini
Alba Mustaca
Giselle Kamenetzky

Resumen

Las ratas expuestas a aislamiento adolescente (AA) muestran alteraciones neurológicas y conductuales en la adultez, muchas de ellas relacionadas con cambios en la respuesta ante reforzadores apetitivos. En estudios previos las ratas con AA mostraron un incremento del Contraste Sucesivo Positivo consumatorio(CSPc, i.e, mayor consumo de una solución azucarada al 32%, 24 hs después de tener acceso a una solución al 4%), respecto de animales sin AA. El objetivo de este estudio fue evaluar si este efecto está asociado a la hiperactividad dopaminérgica. Se administró haloperidol a animales con AA (0.1 mg/kg, i.p.) antes de los ensayos de incremento del refuerzo y salina a un grupo control. No se halló CSPc en los animales que recibieron haloperidol, mientras que en los sujetos con salina se observó en un ensayo. Si bien los resultados apoyan la hipótesis propuesta, es necesario realizar futuros experimentos para determinar con mayor precisión el correlato neuroquímico del incremento de CSPc en animales con AA.

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Cuenya, L., Serafini, M., Mustaca, A., & Kamenetzky, G. (2015). Efecto del haloperidol sobre el contraste sucesivo positivo consumatorio en ratas adultas con aislamiento adolescente. Revista Argentina De Ciencias Del Comportamiento, 7(2), 30–37. https://doi.org/10.32348/1852.4206.v7.n2.9482
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Artículos Originales
Biografía del autor/a

Lucas Cuenya, Universidad de Buenos Aires. Instituto de Investigaciones Médicas. Laboratorio de Psicología Experimental y Aplicada

Doctor en Psicología de la Universidad Nacional de Córdoba, docente de la asignatura Estadística en la Fac. de Psicología (UBA), Investigador Asistente de CONICET.

Citas

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