Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation

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Published: Jul 22, 2015
DOI: https://doi.org/10.32348/1852.4206.v7.n2.9482
Keywords:
adolescent isolation, positive contrast, haloperidol, dopamine, rat

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Lucas Cuenya
Universidad de Buenos Aires. Instituto de Investigaciones Médicas. Laboratorio de Psicología Experimental y Aplicada
Matías Serafini
Universidad de Buenos Aires. Instituto de Investigaciones Médicas. Laboratorio de Psicología Experimental y Aplicada
Alba Mustaca
Universidad Abierta Interamericana. Centro del Altos Estudios en Ciencias Humanas y de la Salud
Giselle Kamenetzky
Universidad Abierta Interamericana. Centro del Altos Estudios en Ciencias Humanas y de la Salud

Abstract

Rats exposed to adolescent isolation (AA) show neurological and behavioral disorders into adulthood, many of them related to changes in response to appetitive reinforcers. Previous studies showed an increase of consummatory Successive Positive Contrast(cSPC, i.e., increased consumption of 32% sugar solution, 24 hours after having access to 4% solution) in rats exposed to AA, in comparison to animals without AA. This study aim at evaluating whether this effect is associated with dopaminergic hyperactivity. Haloperidol (0.1 mg / kg, i.p.) was administered before animals with AA were exposed to the presentation of the increased solution (4% to 32%), while saline was administered to the control group. cSPC effect was not observed in animals receiving haloperidol, while a one trial positive contrast was expressed in animals receiving saline. These results confirm the proposed hypothesis. Although the results are promising, further experiments are needed to determine more precisely the neurochemical correlate of increased cSPC in animals with AA.

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How to Cite
Cuenya, L., Serafini, M., Mustaca, A., & Kamenetzky, G. (2015). Effect of haloperidol on consummatory successive positive contrast in adult rats with adolescent isolation. Argentinean Journal of Behavioral Sciences, 7(2), 30–37. https://doi.org/10.32348/1852.4206.v7.n2.9482
Issue
Vol. 7 No. 2 (2015): Revista Argentina de Ciencias del Comportamiento
Section
Original Articles

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Author Biography

Lucas Cuenya, Universidad de Buenos Aires. Instituto de Investigaciones Médicas. Laboratorio de Psicología Experimental y Aplicada

Doctor en Psicología de la Universidad Nacional de Córdoba, docente de la asignatura Estadística en la Fac. de Psicología (UBA), Investigador Asistente de CONICET.

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