Keywords
low grade inflammation
nervous system
How to Cite
Abstract
It will be reviewed how the typical cascade of inflammation begins emphasizing that this normal sequential process conforms the final path of the organism to recover its homeostasis being a global response of the whole body, evolutionarily preserved against macro and microscopic injuries. The development and progression of chronic diseases or conditions, particularly chronic stress, closely related to low-grade or subclinical inflammations induced by several aggressors (physical, environmental or psychological) will be discussed. The cross-talk among basic cellular and molecular aspects of inflammation, the local and systemic immune processes regulating pro- and anti-inflammatory molecules of innate and acquired immunity will be analyzed as well it will be the interconnected feedback among neuronal pathways, their encephalic nuclei and endocrine responses in healthy conditions. The systemic alterations that develop in these systems when occurs a sustained aggression by chronic stress will be pointed out. It is concluded that the professionals who are members of the health team must work together and guide adults in order to educate their children to acquire healthy lifestyle habits that may avoid, prevent and alleviate the condition of chronic inflammation and stress.
References
Bennett J.M., Reeves G., Billman, G.E. y Sturmberg, J.P. (2018) Inflammation–Nature's Way to Efficiently Respond to All Types of Challenges: Implications for Understanding and Managing “the Epidemic” of Chronic Diseases. Front Med (Lausanne,), 5, 316. https://doi.org/10.3389/fmed.2018.00316
Dantas, R.L., Freff, J., Ambrée, O., Beins, E.C., Andreas, J., Forstner, A.J., Dannlowski,U., Baune, B.T., Scheu, S. y Alferink, J. (2021) Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders?. Cells, 10, 941. https://doi.org/10.3390/cells10040941
Diaz- Gerevini ,G.T., Daín, A., Pasqualini, M.B., López, C.B., Eynard, A.R. y Repossi ,G. (2019) Diabetic encephalopathy: beneficial effects of supplementation with fatty acids ω3 and nordihydroguaiaretic acid in a spontaneous diabetes rat model. Lipids Health Dis,18. https://doi.org/10.1186/s12944-018-0938-7
Eynard, A.R. y Repossi, G. (2019). Role of ω3 polyunsaturated fatty acids in diabetic retinopathy: a morphological and metabolically cross talk among blood retina barriers damage, autoimmunity and chronic inflammation. Lipids Health Dis. 18, 114. https://doi.org/10.1186/s12944-019-1049-9
Eynard, A.R., Valentich, M.A. y Rovasio, R.A. (2016). Histología y Embriología Humanas, Bases Celulares y Moleculares con Orientación Clínico-Patológica, Buenos Aires: Editorial Médica Panamericana, 5ta. Ed. https://www.medicapanamericana.com/ar/libro/histologia-y-embriologia-humanas
Leighton, S.P., Nerurkar, L., Krishnadas, R., Johnman, C., Graham, G.J. y Cavanagh, J. (2018). Chemokines in Depression in Health and in Inflammatory Illness: A Systematic Review and Meta-Analysis. Mol Psychiatry 23, 48-58. https://doi.org/10.1038/mp.2017.205
Mac Cusker, R.H. & Kelley K.W. (2013). Immune–neural connections: how the immune systemʼs response to infectious agents influences behavior. J Exp Biology, 216: 84-98. https://doi.org/10.1242/jeb.073411
Ramirez, K., Fornaguera-Trías, J. y Sheridan, J.F. (2017). Stress-Induced Microglia Activation and Monocyte Trafficking to the Brain Underlie the Development of Anxiety and Depression. Curr. Top. Behav. Neurosci, 31, 155-172. https://doi.org/10.1007/7854_2016_25
Tiberi, M. y Chiurchiu, V. (2021). Specialized Pro-resolving Lipid Mediators and Glial Cells: Emerging Candidates for Brain Homeostasis and Repair. Front. Cell. Neurosci. 15. https://doi.org/10.3389/fncel.2021.673549
Velazquez, S. y Rappaport, J. (2016). Inflammasome activation in Major Depressive Disorder: A Pivotal Linkage Between Psychological Stress, Purinergic Signaling and the Kynurenine pathway. Biol Psychiatry. 80(1), 4–5. https://doi.org/10.1016/j.biopsych.2016.04.019
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