Low degree inflammation in the Nervous System and chronic stress: cellular and molecular pathophysiology

Abstract

It will be reviewed how the typical cascade of inflammation begins emphasizing that this normal sequential process conforms the final path of the organism to recover its homeostasis being a global response of the whole body, evolutionarily preserved against macro and microscopic injuries. The development and progression of chronic diseases or conditions, particularly chronic stress, closely related to low-grade or subclinical inflammations induced by several aggressors (physical, environmental or psychological) will be discussed. The cross-talk among basic cellular and molecular aspects of inflammation, the local and systemic immune processes regulating pro- and anti-inflammatory molecules of innate and acquired immunity will be analyzed as well it will be the interconnected feedback among neuronal pathways, their encephalic nuclei and endocrine responses in healthy conditions. The systemic alterations that develop in these systems when occurs a sustained aggression by chronic stress will be pointed out. It is concluded that the professionals who are members of the health team must work together and guide adults in order to educate their children to acquire healthy lifestyle habits that may avoid, prevent and alleviate the condition of chronic inflammation and stress.