HPV-associated Oral Epithelial Dysplasia: A case series
Keywords:
Papillomavirus Infections, Human papillomavirus 16, Oral epitelial, DisplasiaAbstract
Objective: The aim of this work was to study clinical features of HPV-associated Oral Epithelial Dysplasia (HPV-OED) and evaluate risk factors for this entity. Methods: There were retrieved clinical records of the Oral Pathology Department – Facultad de Odontología, Universidad Nacional de Córdoba with histopathological diagnostic of HPV-OED. Age, sex, site, tobacco and alcohol habit, chief complaint, clinical presentation, mechanical irritation associated, status of adjacent mucosa, presence of histopathologic koilocitosis, degree of epithelial dysplasia and PCR-HPV genotype were studied. Results: We found 11 cases that satisfied the diagnostic criteria for HPV-OED. HPV-OED was presented predominantly in females with a average age of 61 years old. The lateral border of the tongue was the most frequent site of presentation. Tobacco consumption was present in almost all cases. Painless, whitish plaques with a rough surface were the most common clinical presentation. Chronic mechanical irritation (CMI) was observed in nine cases, only two lesions didn´t have association with CMI. Koylocitosis was found in all cases as the most frequent histological feature. HPV-16 was found in 4/11 cases, being the most frequent genotype. Conclusion: Our findings suggest that HPV-OED could have distinctive features from that present in the genital mucosa. There are other risk factors for Oral HPV infection, not present in other mucosae, which should be study due to its influence in the viral cycle such as CMI. Also, further investigations are needed to address the HPV-OED prognosis.References
1. Koss, L. G. & Durfee, G. R. Unusual patterns of squamous epithelium of the uterine cervix: cytologic and pathologic study of koilocytotic atypia. Ann. N. Y. Acad. Sci. 63, 1245–1261 (1956).
2. Fornatora, M., Jones, A. C., Kerpel, S. & Freedman, P. Human papillomavirus-associated oral epithelial dysplasia (koilocytic dysplasia): an entity of unknown biologic potential. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 82, 47–56 (1996).
3. Woo, S.-B., Cashman, E. C. & Lerman, M. A. Human papillomavirus-associated oral intraepithelial neoplasia. Mod. Pathol. Off. J. U. S. Can. Acad. Pathol. Inc 26, 1288–1297 (2013).
4. Syrjänen, S. et al. Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis. 17 Suppl 1, 58–72 (2011).
5. Woo, S.-B. Oral pathology a comprehensive atlas and text. (Elsevier, 2017).
6. Argyris, P. P. & Koutlas, I. G. Oral Fibroma With HPV-Associated Epithelial Dysplasia: Even in Fibromas You Should Expect the Unexpected. Int. J. Surg. Pathol. 1066896913509013 (2013).
7. Klingbeil, M. F. G., De Lima, M. D. M., Gallottini, M. H. C., Dos Santos Pinto, D. & Lemos, C. A. Oral koilocytic dysplasia: long-term clinical control. A case report. Minerva Stomatol. 61, 289–294 (2012).
8. Lupato, V. et al. Prevalence and Determinants of Oral Human Papillomavirus Infection in 500 Young Adults from Italy. PloS One 12, e0170091 (2017).
9. Venezuela, R. F. et al. Human Papillomavirus (HPV) in Oral Cavity Lesions: Comparison with Other Oral Cancer Risk Factors. J. Microbiol. Res. 3, 228–233 (2013).
10. Tezal M, Scannapieco FA, Wactawski-Wende J & et al. LOcal inflammation and human papillomavirus status of head and neck cancers. Arch. Otolaryngol. Neck Surg. 138, 669–675 (2012).
11. Perry, B. J. et al. Sites of origin of oral cavity cancer in nonsmokers vs smokers: possible evidence of dental trauma carcinogenesis and its importance compared with human papillomavirus. JAMA Otolaryngol.-- Head Neck Surg. 141, 5–11 (2015).
12. van der Waal, I. & Axéll, T. Oral leukoplakia: a proposal for uniform reporting. Oral Oncol. 38, 521–526 (2002).
13. Maglennon, G. A. & Doorbar, J. The biology of papillomavirus latency. Open Virol. J. 6, 190–197 (2012).
14. Veldhuijzen, N. J., Snijders, P. J., Reiss, P., Meijer, C. J. & van de Wijgert, J. H. Factors affecting transmission of mucosal human papillomavirus. Lancet Infect. Dis. 10, 862–874 (2010).
15. Rautava, J. & Syrjänen, S. Biology of Human Papillomavirus Infections in Head and Neck Carcinogenesis. Head Neck Pathol. 6, 3–15 (2012).
16. Liu, X. et al. Chronic Inflammation-Related HPV: A Driving Force Speeds Oropharyngeal Carcinogenesis. PloS One 10, e0133681 (2015).
17. Eberhard Amtmann, M. S. Activation of latent papillomavirus genomes by chronic mechanical irritation. Journal of General Virology 72, 2787–2789, 2787 (1991).
18. Syrjänen, S., Rautava, J. & Syrjänen, K. HPV in Head and Neck Cancer—30 Years of History. in HPV Infection in Head and Neck Cancer (eds. Golusi?ski, W., Leemans, C. R. & Dietz, A.) 3–25 (Springer International Publishing, 2017). doi:10.1007/978-3-319-43580-0_1
19. Piemonte, E. D., Lazos, J. P. & Brunotto, M. Relationship between chronic trauma of the oral mucosa, oral potentially malignant disorders and oral cancer: Chronic trauma of the oral mucosa. J. Oral Pathol. Med. no-no (2010). doi:10.1111/j.1600-0714.2010.00901.x
20. Warnakulasuriya, S. Causes of oral cancer--an appraisal of controversies. Br. Dent. J. 207, 471–475 (2009).
21. Kero, K. et al. Smoking increases oral HPV persistence among men: 7-year follow-up study. Eur. J. Clin. Microbiol. Infect. Dis. 33, 123–133 (2014).
22. Tezal, M. Interaction between Chronic Inflammation and Oral HPV Infection in the Etiology of Head and Neck Cancers. Int. J. Otolaryngol. 2012, (2012).
23. Mallen-St Clair, J., Alani, M., Wang, M. B. & Srivatsan, E. S. Human papillomavirus in oropharyngeal cancer: The changing face of a disease. Biochim. Biophys. Acta 1866, 141–150 (2016).
24. Feller, L. & Lemmer, J. Oral Leukoplakia as It Relates to HPV Infection: A Review. Int. J. Dent. 2012, 540561 (2012).
25. González, J. V. et al. Human papillomavirus in oral lesions. Medicina (Mex.) 67, 363–368 (2007).
26. Blioumi, E. et al. Detection and typing of human papillomaviruses (HPV) in malignant, dysplastic, nondysplastic and normal oral epithelium by nested polymerase chain reaction, immunohistochemistry and transitional electron microscopy in patients of northern Greece. Oral Oncol. 50, 840–847 (2014).
27. Iwasaka, T. et al. ‘Hit and run’ oncogenesis by human papillomavirus type 18 DNA. Acta Obstet. Gynecol. Scand. 71, 219–223 (1992).
28. Syrjänen, S. The role of human papillomavirus infection in head and neck cancers. Ann. Oncol. Off. J. Eur. Soc. Med. Oncol. ESMO 21 Suppl 7, vii243-245 (2010).
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