First autochthonous Hepatitis E cases in Uruguay

Authors

  • J.C. Russi
  • M. Vacarezza
  • J.C. Vignolo
  • S. Mirazo
  • P. Kleist
  • S. Lissman
  • S. Parrillo
  • R. Silvariño
  • J. Stanham
  • H. Cohen

DOI:

https://doi.org/10.31052/1853.1180.v15.n1.7007

Keywords:

Hepatitis E, Emerging Disease, Autochthonous Cases

Abstract

In order to describe the first autochthonous Hepatitis E cases, we carried out a descriptive study. The population, 9 patients, was identified from November 2009 to July 2010. They were selected by specific IgG and IgM for HEV and we made viral RNA search in serum by RT-PCR. Patients average age was 51 years old, 8 male, tertiary education, upper middle socioeconomic level, health attention in private sector and urban residence. Clinic results similar to hepatitis A, with elevated transaminases over 1500 (mU/ml) and glutamic pyruvic with maximum values of 5270 (mU/ml). All patients presented hyperbilirubinemia (direct predominance) and increased gamma glutamyl transferase and alkaline phosphatase.

Circulation of HEV with clinical manifestations was demonstrated in Uruguay, this shows the presence of an emergent disease. We suggest introducing a formalized HEV diagnosis in patients without etiologic diagnosis of hepatitis.

Downloads

Download data is not yet available.

Author Biographies

J.C. Russi

Médico Virólogo, Hospital Británico, Ex Prof. Agregado de Microbiología.

M. Vacarezza

Méd. Infectóloga, Prof. Adjunta de Med. Interna (FMUdelaR).

J.C. Vignolo

Méd. Epidemiólogo, Prof. Tit. del Depto. de Med. Fam. y Comunitaria (F.Medicina- UdelaR).

S. Mirazo

Mter. en C. Biológicas, docente de Virología (F.Ciencias- UdelaR).

P. Kleist

Méd. Internista, Hosp. Británico.

S. Lissman

Méd. Internista, Gastroenteróloga, Prof. Adjunta (Escuela de Nutrición - UdelaR).

S. Parrillo

Doc. de la Maestría de Farmacología Clínica. Centro de C. Biomédicas (Univ. Montevideo).

R. Silvariño

Méd. Internista. Depto. de Medicina. Sanatorio Americano.

J. Stanham

Méd. Internista.Hosp. Británico. Esp. en Salud Pública. Ex Prof. Adj. de Clínica Médica (F.Medicina -UdelaR).

H. Cohen

Prof. Titular de la Clínica de Gastroenterología (F.Medicina - UdelaR)

Downloads

How to Cite

1.
Russi J, Vacarezza M, Vignolo J, Mirazo S, Kleist P, Lissman S, Parrillo S, Silvariño R, Stanham J, Cohen H. First autochthonous Hepatitis E cases in Uruguay. Rev. Salud Pública (Córdoba) [Internet]. 2014 Mar. 31 [cited 2024 Jul. 17];15(1):6-16. Available from: https://revistas.unc.edu.ar/index.php/RSD/article/view/7007

Issue

Vol. 15 No. 1 (2011)

Section

Scientific Articles

License

Copyright (c) 2014 Escuela de Salud Pública y Ambiente. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License which allows the work to be copied, distributed, exhibited and interpreted as long as it is not done for commercial purposes.
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) after the publication process. (See The Effect of Open Access). (See The Effect of Open Access).