Las propiedades de refuerzo central del etanol están mediadas por sistemas de opiáceos endógenos: efectos de los antagonistas de los opiáceos Mu y Kappa

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Publicado: sept. 2, 2009
DOI: https://doi.org/10.32348/1852.4206.v1.n1.5299
Palabras clave:
infantil rata los receptores opiáceos etanol acondicionado

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Michael E. Nizhnikov
Binghamton University. Department of Psychology. Center for Development and Behavioral Neuroscience
Elena I. Varlinskaya
Binghamton University. Department of Psychology. Center for Development and Behavioral Neuroscience
Norman E. Spear
Binghamton University. Department of Psychology. Center for Development and Behavioral Neuroscience

Resumen

Los sistemas de opiáceos endógenos están implicados en los efectos reforzantes del alcohol y pueden desempeñar un papel sustancial en modular los efectos reforzantes centrales del etanol en la temprana ontogenia. El presente estudio indagó esta posibilidad a través de un paradigma de condicionamiento olfatorio en el que la administración central de etanol sirvió como estímulo incondicionado (EI). En el experimento 1, los neonatos de rata fueron pre-tratados con antagonistas selectivos para los receptores mu o kappa (CTOP y nor-BNI, respectivamente) y luego entrenados en condicionamiento olfatorio. El experimento 2 evaluó la capacidad de un antagonista kappa de corta duración (GNTI) en alterar la capacidad reforzante del etanol. El experimento 3 investigó si el bloqueo farmacológico de los receptores opiáceos podía causar una alteración inespecífica del condicionamiento olfatorio. Para ello se empleó como EI la administración intraoral de quinina. La administración central de los antagonistas opiáceos mu y kappa bloqueó los efectos reforzantes del etanol. La efectividad de GNTI fue similar a nor-BNI. Es poco probable que los efectos de antagonistas opiáceos sobre el reforzamiento al etanol sean explicados por una disrupción general de todos los tipos de condicionamiento; desde el momento en que CTOP no afecto el reforzamiento aversivo inducido por la infusión intraoral de quinina. Estos resultados respaldan la hipótesis de que las propiedades reforzantes del etanol en el neonato de rata están mediadas por la actividad endógena de los receptores opiáceos mu y kappa.

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Nizhnikov, M. E., Varlinskaya, E. I., & Spear, N. E. (2009). Las propiedades de refuerzo central del etanol están mediadas por sistemas de opiáceos endógenos: efectos de los antagonistas de los opiáceos Mu y Kappa. Revista Argentina De Ciencias Del Comportamiento, 1(1), 1–12. https://doi.org/10.32348/1852.4206.v1.n1.5299
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Vol 1, No 1 (2009): Revista Argentina de Ciencias del Comportamiento
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