Implicações do perfil genômico na vulnerabilidade emocional: seu potencial na previsão e prevenção de transtornos de saúde mental
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medicina de precisão
polimorfismos
vulnerabilidade emocional

Como Citar

Implicações do perfil genômico na vulnerabilidade emocional: seu potencial na previsão e prevenção de transtornos de saúde mental. (2024). Pinelatinoamericana, 4(1), 58-79. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/44431

Resumo

O humor e as emoções fazem parte da experiência consciente de todas as pessoas e podem influenciar as ações que tomam e as decisões que tomam. E, como todos os outros aspectos da psicologia, os humores vivenciados e as emoções sentidas são o produto da interação de neurotransmissores no cérebro. As neurociências identificaram muitos fatores diferentes que influenciam a probabilidade de experimentar certos estados de espírito e/ou vulnerabilidade emocional, e a genómica fornece a definição de marcadores que permitem determinar traços genéticos de risco ou suscetibilidade a sofrer de patologias psiquiátricas ou emocionais, como depressão e ansiedade.

A determinação dos traços genéticos, estabelecendo o perfil genómico através da avaliação de polimorfismos associados ao bem-estar emocional, constituem uma ferramenta útil para a tomada de decisões para a previsão e aplicação de estratégias de prevenção orientadas e precisas, que é hoje o objetivo do novo paradigma dos cuidados de saúde: medicina preditiva, preventiva e personalizada.

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Referências

Almond. M. (2013). Current Psychiatry. Current Psychiatry. 12 (6), 24-32. https://www.mdedge.com/psychiatry/article/76288/depression/depression-and-inflammation-examining-link

Attia, J., Ioannidis, J. P., Thakkinstian, A., McEvoy, M., Scott, R. J., Minelli, C., Thompson, J., Infante-Rivard, C. y Guyatt, G. (2009). How to use an article about genetic association: A: Background concepts. JAMA, 301(1), 74–81. https://doi.org/10.1001/jama.2008.901.

Attwells, S., Setiawan, E., Wilson, A. A., Rusjan, P. M., Mizrahi, R., Miler, L., Xu, C., Richter, M. A., Kahn, A., Kish, S. J., Houle, S., Ravindran, L. y Meyer, J. H. (2017). Inflammation in the Neurocircuitry of Obsessive-Compulsive Disorder. JAMA psychiatry, 74(8), 833–840. https://doi.org/10.1001/jamapsychiatry.2017.1567.

Berk, M., Williams, L. J., Jacka, F. N., O'Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L. y Maes, M. (2013). So depression is an inflammatory disease, but where does the inflammation come from?. BMC medicine, 11, 200. https://doi.org/10.1186/1741-7015-11-200

Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., Nickel, T., Künzel, H. E., Fuchs, B., Majer, M., Pfennig, A., Kern, N., Brunner, J., Modell, S., Baghai, T., Deiml, T., … Muller-Myhsok, B. (2004). Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nature genetics, 36(12), 1319–1325. https://doi.org/10.1038/ng1479.

Botstein, D. y Risch, N. (2003). Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nature genetics, 33 Suppl, 228–237. https://doi.org/10.1038/ng1090

Bottaccioli, A. G., y Bottaccioli, F. (2023). Los estados psíquicos se traducen en moléculas biológicas: las consecuencias para la medicina y la psicología. Pinelatinoamericana, 3(1), 54–89. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/40624

Bottaccioli, F. y Bottaccioli, A. (2022). La psiconeuroendocrinoinmunología, un paradigma sistémico de base molecular, fundamental para la salud del individuo y de la humanidad. Pinelatinoamericana 2, (3),178-184. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/39246.

Bottaso, O. (2022). La inflamación en el siglo XXI, desde los conceptos clásicos a una visión más extendida. Pinelatinoamericana, 2 (2), 116-124. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/38192.

Bragantini, D., Sivertsen, B., Gehrman, P., Lydersen, S. y Güzey, I. C. (2019). Genetic polymorphisms associated with sleep-related phenotypes; relationships with individual nocturnal symptoms of insomnia in the HUNT study. BMC medical genetics, 20(1), 179. https://doi.org/10.1186/s12881-019-0916-6.

Carpena, M. X., Hutz, M. H., Salatino-Oliveira, A., Polanczyk, G. V., Zeni, C., Schmitz, M., Chazan, R., Genro, J. P., Rohde, L. A. y Tovo-Rodrigues, L. (2019). CLOCK Polymorphisms in Attention-Deficit/Hyperactivity Disorder (ADHD): Further Evidence Linking Sleep and Circadian Disturbances and ADHD. Genes, 10(2), 88. https://doi.org/10.3390/genes10020088

Cólica, P. (2012). Estrés: lo que usted querría preguntar y debe conocer. Córdoba: Editorial Brujas.

Cólica, P. (2021). Conductas emocionales y estrés. Pinelatinoamericana, 1(1),12-17. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/36036.

Cortes Generales. Senado de España. (13 de febrero de 2019) Comparecencia de D. Ángel Carracedo Álvarez. Catedrático de Medicina Legal de la Universidad de Santiago de Compostela (a Coruña) y miembro de la Real Academia Gallega de Ciencias. Boletín Oficial de las Cortes Generales Senado (341); 108. https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwj58MCozMmEAxWQgpUCHSeRAkMQFnoECBUQAQ&url=https%3A%2F%2Fwww.senado.es%2Flegis12%2Fpublicaciones%2Fpdf%2Fsenado%2Fbocg%2FBOCG_D_12_341_2574.PDF&usg=AOvVaw2YcQ9ZV0ommVp3ad6bPRkZ&opi=89978449.

Das, U. N. y Pinelatinoamericana [trad.] (2022). Papel de los Lípidos Bioactivos en Psiquiatría, Inmunología, Neurología y Endocrinología (PINE) Pinelatinoamericana, 2(1), 56–81. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/37046.

de Morais, H., de Souza, C. P., da Silva, L. M., Ferreira, D. M., Baggio, C. H., Vanvossen, A. C., Cristina de Carvalho, M., da Silva-Santos, J. E., Bertoglio, L. J., Cunha, J. M. y Zanoveli, J. M. (2016). Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: Role of CB1 receptors. European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology, 26(10), 1590–1600. https://doi.org/10.1016/j.euroneuro.2016.08.007

Effendi, E. (2018). Exploring the link between inflammation and mental disorders. IOP Conf. Series: Earth and Environmental Science 125 012187. https://doi.org/10.1088/1755-1315/125/1/012187.

Eynard, A. R. (2021). Inflamación de “bajo grado” en el Sistema Nervioso y estrés crónico: aspectos celulares y moleculares básicos en su fisiopatología. Pinelatinoamericana, 1(1), 3–11. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/35444.

Furman, D. y Davis, M. M. (2015). New approaches to understanding the immune response to vaccination and infection. Vaccine, 33(40), 5271–5281. https://doi.org/10.1016/j.vaccine.2015.06.117.

Furman, D., Chang, J., Lartigue, L., Bolen, C. R., Haddad, F., Gaudilliere, B., Ganio, E. A., Fragiadakis, G. K., Spitzer, M. H., Douchet, I., Daburon, S., Moreau, J. F., Nolan, G. P., Blanco, P., Déchanet-Merville, J., Dekker, C. L., Jojic, V., Kuo, C. J., Davis, M. M. y Faustin, B. (2017). Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature medicine, 23(2), 174–184. https://doi.org/10.1038/nm.4267.

Gao, J., Pan, Z., Jiao, Z., Li, F., Zhao, G., Wei, Q., Pan, F. y Evangelou, E. (2012). TPH2 gene polymorphisms and major depression--a meta-analysis. PloS one, 7(5), e36721. https://doi.org/10.1371/journal.pone.0036721.

Goldsmith, D. R., Bekhbat, M., Mehta, N. D. y Felger, J. C. (2023). Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology. Biological psychiatry, 93(5), 405–418. https://doi.org/10.1016/j.biopsych.2022.11.003

Gottlieb, D. J., Hek, K., Chen, T. H., Watson, N. F., Eiriksdottir, G., Byrne, E. M., Cornelis, M., Warby, S. C., Bandinelli, S., Cherkas, L., Evans, D. S., Grabe, H. J., Lahti, J., Li, M., Lehtimäki, T., Lumley, T., Marciante, K. D., Pérusse, L., Psaty, B. M., Robbins, J., … Tiemeier, H. (2015). Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Molecular psychiatry, 20(10), 1232–1239. https://doi.org/10.1038/mp.2014.133.

Hanly, C., Shah, H., Au, P. Y. B. y Murias, K. (2021). Description of neurodevelopmental phenotypes associated with 10 genetic neurodevelopmental disorders: A scoping review. Clinical genetics, 99(3), 335–346. https://doi.org/10.1111/cge.13882.

Hernandez-Mixteco, M., Bernal-Morales, B., Valenzuela, O. L., Rodríguez-Landa, J. F., Cerna-Cortes, J. F. y García-Montalvo, E. A. (2023). TPH2-703 G/T polymorphism is associated with stress, depression, and psychosocial symptoms in mentally healthy Mexicans. Brain research, 1817, 148479. https://doi.org/10.1016/j.brainres.2023.148479.

Hernández-Romano, J., Martínez-Barnetche, J. y Valverde-Garduño, V. (2009). Polimorfismos reguladores y su participación en la patogenia de enfermedades complejas en la era posgenómica. Salud pública de Mexico, 51 Suppl 3, S455–S462. https://doi.org/10.1590/s0036-36342009000900011.

Hu, X. Y., Wu, Y. L., Cheng, C. H., Liu, X. X. y Zhou, L. (2021). Association of Brain-Derived Neurotrophic Factor rs6265 G>A polymorphism and Post-traumatic Stress Disorder susceptibility: A systematic review and meta-analysis. Brain and behavior, 11(5), e02118. https://doi.org/10.1002/brb3.2118.

Hu, Y., Shmygelska, A., Tran, D., Eriksson, N., Tung, J. Y. y Hinds, D. A. (2016). GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person. Nature communications, 7, 10448. https://doi.org/10.1038/ncomms10448.

Ising, M., Depping, A. M., Siebertz, A., Lucae, S., Unschuld, P. G., Kloiber, S., Horstmann, S., Uhr, M., Müller-Myhsok, B. y Holsboer, F. (2008). Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. The European journal of neuroscience, 28(2), 389–398. https://doi.org/10.1111/j.1460-9568.2008.06332.x.

Jin, P. y Wang, E. (2003). Polymorphism in clinical immunology - From HLA typing to immunogenetic profiling. Journal of translational medicine, 1(1), 8. https://doi.org/10.1186/1479-5876-1-8.

Jung, M. H., Park, B. L., Lee, B. C., Ro, Y., Park, R., Shin, H. D., Bae, J. S., Kang, T. C. y Choi, I. G. (2011). Association of CHRM2 polymorphisms with severity of alcohol dependence. Genes, brain, and behavior, 10(2), 253–256. https://doi.org/10.1111/j.1601-183X.2010.00663.x.

Kalmbach, D. A., Schneider, L. D., Cheung, J., Bertrand, S. J., Kariharan, T., Pack, A. I. y Gehrman, P. R. (2017). Genetic Basis of Chronotype in Humans: Insights From Three Landmark GWAS. Sleep, 40(2), zsw048. https://doi.org/10.1093/sleep/zsw048.

Klein, T. A., Neumann, J., Reuter, M., Hennig, J., von Cramon, D. Y. y Ullsperger, M. (2007). Genetically determined differences in learning from errors. Science (New York, N.Y.), 318(5856), 1642–1645. https://doi.org/10.1126/science.1145044.

Kovanen, L., Kaunisto, M., Donner, K., Saarikoski, S. T. y Partonen, T. (2013). CRY2 genetic variants associate with dysthymia. PloS one, 8(8), e71450. https://doi.org/10.1371/journal.pone.0071450.

Lo, M. T., Bandin, C., Yang, H. W., Scheer, F. A. J. L., Hu, K. y Garaulet, M. (2018). CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control. International journal of obesity (2005), 42(2), 190–197. https://doi.org/10.1038/ijo.2017.168.

Lodish, H., Berk, A., Kaiser, C. A., Krieger, M., Bretscher, A. Ploegh, H., Martin, K. C., Yaffe, M. B. y Amon, A. et al. (2005). Biología Celular y Molecular. (5° ed.) Editorial Panamericana.

López-Echeverri, Y. P., Cardona-Londoño, K. J., Garcia-Aguirre, J. F. y Orrego-Cardozo, M. (2023). Effects of serotonin transporter and receptor polymorphisms on depression. Revista Colombiana de psiquiatria (English ed.), 52(2), 130–138. https://doi.org/10.1016/j.rcpeng.2021.07.003

Magistrelli, L., Ferrari, M., Furgiuele, A., Milner, A. V., Contaldi, E., Comi, C., Cosentino, M. y Marino, F. (2021). Polymorphisms of Dopamine Receptor Genes and Parkinson's Disease: Clinical Relevance and Future Perspectives. International journal of molecular sciences, 22(7), 3781. https://doi.org/10.3390/ijms22073781.

Marquez Lopez-Mato, A. (2023). Neurobiología del amor. Pinelatinoamericana, 3(2), 90–102. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/41930.

Monteleone, P., Bifulco, M., Maina, G., Tortorella, A., Gazzerro, P., Proto, M. C., Di Filippo, C., Monteleone, F., Canestrelli, B., Buonerba, G., Bogetto, F. y Maj, M. (2010). Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. Pharmacological research, 61(5), 400–404. https://doi.org/10.1016/j.phrs.2010.01.002.

Mössner, R., Walitza, S., Geller, F., Scherag, A., Gutknecht, L., Jacob, C., Bogusch, L., Remschmidt, H., Simons, M., Herpertz-Dahlmann, B., Fleischhaker, C., Schulz, E., Warnke, A., Hinney, A., Wewetzer, C. y Lesch, K. P. (2006). Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. The international journal of neuropsychopharmacology, 9(4), 437–442. https://doi.org/10.1017/S1461145705005997.

National Human Genomic Research Institute. (s.f.). Glosario parlante de términos genómicos y genéticos. https://www.genome.gov/es/genetics-glossary.

Pagliai, G., Sofi, F., Dinu, M., Sticchi, E., Vannetti, F., Molino Lova, R., Ordovàs, J. M., Gori, A. M., Marcucci, R., Giusti, B. y Macchi, C. (2019). CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians - The MUGELLO Study. Scientific reports, 9(1), 1472. https://doi.org/10.1038/s41598-018-37992-8.

Peña, S., de la Vega, L., Nuñez, V., Pedemonte, M. y Dubourdieu, M. (2022). El sueño en el personal de salud durante la pandemia SARS-CoV-2 en Uruguay. Enfoque desde la Psiconeuroinmunoendocrinología (PNIE). Pinelatinoamericana, 2(3), 213–224. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/39184.

Ritchie, T. y Noble, E. P. (2003). Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics. Neurochemical research, 28(1), 73–82. https://doi.org/10.1023/a:1021648128758.

Ruan, Q., Qian, F. y Yu, Z. (2014). Effects of polymorphisms in immunity-related genes on the immune system and successful aging. Current opinion in immunology, 29, 49–55. https://doi.org/10.1016/j.coi.2014.04.003.

Salim, S., Chugh, G. y Asghar, M. (2012). Inflammation in anxiety. Advances in protein chemistry and structural biology, 88, 1–25. https://doi.org/10.1016/B978-0-12-398314-5.00001-5.

Tynan, R. J., Weidenhofer, J., Hinwood, M., Cairns, M. J., Day, T. A. y Walker, F. R. (2012). A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia. Brain, behavior, and immunity, 26(3), 469–479. https://doi.org/10.1016/j.bbi.2011.12.011.

Universidad Nacional del Córdoba. (17 de noviembre de 2022). Doctor Honoris Causa al Dr. Daniel Cardinali. [Archivo de Vídeo]. Youtube. https://www.youtube.com/watch?v=5tffqs4Xohs.

Watanabe, K., Jansen, P. R., Savage, J. E., Nandakumar, P., Wang, X., 23andMe Research Team, Hinds, D. A., Gelernter, J., Levey, D. F., Polimanti, R., Stein, M. B., Van Someren, E. J. W., Smit, A. B. y Posthuma, D. (2022). Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. Nature genetics, 54(8), 1125–1132. https://doi.org/10.1038/s41588-022-01124-w.

Xu, S., Kong, X. y Liu, J. (2021). Expression of CRY2 Gene in the Brain Is Related to Human Navigation. Frontiers in radiology, 1, 731070. https://doi.org/10.3389/fradi.2021.731070.

Xu, Y., Toh, K. L., Jones, C. R., Shin, J. Y., Fu, Y. H. y Ptácek, L. J. (2007). Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell, 128(1), 59–70. https://doi.org/10.1016/j.cell.2006.11.043

Zhang, J. P., Lencz, T. y Malhotra, A. K. (2010). D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis. The American journal of psychiatry, 167(7), 763–772. https://doi.org/10.1176/appi.ajp.2009.09040598

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