Keywords
stress
biomarkers
HDL
dysfunctional HDL
allostatic load
How to Cite
Abstract
The aim of this study was to determine the relationship between stress and sociodemographic variables and biomarkers of allostatic load in patients with acute coronary artery disease. Cross-sectional study, in patients with coronary artery disease confirmed by coronary angiography. Stress was measured by means of the perceived stress scale and the sociodemographic and clinical variables were taken from the medical records. Covariables were analyzed using descriptive statistics. Two groups were formed according to the presence or absence of stress at the time of hospitalization; the difference between the groups was evaluated. Correlation was explored by linear regression. A total of 138 patients were recruited, 50% of them were 65 years of age or older, 65.9% were men, acute myocardial infarction was the main diagnosis documented and the most frequent risk factor was arterial hypertension. Twenty-two-point eight percent of patients scored for stress. HDL was higher among patients with stress (Me 45.57) versus those without stress (Me 39.12), being a differentiating factor (p= 0.024). In the multivariate analysis, a positive relationship was found (r: 0.3; p: 0.003) of HDL with stress and an inverse relationship (r: -0.95; p: 0.02) of BMI with HDL in men. The results suggest a direct and significant relationship between elevated HDL levels and stress, and HDL may act as a proinflammatory factor in the acute stage of acute coronary disease.
References
Ansell, B. J., Navab, M., Hama, S., Kamranpour, N., Fonarow, G., Hough, G., Rahmani, S., Mottahedeh, R., Dave, R., Reddy, S. T., y Fogelman, A. M. (2003). Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment. Circulation, 108(22), 2751–2756. https://doi.org/10.1161/01.CIR.0000103624.14436.4B
Bacon, S. L., Ring, C., Lip, G. Y., y Carroll, D. (2004). Increases in lipids and immune cells in response to exercise and mental stress in patients with suspected coronary artery disease: effects of adjustment for shifts in plasma volume. Biological psychology, 65(3), 237–250. https://doi.org/10.1016/s0301-0511(03)00113-3
Barter, P. J., Nicholls, S., Rye, K. A., Anantharamaiah, G. M., Navab, M., y Fogelman, A. M. (2004). Antiinflammatory properties of HDL. Circulation research, 95(8), 764–772. https://doi.org/10.1161/01.RES.0000146094.59640.13
Besler, C., Heinrich, K., Rohrer, L., Doerries, C., Riwanto, M., Shih, D. M., Chroni, A., Yonekawa, K., Stein, S., Schaefer, N., Mueller, M., Akhmedov, A., Daniil, G., Manes, C., Templin, C., Wyss, C., Maier, W., Tanner, F. C., Matter, C. M., Corti, R., … Landmesser, U. (2011). Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. The Journal of clinical investigation, 121(7), 2693–2708. https://doi.org/10.1172/JCI42946
Bielas, H., Meister-Langraf, R. E., Schmid, J. P., Barth, J., Znoj, H., Schnyder, U., Princip, M., y von Känel, R. (2018). Acute stress disorder and C-reactive protein in patients with acute myocardial infarction. European journal of preventive cardiology, 25(3), 298–305. https://doi.org/10.1177/2047487317748506
Campo-Arias, A., Bustos-Leiton, G. J. y Romero- Chaparro, A. (2009). Consistencia interna y dimensionalidad de la Escala de Estrés Percibido (EEP-10 y EEP-14) en una muestra de universitarias de Bogotá, Colombia. Aquichan, 9(3), 271-280.
Castelli, W. P., Garrison, R. J., Wilson, P. W., Abbott, R. D., Kalousdian, S., y Kannel, W. B. (1986). Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. JAMA, 256(20), 2835–2838.
Cockerill, G. W., Huehns, T. Y., Weerasinghe, A., Stocker, C., Lerch, P. G., Miller, N. E., y Haskard, D. O. (2001). Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selectin in an in vivo model of acute inflammation. Circulation, 103(1), 108–112. https://doi.org/10.1161/01.cir.103.1.108
Cohen, S., Mermelstein, R., Kamarck, T. y Hoberman, H. M. (1985). Measuring the functional components of social support Social support. en I. G. Sarason, B. R. Sarason (Eds.), Theory, research and applications (pp. 73-94). Springer.
Cole, P. M., Michel, M. K., y Teti, L. O. (1994). The development of emotion regulation and dysregulation: a clinical perspective. Monographs of the Society for Research in Child Development, 59(2-3), 73–100. https://doi.org/10.1111/j.1540-5834.1994.tb01278.x
Cólica, P. R. (2021). Conductas emocionales y estrés. Pinelatinoamericana, 1(1), 12–17. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/36036
Cullen, P., Schulte, H., y Assmann, G. (1997). The Münster Heart Study (PROCAM): total mortality in middle-aged men is increased at low total and LDL cholesterol concentrations in smokers but not in nonsmokers. Circulation, 96(7), 2128–2136. https://doi.org/10.1161/01.cir.96.7.2128
de Kloet, E. R., Joëls, M., y Holsboer, F. (2005). Stress and the brain: from adaptation to disease. Nature reviews. Neuroscience, 6(6), 463–475. https://doi.org/10.1038/nrn1683
Degroote, C., von Känel, R., Thomas, L., Zuccarella-Hackl, C., Pruessner, J. C., Wiest, R., y Wirtz, P. H. (2021). Acute Stress-Induced Blood Lipid Reactivity in Hypertensive and Normotensive Men and Prospective Associations with Future Cardiovascular Risk. Journal of clinical medicine, 10(15), 3400. https://doi.org/10.3390/jcm10153400
Dich, N., Doan, S. N., Kivimäki, M., Kumari, M., y Rod, N. H. (2014). A non-linear association between self-reported negative emotional response to stress and subsequent allostatic load: prospective results from the Whitehall II cohort study. Psychoneuroendocrinology, 49, 54–61. https://doi.org/10.1016/j.psyneuen.2014.07.001
Dodani, S., Kaur, R., Reddy, S., Reed, G. L., Navab, M., y George, V. (2008). Can dysfunctional HDL explain high coronary artery disease risk in South Asians?. International journal of cardiology, 129(1), 125–132. https://doi.org/10.1016/j.ijcard.2007.12.019
Duivis, H. E., Vogelzangs, N., Kupper, N., de Jonge, P., y Penninx, B. W. (2013). Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation: findings from the Netherlands Study of Depression and Anxiety (NESDA). Psychoneuroendocrinology, 38(9), 1573–1585. https://doi.org/10.1016/j.psyneuen.2013.01.002
Emerging Risk Factors Collaboration, Di Angelantonio, E., Sarwar, N., Perry, P., Kaptoge, S., Ray, K. K., Thompson, A., Wood, A. M., Lewington, S., Sattar, N., Packard, C. J., Collins, R., Thompson, S. G., y Danesh, J. (2009). Major lipids, apolipoproteins, and risk of vascular disease. JAMA, 302(18), 1993–2000. https://doi.org/10.1001/jama.2009.1619
Eng, P. M., Fitzmaurice, G., Kubzansky, L. D., Rimm, E. B., y Kawachi, I. (2003). Anger expression and risk of stroke and coronary heart disease among male health professionals. Psychosomatic medicine, 65(1), 100–110. https://doi.org/10.1097/01.psy.0000040949.22044.c6
Faur, A. (2016). Correlation between depression and stress test at patients with ischemic heart. Medicina Sportiva: Journal of Romanian Sports Medicine Society, 12(1), 2715.
Fava, G. A., Guidi, J., Semprini, F., Tomba, E., y Sonino, N. (2010). Clinical assessment of allostatic load and clinimetric criteria. Psychotherapy and psychosomatics, 79(5), 280–284. https://doi.org/10.1159/000318294
Folkman S. (2008). The case for positive emotions in the stress process. Anxiety, stress, and coping, 21(1), 3–14. https://doi.org/10.1080/10615800701740457
Ginzburg, K., Solomon, Z., Koifman, B., Keren, G., Roth, A., Kriwisky, M., Kutz, I., David, D., y Bleich, A. (2003). Trajectories of posttraumatic stress disorder following myocardial infarction: a prospective study. The Journal of clinical psychiatry, 64(10), 1217–1223. https://doi.org/10.4088/jcp.v64n1012
Gomez Rosso, L., Lhomme, M., Meroño, T., Dellepiane, A., Sorroche, P., Hedjazi, L., Zakiev, E., Sukhorukov, V., Orekhov, A., Gasparri, J., Chapman, M. J., Brites, F., y Kontush, A. (2017). Poor glycemic control in type 2 diabetes enhances functional and compositional alterations of small, dense HDL3c. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1862(2), 188–195. https://doi.org/10.1016/j.bbalip.2016.10.014
Gross, J. J., y Levenson, R. W. (1997). Hiding feelings: the acute effects of inhibiting negative and positive emotion. Journal of abnormal psychology, 106(1), 95–103. https://doi.org/10.1037//0021-843x.106.1.95
Han, C. Y., Tang, C., Guevara, M. E., Wei, H., Wietecha, T., Shao, B., Subramanian, S., Omer, M., Wang, S., O'Brien, K. D., Marcovina, S. M., Wight, T. N., Vaisar, T., de Beer, M. C., de Beer, F. C., Osborne, W. R., Elkon, K. B., y Chait, A. (2016). Serum amyloid A impairs the antiinflammatory properties of HDL. The Journal of clinical investigation, 126(1), 266–281. https://doi.org/10.1172/JCI83475
Harrison, N. A., Cooper, E., Voon, V., Miles, K., y Critchley, H. D. (2013). Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression?. Brain, behavior, and immunity, 31, 189–196. https://doi.org/10.1016/j.bbi.2013.02.001
Haynes, S. G., Feinleib, M., y Kannel, W. B. (1980). The relationship of psychosocial factors to coronary heart disease in the Framingham Study. III. Eight-year incidence of coronary heart disease. American journal of epidemiology, 111(1), 37–58. https://doi.org/10.1093/oxfordjournals.aje.a112873
Henao-Pérez, M. (2021). Estrés y depresión como factores pronósticos en pacientes con enfermedad coronaria. [Tesis de doctorado, Universidad Pablo de Olavide de Sevilla. Departamento de Fisiología, Anatomía y Biología Celular] Repositorio Institucional Olavide http://hdl.handle.net/10433/12104
Juster, R. P., McEwen, B. S., y Lupien, S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition. Neuroscience and biobehavioral reviews, 35(1), 2–16. https://doi.org/10.1016/j.neubiorev.2009.10.002
Khera, A. V., Cuchel, M., de la Llera-Moya, M., Rodrigues, A., Burke, M. F., Jafri, K., French, B. C., Phillips, J. A., Mucksavage, M. L., Wilensky, R. L., Mohler, E. R., Rothblat, G. H., y Rader, D. J. (2011). Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. The New England journal of medicine, 364(2), 127–135. https://doi.org/10.1056/NEJMoa1001689
Kiank, C., Zeden, J. P., Drude, S., Domanska, G., Fusch, G., Otten, W., y Schuett, C. (2010). Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans. PloS one, 5(7), e11825. https://doi.org/10.1371/journal.pone.0011825
Kivimäki, M., Lawlor, D. A., Singh-Manoux, A., Batty, G. D., Ferrie, J. E., Shipley, M. J., Nabi, H., Sabia, S., Marmot, M. G., y Jokela, M. (2009). Common mental disorder and obesity: insight from four repeat measures over 19 years: prospective Whitehall II cohort study. BMJ (Clinical research ed.), 339, b3765. https://doi.org/10.1136/bmj.b3765
Lanas, F., Avezum, A., Bautista, L. E., Diaz, R., Luna, M., Islam, S., Yusuf, S., y INTERHEART Investigators in Latin America (2007). Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study. Circulation, 115(9), 1067–1074. https://doi.org/10.1161/CIRCULATIONAHA.106.633552
Lichtman, J. H., Froelicher, E. S., Blumenthal, J. A., Carney, R. M., Doering, L. V., Frasure-Smith, N., Freedland, K. E., Jaffe, A. S., Leifheit-Limson, E. C., Sheps, D. S., Vaccarino, V., Wulsin, L., y American Heart Association Statistics Committee of the Council on Epidemiology and Prevention and the Council on Cardiovascular and Stroke Nursing (2014). Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations: a scientific statement from the American Heart Association. Circulation, 129(12), 1350–1369. https://doi.org/10.1161/CIR.0000000000000019
Martínez J. C. (2016). Biomedica : revista del Instituto Nacional de Salud, 36(4), 535–546. https://doi.org/10.7705/biomedica.v36i4.3069
Mineo, C., Deguchi, H., Griffin, J. H., y Shaul, P. W. (2006). Endothelial and antithrombotic actions of HDL. Circulation research, 98(11), 1352–1364. https://doi.org/10.1161/01.RES.0000225982.01988.93
Namiri-Kalantari, R., Gao, F., Chattopadhyay, A., Wheeler, A. A., Navab, K. D., Farias-Eisner, R., y Reddy, S. T. (2015). The dual nature of HDL: Anti-Inflammatory and pro-Inflammatory. BioFactors (Oxford, England), 41(3), 153–159. https://doi.org/10.1002/biof.1205
Nekouei, Z. K., Yousefy, A., Doost, H. T., Manshaee, G., y Sadeghei, M. (2014). Structural Model of psychological risk and protective factors affecting on quality of life in patients with coronary heart disease: A psychocardiology model. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 19(2), 90–98.
Oh, J., y Kim, T. S. (2017). Serum lipid levels in depression and suicidality: The Korea National Health and Nutrition Examination Survey (KNHANES) 2014. Journal of affective disorders, 213, 51–58. https://doi.org/10.1016/j.jad.2017.02.002
Papageorgiou, N., Zacharia, E., Androulakis, E., Briasoulis, A., Charakida, M., y Tousoulis, D. (2016). HDL as a prognostic biomarker for coronary atherosclerosis: the role of inflammation. Expert opinion on therapeutic targets, 20(8), 907–921. https://doi.org/10.1517/14728222.2016.1152264
Pereira, V. H., Cerqueira, J. J., Palha, J. A., y Sousa, N. (2013). Stressed brain, diseased heart: a review on the pathophysiologic mechanisms of neurocardiology. International journal of cardiology, 166(1), 30–37. https://doi.org/10.1016/j.ijcard.2012.03.165
Rader D. J. (2006). Molecular regulation of HDL metabolism and function: implications for novel therapies. The Journal of clinical investigation, 116(12), 3090–3100. https://doi.org/10.1172/JCI30163
Richardson, S., Shaffer, J. A., Falzon, L., Krupka, D., Davidson, K. W., y Edmondson, D. (2012). Meta-analysis of perceived stress and its association with incident coronary heart disease. The American journal of cardiology, 110(12), 1711–1716. https://doi.org/10.1016/j.amjcard.2012.08.004
Riwanto, M., Rohrer, L., Roschitzki, B., Besler, C., Mocharla, P., Mueller, M., Perisa, D., Heinrich, K., Altwegg, L., von Eckardstein, A., Lüscher, T. F., y Landmesser, U. (2013). Altered activation of endothelial anti- and proapoptotic pathways by high-density lipoprotein from patients with coronary artery disease: role of high-density lipoprotein-proteome remodeling. Circulation, 127(8), 891–904. https://doi.org/10.1161/CIRCULATIONAHA.112.108753
Steptoe, A., y Brydon, L. (2005). Associations between acute lipid stress responses and fasting lipid levels 3 years later. Health psychology: official journal of the Division of Health Psychology, American Psychological Association, 24(6), 601–607. https://doi.org/10.1037/0278-6133.24.6.601
Sutcigil, L., Oktenli, C., Musabak, U., Bozkurt, A., Cansever, A., Uzun, O., Sanisoglu, S. Y., Yesilova, Z., Ozmenler, N., Ozsahin, A., y Sengul, A. (2007). Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy. Clinical y developmental immunology, 2007, 76396. https://doi.org/10.1155/2007/76396
Toker, S., Shirom, A., Shapira, I., Berliner, S., y Melamed, S. (2005). The association between burnout, depression, anxiety, and inflammation biomarkers: C-reactive protein and fibrinogen in men and women. Journal of occupational health psychology, 10(4), 344–362. https://doi.org/10.1037/1076-8998.10.4.344
Vaccarino, V., Johnson, B. D., Sheps, D. S., Reis, S. E., Kelsey, S. F., Bittner, V., Rutledge, T., Shaw, L. J., Sopko, G., Bairey Merz, C. N., y National Heart, Lung, and Blood Institute (2007). Depression, inflammation, and incident cardiovascular disease in women with suspected coronary ischemia: the National Heart, Lung, and Blood Institute-sponsored WISE study. Journal of the American College of Cardiology, 50(21), 2044–2050. https://doi.org/10.1016/j.jacc.2007.07.069
Wirtz, P. H., y von Känel, R. (2017). Psychological Stress, Inflammation, and Coronary Heart Disease. Current cardiology reports, 19(11), 111. https://doi.org/10.1007/s11886-017-0919-x
Wolf, J. M., Rohleder, N., Bierhaus, A., Nawroth, P. P., y Kirschbaum, C. (2009). Determinants of the NF-kappaB response to acute psychosocial stress in humans. Brain, behavior, and immunity, 23(6), 742–749. https://doi.org/10.1016/j.bbi.2008.09.009
World Health Organization. (2014). Global status report on noncommunicable diseases 2014. Geneva: WHO. https://apps.who.int/iris/handle/10665/148114
Yusuf, S., Hawken, S., Ounpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., Lisheng, L., y INTERHEART Study Investigators (2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet (London, England), 364(9438), 937–952. https://doi.org/10.1016/S0140-6736(04)17018-9
Zautra, A. J. (2006). Emotions, Stress, and Health: Oxford University Press.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright (c) 2023 Pinelatinoamericana