Molecular epidemiology pattern of hepatitis C virus infection in central region of Argentina

Authors

  • Viviana E. Ré
  • Adrián A. Farías
  • María P. Díaz
  • María B. Pisano
  • Silvia Mengarelli
  • Luis Kremer
  • Osvaldo Elbarcha
  • Marta Contiagiani

DOI:

https://doi.org/10.31052/1853.1180.v13.n2.7122

Keywords:

Virus de la hepatitis C (HCV), genotipos, epidemiología molecular, coinfección HCV/HIV, Argentina

Abstract

The presence of HCV RNA and genotype distribution among 310 samples from Central region of Argentina was detected by molecular techniques (RT-nested PCR and RFLP). HCV/HIV coinfection was 11,8% and genotype 1 was more prevalent (73%) in this group. Among HCV monoinfected individuals the prevalence of genotypes 1 and 2 were 49.4% and 43,9%, respectively.

Logistic regression analysis showed that age and intravenous drug use (IVDU) are independent determinants of genotype distribution. Genotype 2 had higher prevalence in people older than 50 years, but not association with routes of transmission could be found. The prevalence of genotype 1 was due to the use IVDU among young adults. The increasing prevalence of genotype 1, homogeneously distributed in all ages has important implications in therapeutic decisions, considering its low response to antiviral therapy.

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Author Biographies

  • Viviana E. Ré

    Instituto de Virología “Dr. José M. Vanella”, Fac. de Cs. Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gómez s/n, 5016 Córdoba, Argentina.

    Cátedra de Virología. Fac. de Cs. Químicas, Universidad Católica de Córdoba

  • Adrián A. Farías
    Instituto de Virología “Dr. José M. Vanella”, Fac. de Cs. Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gómez s/n, 5016 Córdoba, Argentina.
  • María P. Díaz
    Instituto de Virología “Dr. José M. Vanella”, Fac. de Cs. Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gómez s/n, 5016 Córdoba, Argentina.
  • María B. Pisano
    Instituto de Virología “Dr. José M. Vanella”, Fac. de Cs. Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gómez s/n, 5016 Córdoba, Argentina.
  • Silvia Mengarelli
    Hospital San Roque - Córdoba, Argentina.
  • Luis Kremer
    Hospital Nacional de Clínicas, Córdoba, Argentina.
  • Osvaldo Elbarcha
    Cátedra de Virología. Fac. de Cs. Químicas, Universidad Católica de Córdoba.
  • Marta Contiagiani
    Instituto de Virología “Dr. José M. Vanella”, Fac. de Cs. Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gómez s/n, 5016 Córdoba, Argentina.

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Issue

Vol. 13 No. 2 (2009)

Section

Scientific Articles

License

Copyright (c) 2014 Escuela de Salud Pública y Ambiente. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba

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How to Cite

1.
Molecular epidemiology pattern of hepatitis C virus infection in central region of Argentina. Rev. Salud Pública (Córdoba) [Internet]. 2014 Apr. 7 [cited 2024 Oct. 4];13(2):15-21. Available from: https://revistas.unc.edu.ar/index.php/RSD/article/view/7122