PATTERNS OF ORBITOFACIAL AND ORBITAL GROWTH AT PRENATAL STAGE DERIVED FROM FETAL AUTOPSY STUDIES. Patrones de crecimiento órbito-facial y orbital en la etapa prenatal derivados de los estudios de autopsias fetales
DOI:
https://doi.org/10.31051/1852.8023.v3.n1.13913Keywords:
fetal autopsy, fetal biometry, fetal orbit, facial growth, morphometry, autopsies fetales, biometría fetal, órbita fetal, crecimient facial, morfometría,Abstract
Objetivo: Las mediciones orbitofaciales y orbitales del feto pueden ser útiles para el diagnóstico precoz prenatal de malformaciones craneofaciales. La mayoría de los estudios anteriores se basan en la ecografía y sólo hay unos cuantos estudios basados en autopsias fetales. El Análisis detallado de los distintos parámetros puede proporcionar una base de datos útil para una rápida referencia. Métodos: En cincuenta fetos normales de edades gestacionales diferentes, se midieron los siguientes parámetros: las distancias cantales externa e interna, la longitud de la hendidura palpebral, la longitud oropalpebral, la profundidad y la anchura de la órbita y la distancia interorbital. Resultados: El análisis estadístico reveló una correlación positiva significativa de todos estos parámetros con la edad gestacional y con el diámetro biparietal. Los patrones de crecimiento de los pará-metros orbitales y orbitofacial también demostraron una correlación significativa entre sí. Conclusión: Nuestros resultados muestran que el aumento de las partes laterales de la cara y de la longitud facial vertical se produce a un ritmo más rápido en comparación con la parte media de la cara. Las desviaciones de los datos normativos generados para los parámetros orbitales y orbitofacial ayudarán en la detección precoz de síndromes genéticos específicos.
Objective: Fetal orbitofacial and orbital measurements may be helpful in early prenatal diagnosis of craniofacial malformation. Most of the earlier studies are ultrasound based and there are only a few studies based on fetal autopsies. Comprehensive analysis of various parameters can provide useful database for easy reference. Methods: In fifty normal fetuses of different gestational ages, the following parameters were measured: outer and inner canthal distances, palpebral fissure length, oropalpebral length, depth and width of orbit and inter orbital distance. Results: Statistical analysis revealed significant positive correlation of all these parameters with gestational age and biparietal diameter. The growth patterns of the orbitofacial and orbital measurements also demonstrated significant correlation between these parameters. Conclusion: Our results demonstrate that the lateral parts of the face and the vertical facial length grow at a faster rate than the median part of the face. Deviations from the normative data generated for the orbitofacial and orbital parameters will help in early detection of specific genetic syndromes.
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