Pleomorphic adenoma of the lacrimal gland: atypical location of a salivary tumor

Authors

  • María Elena Samar

Keywords:

lacrimal gland, pleomorphic adenoma, histopathology, immunohistochemistry

Abstract

Introduction: In daily ophthalmological practice, lacrimal gland tumors are rare. They represent 5 to 7.5% of all intraorbital tumors. The most common epithelial tumor of this gland is the pleomorphic adenoma, with a percentage of 25 to 50% of its tumor lesions.
Objective: In this communication we presented a case of lacrimal gland pleomorphic adenoma and study the expression of Ki67 and the location and expression of MUC-1 and its correlation with tumor prognosis. We also carried out a retrospective descriptive study of the literature on the subject published between 1951 and 2020, using the MEDLINE database. Material and methods: The surgical piece examined, was processed according to the paraffin embedding technique, was performed with a histopathological diagnosis of pleomorphic lacrimal gland adenoma. Histological sections were stained with Hematoxylin / Eosin. Immunostaining with Ki67 and MUC-1 was performed with the DAKO LSAB + kit. Results: The diagnosis of hypercellular pleomorphic adenoma with areas of the remaining lacrimal gland was made. Ki67 labeling was low (≤15%). MUC-1 expression was intense, situated to the apical cell membrane of approximately 10% epitheliocytes from pseudoductal and cystic structures.Conclusions: Through histopathological evaluation, the correlation of Ki67 expression and the location and expression of MUC1, we verified that it is a non-recurrent pleomorphic adenoma without malignant transformation.

Downloads

Download data is not yet available.

References

Obata H. Anatomy and histopathology of the human lacrimal gland. Cornea 2006; 25: S82-S89.

Yao Y, Zhang Y. The lacrimal gland: development, wound repair and regeneration. Biotechnol Lett 2017; DOI 10.1007/s10529-017-2326-1.

Welsch U, Deller T. Sobotta. Histología. 3º ed. México: Ed Médica Panamericana, 2013: 513-514.

Ayala PE, Dermith AM, Antúnez HS, Murillo TP. Adenoma pleomorfo de glándula lagrimal: reporte de un caso pediátrico. Rev Esp Patol 2020; 53: 55-60

Porto M, Pane M, García M, Mussi D, Aquino Caballero O. Adenoma pleomorfo de glándula lagrimal: a propósito de un caso. Cir Parag 2019; 44: 27-28.

Organización Mundial de la Salud. WHO/IARC. Classification of Head and Neck Tumours. 4th ed. WHO. Lyon: Edited by El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, 2017.

Samar ME, Avila RE. Tumores Epiteliales de Glándulas Salivales. Saarbrücken. Alemania: Editorial Académica Española, 2013.

Ellis GL, Auclair PL. Tumors of salivary glands. Washington, DC: American Registry of Pathology Armed Forces Institute of Pathology, 2008.

Li LT, Jiang G, Chen Q, Zheng, JN. Ki67 is a promising molecular target in the diagnosis of cancer. Mol. Med. Reports 2015; 11: 1566-1572.

Syrkina, MS, Vassetzky YS, Rubtsov MA. MUC-1 story: great expectations, disappointments and the renaissance. Current Med. Chem 2017; 24: 1-10.

Samar ME, Avila RE, Esteban Ruiz F. Técnicas histológicas. Fundamentos y aplicaciones. Córdoba: Editorial SeisC, 2004.

Langner C, Ratschek M, Rehak P, Schips L, Zigeuner R. Expression of MUC-1 (EMA) and E-cadherin in renal cell carcinoma: a systematic immunohistochemical analysis of 188 cases. Modern Pathol 2004; 7: 180-188.

PUBMED. https://www.ncbi.nlm.nih.gov/pubmed. Consulta: 18/02/2020. (Última consulta: 10 de abril de 2020).

Tailor TD, Gupta D, Dalley RW, Keene D, Anzai Y. Orbital neoplasms in adults: clinical, radiologic and pathologic review. Radiographics 2013; 33: 1739-1758.

Binatli O, Yaman O, Ozdemir N, Gokcol Erdogan I. Pleomorphic adenoma of lacrimal gland. J Surg Case Rep 2013; doi:10.1093/jscr/rjt089

Schittkowski MP y Storch MW. Diseases of the lacrimal gland. Klin Monbl Augenheilkd 2020; doi :10.1055/a-1068-76992020

Bhuyan J y Varrosang Varte D. Pleomorphic adenoma of lacrimal gland with intraconal extension- A rare case report. Indian J Appl Res 2019; 9: 25-26.

Iyeyasu JN, Reis F, Altemani AM, Monteiro de Carvalho K.An unusual presentation of lacrimal gland pleomorphic adenoma. Rev Bras Oftalmol 2013; 72: 338-340.

Currie ZI y Rose GE. Long-term risk of recurrence after intact excision of pleomorphic adenomas of the lacrimal gland. Arch Ophthalmol 2007; 125: 1643-1646.

Borges Soares A, Dias Demasi AP, Altemani A, Calvacanti de Araujo V. Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma. Histopathology 2011; 58: 377-382.

Henriksson G, Westrin KM, Carlsoo B, Silfversward C. Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features and pseudopodia. Cancer 1998; 82: 617-620.

Ponce-Bravo S, Ledesma-Montes C, Morales- Sánchez I. MUC-1 mucin in normal human salivary glands detected by HMFG-1 and HMFG-2 monoclonal antibodies. APMIS 2008; 116: 93-98.

Lau SK, Weiss LM, Chu PG. Differential expression of MUC1, MUC2 and MUC5AC in carcinomas of various sites. An immunohistochemical study. Am J Clin Pathol 2004; 122: 61-69.

Behera SK, Praharaj AB, Dehury B. Exploring the role and diversity of mucins in heath and disease with special insight into non-communicable diseases. Glyconj J 2015; DOI 10.1007/s10719-015—9606-6.

Li Y, Zhou C, Li J, Llu J, Lin L, Li L, Cao D, Li Q, Wang Z. Single domain based bispecific antibody, Muc1-B1, and its humanized form, Muc1-B2, induce potent cancer cell killing in muc1 positive tumor cells. PLoS ONE 2018; 13: e0191024. http://doi.org/10.1371/journal.pone.0191024.

Paulsen F, Langer G, Hoffman W, Berry M. Human lacrimal gland mucins. Cell Tissue Res 2004; 316: 167-177. 2004

Hamada T, Matsukita S, Goto M, Kitajima S, Batra SK, Irimura T, Sueyoshi K, Sugihara K, Yonezawa S. Mucin expression in pleomorphic adenoma of salivary gland: a potential role for MUC1 as a marker to predict recurrence. J Clin Pathol 2004; 57: 813-821.

Gao P, Zhou GY, Song XR, Hou JX, Zhang CJ, Ma C. The relationship of abnormal expression of cell glycoprotein with recurrence of pleomorphic adenoma in salivary gland. Hua Xi Kou Qiang Yi Xue Za Zhi 2005; 23: 164-166.

Zhang P. Tang LJ, Gao HH, Zhang WX, Lin JX, Yang HS. Immunohistochemical features of carcinoma ex pleomorphic adenoma and pleomorphic adenoma in the lacrimal gland. Int J Ophthalmol 2019; 12: 1238-1242.

Ma S, An F, Li H, Lin YY, Wang J. Expression of Mucin 1 in salivary gland tumors and its correlation with clinicopathological factors. J Biol Regul Homeost Agents 2019; 33: 563-569

Downloads

Published

2020-12-08

Issue

Vol. 30 No. 3 (2020): Rev Fac Odont vol 30 (3) 2020

Section

RESEARCH

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes:

  1. Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons que permite a terceros:
    • La licenciante no puede revocar estas libertades en tanto usted siga los términos de la licencia
  2. Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
  3. Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) después del su publicación en la revista, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).