español

Authors

  • Cecilia Gosso UNC facultad de odontología departamento de biología bucal

Keywords:

prevalence-dental agenesis

Abstract

OBJECTIVE.To know, through a clinical study, the prevalence of dental agenesis in patients under orthodontic treatment of a population of the City of Córdoba. METHODS. Retrospective study of clinical histories and orthopantomographs of patients (n = 762), aged between 5 and 24 years, from the City of Córdoba between 2007 and 2017. The identification of agenesis was carried out through the analysis of orthopantomographs. Medical and dental records were used as reference materials to avoid an incorrect diagnosis of dental agenesis. The absolute and relative frequency of agenesis were calculated for each tooth of each patient, in each of the years studied. The frequency of this pathology was compared between the group without the presence of agenesis and with agenesis and between the years using the Chi Square test or Fisher's exact test. A p-value <0.05 was set for statistical significance. The data was analyzed with the Infostat 2016 version program. RESULTS. The number of subjects attended (n = 762), varied between 71 to 101 per year. No significant differences were found between men and women regarding agenesis. The percentage of agenesis varied significantly (p = 0.0001) from 2007 to 2017, both in men and women. The prevalence of agenesis was 22.7%. All observed agenesis were permanent elements. The upper and lower third molar are the elements that presented the highest frequency of agenesis. CONCLUSIONS. Human dentition is complex and varied and is related to the diet, environment and social demands of the species. More than 10% of humans do not develop any permanent element; This has a genetic component and could reflect the evolution in relation to food softening behaviors.

Downloads

Download data is not yet available.

References

1. Ceballos, O. D. M.; Espinal, G. E. & Jones, M. Anomalías en el desarrollo y formación dental: odontodisplasia. Int. J. Odontostomat. 2015; 9(1):129-136.
2. Kolenc-Fusé FJ. Agenesias dentarias: en busca de las alteraciones genéticas responsables de la falta de desarrollo. Med Oral Patol Oral Cir Bucal. 2004; 9:385-95.
3. Vastardis H. The genetics of human tooth agenesis: new discoveries for understanding dental anomalies. Am J Orthod Dentofacial Orthop. 2000; 117(6):650-6.
4. Feng HL, Zhang XX, Wu H. Research advances in tooth agenesis. Beijing Da Xue Xue Bao. 2007; 39(1):13-7.
5. Peres RC, Scarel-Caminaga RM, do Espirito Santo AR, Line SR. Association between PAX-9 promoter polymorphisms and hypodontia in humans. Arch Oral Biol 2005;50(10):86171.
6. Echeverri Escobar J, Restrepo Perdomo LA, Vásquez Palacio G, Pineda Trujillo N, Isaza Guzmán DM, Manco Guzmán HA, Marín Botero ML.Toothagenesis: Epidemiological, clinical and geneticanalysis in patientsfrom Antioquia.AvancesOdontoestomatología. 2013; 29(3): 119-130.
7. Alessandro Salvi, Edoardo Giacopuzzi, Elena Bardellini, Francesca Amadori, Lía Ferrari, Giuseppina De Petro, Giuseppe Borsani , Alessandra Majorana . Mutation analysis by direct and whole exome sequencing in familial and sporadic tooth agenesis INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2016; 38: 1338-1348, 20161344.
8. Klein ML, Nieminen P, Lammi L, Niebuhr E, Kreiborg S. Novel mutation of the initiation codon of PAX9 causes oligodontia. J Dent Res. 2005;84(1):43-7.
9. Nieminen P, Arte S, Tanner D, Paulin L, Alaluusua S, Thesleff I et al. Identification of a nonsense mutation in the PAX9 gene in molar oligodontia. Eur J Hum Genet. 2001; 9(10):743-6.
10. Tallón-Walton V, Manzanares-Céspedes MC, Carvalho-Lobato P, Valdivia-Gandur I, Arte S, Nieminen P. Exclusion of PAX9 and MSX1 muta. Exclusion of PAX9 and MSX1 mutation in six families affected by tooth agenesis. A genetic study and literature review. Med Oral Patol Oral Cir Bucal. 2014;19 (3): e248-54.
11. Thomas BL and Sharpe PT. Patterning of the murine dentition by homeobox genes. Eur J Oral Sci. 1998; 106:48-54.
12. Chhabra N, Goswami M, Chhabra A. Genetic basis of dental agenesis - molecular genetics patterning clinical dentistry. Med Oral Patol Oral Cir Bucal.2014; 19 (2):e112-9).
13. Mostowska, A.; Biedziak, B. & Trzeciak, W. A novel mutation in PAX9 causes familial form of molar oligodontia. Eur. J. Hum. Genet. 2006; 14(2):173-9.
14. Miletich, I. & Sharpe, P. T. Normal and abnormal dental development. Hum. Mol. Genet., 2003;12(Spec. No. 1): R6973.
15. Sanpei S, Ishida R, Sanpei S, Endo S, Tanaka S, Endo T, Sekimoto T.Patterns of bilateral agenesis of maxillarythirdmolars and agenesis of otherteeth.Odontology. 2016;104(1):98-104.
16. Barka, G.; Tretiakov, G.; Theodosiou, T. & Ioannidou-Marathiotou, I. Presence of third molars in orthodontic patients from northern Greece. Int. J.Gen. Med. 2012; 5:441-7.
17. Kazanci, F.; Celikoglu, M.; Miloglu, O. & Oktay, H. Third-molar agenesis among patients from the east Anatolian region of Turkey. J. Contemp. Dent. Pract. 2010; 11(4): e033-40.
18. Mok, Y. Y. & Ho, K. K. Congenitally absent third molars in 12 to 16 year old Singaporean Chinese patients: A retrospective radiographic study. Ann. Acad. Med. Singapore, 1996; 25(6):828- 30.
19.Silva Meza, R. Radiographic assessment of congenitally missing teeth in orthodontic patients. Int. J. Paediatr. Dent. 2003; 13(2):112- 6.
20. Aasheim B and Ögaard B. Hypodontia in 9 – year – old Norwegians to need of orthodontic treatment. Scand J Dent Res. 1993; 101:257-60.
21.Tallon-Walton V, Nieminen P, Arte S, Carvalho-Lobato P, UstrellTorrent JM, Manzanares-Céspedes MC. An epidemiological study of dental agenesis in a primary health area in Spain: estimated prevalence and associated factors. Med Oral Patol Oral Cir Bucal. 2010;15: e569-74.
22.Vastardis H. The genetics of human tooth agenesis: new discoveries for understanding dental anomalies. Am J Orthod Dentofacial Orthop 2000 ;117(6):650-6.
23. Frazier-Bowers SA, Pham KY, Le EV, Cavender AC, Kapadia H, King TM et al. A unique form of hypodontia seen in Vietnamese patients: clinical and molecular analysis. J Med Genet 2003;40 (6): e79.
24. Arte S, Nieminen P, Apajalahti S, Haavikko K, Thesleff I, Pirinen S. Characteristics of incisorpremolar hypodontia in families. J Dent Res. 2001 ;80(5):1445-50.
25. Xuan K, Jin F, Liu YL, Yuan LT, Wen LY, Yang FS et al. Identification of a novel missense mutation of MSX1 gene in Chinese family, with autosoma ldominant oligodontia. Arch Oral Biol 2008; 53:773-9.
26. Nieminen P. Molecular genetics of tooth agenesis. Finland: University of Helsinki; 2007.
27.Herrera-Atoche, J. R.; Colomé-Ruiz, G. E. & Escoffié-Ramírez, M. Agenesia de terceros molares, prevalencia, distribución y asociación con otras anomalías dentales. Int. J. Morphol., 2013; 31(4):1371-1375.
28 García-Hernández Fernando, Araneda Rodriguez Claudia Patricia. Agenesia del Tercer Molar en Pacientes Atendidos en la Clínica Odontológica de la Universidad de Antofagasta, Chile. Int. J. Morphol. 2009; 27(2): 393-402.
Revista Facultad Odontología-UNC vol 30 num 1- año 2020

Downloads

Published

2020-03-26

Issue

Vol. 30 No. 1 (2020): Revista de la Facultad de Odontología-UNC

Section

RESEARCH

License

Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes:

  1. Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons que permite a terceros:
    • La licenciante no puede revocar estas libertades en tanto usted siga los términos de la licencia
  2. Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
  3. Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) después del su publicación en la revista, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).