Understanding what Pan Genome is

Authors

  • Mabel Brunotto

Keywords:

pangenome

Abstract

The term Pangenome began to be used in 2005, and its meaning is complete from the Greek pan. It was first studied in bacteria and, in this context, the term refers to a central genome that contains the genes present in all strains, and a dispensable genome that is made up of genes absent in one or more strains and genes that are exclusive. of each strain of the same species, thereby capturing the entire gene content of a species

References

1. Wang T, Antonacci-Fulton L, Howe K, et al. The Human Pangenome Project: a global resource to map genomic diversity. Nature. 2022;604(7906):437-446. doi:10.1038/s41586-022-04601-8 2. Tettelin H, Masignani V, Cieslewicz MJ, et al. Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome" Proc Natl Acad Sci U S A. 2005;102(39):13950-13955. doi:10.1073/pnas.0506758102 3. Liao WW, Asri M, Ebler J, et al. A draft human pangenome reference. Nature. 2023;617(7960):312-324. doi:10.1038/s41586-023-05896-x 4. Hammond JA, Gordon EA, Socarras KM, Chang Mell J, Ehrlich GD. Beyond the pan-genome: current perspectives on the functional and practical outcomes of the distributed genome hypothesis. Biochem Soc Trans.2020;48(6):2437-2455.

Published

2024-03-07