Mast cell population in salivary glands of rats which underwent castration and DMBA application

Authors

  • M Fonseca
  • M. E. Ferraris
  • M L De David Rins
  • H Gendelman

Keywords:

Mastocytosis, Salivary Glands, Rats, 9, 10-Dimethyl-1, 2-benzanthracene

Abstract

castration and simultaneous application of DMBA. Wistar young males were used, in groups of five animales each. They were

sacriíiced lZ, Z3 and Z8 days after the experlment was started. The glands werediss~cted and fixed in 10 % formol at Ph. 7 in arder to be . studiedmorphohistochemically and histometrically. The number of mast cells increased in the sublingual gland (SLG) at all the time perlods studied, outnumbering considerably the cell population in the sub maxillary gland (SMG) lZ days after the animals had been castrated. When comparing uncastrated · animals with castrated ones, it is noticed that the most importantdifíerences in the mast cell population appear in the SLG. With application of DMBA and simultaneous castration, it is observed that the sublingual gland (which normally has very little receptivity to DMBA in un castrated animals) experiences an atypical tissue response accompanied by anincrease in its mast cell population

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Published

2018-09-19

Issue

Section

ARTÍCULOS