Productos naturales en la búsqueda de compuestos antimicrobianos :
estrategias actuales
Keywords:
Productos naturales, actividad antimicrobiana, resistencia a fármacos, semisíntesis, vehiculizaciónAbstract
Antimicrobial resistance is one of the most serious health problems worldwide, as many pathogens are rapidly developing resistance to the existing treatments. In the current scenario, there is no effective therapeutic agent with the potential to reverse antimicrobial resistance, so many leading laboratories (at industrial and academic level) are working intensively to discover new therapeutic agents. In this sense, natural compounds of plant origin are relatively less studied in the context of antimicrobial drug development.
Natural products have been of great interest in the drug discovery process due to their structural diversity and complexity, chemical novelty, and bioactivity. Thus, to date, the isolation of natural compounds from various organisms has been described, including bacteria, fungi, invertebrates, marine organism and plants. All of these have made significant contributions to the development of drugs for various human diseases. To cite some examples, doxorubicin, bleomycins, penicillins, epothilones, paclitaxel, camptothecin, podophyllotoxins and vinca alkaloids are today some of the best-known active ingredients derived from bacteria, fungi or plants. For all above, in this perspective article, we will address the topic from the different approaches that are currently used to explore the antimicrobial therapeutic potential of metabolites of plant origin or their derivatives.
Finally, after analyzing the sections presented, we arrive to the conclusion of the urgent need for exhaustive research into the antimicrobial potential of plant metabolites. Indeed, these privileged biologically relevant structures can constitute new chemical entities with improved antimicrobial efficacy through their derivatization or vehiculization. Another important point to highlight is the need to examine the role of these compounds together with antibiotics currently used in clinical practice in order
to explore possible synergistic effects.
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